A. Michael Lincoff et al., „Semaglutide and cardiovascular outcomes in obesity without diabetes,” New England Journal of Medicine 389, no. 24 (December 2023): 2221–2232.
A. Tomar et al., „Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs,” Nature 630, no. 8017 (June 2024): 720–727.
Aaron Cypess, „Reassessing human adipose tissue,” New England Journal of Medicine 386, no. 8 (February 2022): 768–779.
Aaron O’Neill, „Life expectancy (from birth) in the United States, from 1860 to 2020*,” Statistica, February 2, 2024, https://www.statista.com/statistics/1040079/life-expectancy-united-states-all-time/.
Adam Feuerstein, „In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease,” STAT News, December 8, 2023, https://www.statnews.com/2023/12/08/fda-approves-casgevy-crispr-based-medicine-for-treatment-of-sickle-cell-disease/.
Adam Feuerstein et al., „Inside ‘Project Onyx’: How Biogen used an FDA back channel to win approval of its polarizing Alzheimer’s drug,” STAT News, June 29, 2021, https://www.statnews.com/2021/06/29/biogen-fda-alzheimers-drug-approval-aduhelm-project-onyx/.
Adam Satariano et al., „Using AI to detect breast cancer that doctors miss,” New York Times, March 5, 2023, https://www.nytimes.com/2023/03/05/technology/artificial-intelligence-breast-cancer-detection.html.
Adam Schroer et al., „Platelet factors attenuate inflammation and rescue cognition in ageing,” Nature 620, no. 7976 (August 2023): 1071–1079.
Adam Widman et al., „Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment,” Nature Medicine 30, no. 6 (June 2024): 1655–1666.
Adam Yala et al., „A deep learning mammography-based model for improved breast cancer risk prediction,” Radiology 292, no. 1 (July 2019): 60–66.
Adam Yala et al., „Multi-institutional validation of a mammography-based breast cancer risk model,” Journal of Clinical Oncology 40, no. 16 (June 2022): 1732–1740.
Adam Yala et al., „Optimizing risk-based breast cancer screening policies with reinforcement learning,” Nature Medicine 28, no. 1 (January 2022): 136–143.
Aditya Raguram et al., „Therapeutic in vivo delivery of gene editing agents,” Cell 185, no. 15 (July 2022): 2806–2827.
Adrian Liston et al., „Human immune diversity: From evolution to modernity,” Nature Immunology 22, no. 12 (December 2021): 1479–1489.
Adrienne Boire et al., „Why do patients with cancer die?,” Nature Re-views Cancer 24, no. 8 (August 2024): 578–589.
Aernoud Fiolet et al., „Efficacy and safety of low-dose colchicine in patients with coronary disease: A systematic review and meta-analysis of randomized trials,” European Heart Journal 42, no. 28 (July 2021): 2765–2775.
Agostino Petroni, „Can fasting help you live to 100?,” June 7, 2024, https://www.economist.com/1843/2024/06/07/can-fasting-help-you-live-to-100.
Ahmad Jayedi et al., „Walking speed and the risk of type 2 diabetes: A systematic review and meta-analysis,” British Journal of Sports Medicine 58, no. 6 (March 2024): 334–342, https://doi.org/10.1136/bjsports-2023-107336.
Aimee Parker et al., „Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain,” Microbiome 10, no. 1 (April 2022): 68.
Ake Lu et al., „DNA methylation Grim Age strongly predicts lifespan and healthspan,” Aging 11, no. 2 (January 2019): 303–327.
Akshaya Annapragada et al., „Genome-wide repeat landscapes in cancer and cell-free DNA,” Science Translational Medicine 16, no. 738 (March 2024): eadj9283.
Alana Horowitz et al., „Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain,” Science 369, no. 6500 (July 2020): 167–173.
Alana O’Mara et al., „Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity,” Journal of Clinical Investigation 130, no. 5 (May 2020): 2209–2219.
Alan Melcher et al., „Oncolytic virotherapy as immunotherapy,” Science 374, no. 6573 (December 2021): 1325–1326.
Albert Davis et al., „Apoe genotype regulates pathology and disease progression in synucleinopathy,” Science Translational Medicine 12, no. 529 (February 2020): eaay3069.
Alberto Papi et al., „Respiratory syncytial virus prefusion F protein vaccine in older adults,” New England Journal of Medicine 388, no. 7 (February 2023): 595–608.
Alejandro Ocampo et al., „In vivo amelioration of age-associated hallmarks by partial reprogramming,” Cell 167, no. 7 (December 2016): 1719–1733 e12.
Aleksandra Petrovic Fabijan et al., „Translating phage therapy into the clinic: Recent accomplishments but continuing challenges,” PLoS Biology 21, no. 5 (May 2023): e3002119.
Alessandro Fania et al., „Machine learning and XAI approaches highlight the strong connection between O3 and NO2 pollutants and Alzheimer’s disease,” Scientific Reports 14, no. 1 (March 2024): 5385.
Alessandro Sparacio et al., „Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study,” Nature Human Behaviour (June 2024).
Alessio Crippa et al., „Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: A dose-response meta-analysis,” American Journal of Epidemiol-ogy 180, no. 8 (October 2014): 763–775.
Alessio David Nahmad et al., „Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage,” Nature Biotechnology 40, no. 12 (December 2022): 1807–1813.
Alexander Gorelick et al., „Mutational clocks tick differently across species,” Nature 604, no. 7906 (April 2022): 435–436.
Alexander Merleev et al., „A site-specific map of the human plasma glycome and its age and gender-associated alterations,” Scientific Reports 10, no. 1 (October 2020): 17505.
Alexandra Piotrowski-Daspit et al., „In vivo correction of cystic fibrosis mediated by pna nanoparticles,” Science Advances 8, no. 40 (October 2022): eabo0522.
Alexandre Bolze et al., „The potential of genetics in identifying women at lower risk of breast cancer,” JAMA Oncology 10, no. 2 (February 2024): 236–239.
Alex Cagan et al., „Somatic mutation rates scale with lifespan across mammals,” Nature 604, no. 7906 (April 2022): 517–524.
Alex Eccleston, „Non-antibiotic drug network reveals new leads for antibiotics,” Nature Reviews Drug Discovery 23, no. 5 (May 2024): 339-.
Alex Janin, „The blood tests that can flag your hidden heart disease risk,” Wall Street Journal, July 30, 2024, https://www.wsj.com/health/wellness/blood-tests-heart-disease-20d4d2f0?st=0myw3wmgfsydvad.
Alex Janin, „Waste of money or worth it? Longevity treatments at your gym,” Wall Street Journal, December 15, 2023, https://www.wsj.com/health/wellness/gym-longevity-clinic-membership-02b2f33a.
Alex Janin, „Your healthspan is as important as your lifespan—and it’s declining,” Wall Street Journal, January 17, 2024, https://www.wsj.com/health/wellness/americans-unhealthy-chronic-disease-3f35c9f5.
Alex Janin et al., „The longevity vacation: Poolside lounging with an IV drip,” Wall Street Journal, April 15, 2024, https://www.wsj.com/health/wellness/living-longer-vacation-longevity-8fa3530f.
Alex Orlando, „Why does the keto diet cause brain fog?,” Discover Magazine, December 8, 2023, https://www.discovermagazine.com/health/why-does-the-keto-diet-cause-brain-fog.
Alex Steimle et al., „Gut microbial factors predict disease severity in a mouse model of multiple sclerosis,” Nature Microbiology (July 2024).
Ali Bashashati et al., „AI for prostate cancer diagnosis – hype or today’s reality?,” Nature Reviews Urology 19, no. 5 (May 2022): 261–262
Alice Bertocchi et al., „A viral cocktail calms gut inflammation,” Nature 612, no. 7939 (December 2022): 220–221.
Alice Callahan, „Are low-fat dairy products really healthier?,” New York Times, December 8, 2023, https://www.nytimes.com/2023/12/08/well/eat/low-fat-dairy-prod ucts.html.
Alice Callahan et al., „What we know about multivitamins and memory,” New York Times, January 18, 2024, https://www.nytimes.com/2024/01/18/well/live/multivitamin-memory-supplement.html?searchResultPosition=3.
Alice Tang et al., „Leveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights,” Nature Aging 4, no. 3 (March 2024): 379–395.
Alicia Braxton et al., „3D genomic mapping reveals multifocality of human pancreatic precancers,” Nature 629, no. 8012 (May 2024): 679–687.
Alireza Atri et al., „Evoke and evoke+: Design of two large-scale, double-blind, placebo-controlled, Phase 3 studies evaluating the neuroprotective effects of semaglutide in early Alzheimer’s disease,” Alzheimer’s & Dementia 18, no. S10 (2022): e062415.
Ali Rezai et al., „Ultrasound blood-brain barrier opening and aducanumab in Alzheimer’s disease,” New England Journal of Medicine 390, no. 1 (January 2024): 55–62.
Alisha Haridasani Gupta et al., „Is delaying menopause the key to longevity?,” New York Times, June 24, 2024, https://www.nytimes.com/2024/06/24/well/live/menopause-ovaries-womens-health-longevity.html.
Alison Abbott, „Conquering Alzheimer’s: A look at the therapies of the future,” Nature 616, no. 7955 (April 2023): 26–28.
Ali Torkamani et al., „Molecular autopsy for sudden unexpected death,” JAMA 316, no. 14 (October 11, 2016): 1492–1494.
Allison Abbott, „Hacking the immune system could slow ageing—here’s how,” Nature 629, no. 8011 (May 2024): 276–278.
Allison Aiello et al., „Familial loss of a loved one and biological aging: NIMHD social epigenomics program,” JAMA Network Open 7, no. 7 (2024): e2421869-e69.
Allison DeAngelis, „Biotech launches with $82 million for Parkinson’s cell therapy,” STAT News, February 29, 2024, https://www.statnews.com/2024/02/29/kenai-therapeutics-parkinsons-disease-stem-cell-therapy/.
Allison DeAngelis, „CRISPR pioneer Feng Zhang launches new genetic delivery startup with $193 million,” STAT News, February 16, 2023, https://www.statnews.com/2023/02/16/feng-zhang-aera/.
Allison DeAngelis, „Feng Zhang, Grail founder join forces on new gene editing startup, Moonwalk,” STAT News, January 4, 2024, https://www.statnews.com/2024/01/04/feng-zhang-grail-founder-join-forces-on-new-gene-editing-startup-moonwalk/.
Allison DeAngelis, „Startup BioAge raises $170 million Series D for Zepbound combination therapy,” STAT News, February 13, 2024, https://www.statnews.com/2024/02/13/bioage-zepbound-combination-therapy/.
Alon Millet et al., „An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains,” Immunity 57, no. 1 (January 2024): 153–170.e6.
Alysha Thompson et al., „Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort,” Nutrition & Diabetes 14, no. 1 (May 2024): 32.
Amal Wanigatunga et al., „Association of total daily physical activity and fragmented physical activity with mortality in older adults,” JAMA Network Open 2, no. 10 (October 2019): e1912352.
Amanda Adler et al., „Live to eat and eat to live longer,” Nature Food 4, no. 12 (December 2023): 1029–1030.
Amanda Loudin, „Take the 30-second power test,” New York Times, January 22, 2024, https://www.nytimes.com/2024/01/22/well/move/strength-30-second-power-test-aging.html.
Amanda Loudin, „The power-building workout,” New York Times, Jan-uary 22, 2024, https://www.nytimes.com/2024/01/22/well/move/power-strength-aging-workout.html.
Amber Bahorik et al., „Association of changes in C-reactive protein level trajectories through early adulthood with cognitive function at midlife,” Neurology 103, no. 2 (2024): e209526.
Amelia Fryer et al., „The complexity of the cGAS-STING pathway in CNS pathologies,” Frontiers in Neuroscience 15 (February 2021): 621501.
AM Espinosa-Oliva et al., „Inflammatory bowel disease induces pathological alpha-synuclein aggregation in the human gut and brain,” Neuropathology and Ap-plied Neurobiology 50, no. 1 (February 2024): e12962.
Amir Jassim et al., „Cancers make their own luck: Theories of cancer origins,” Nature Reviews Cancer 23, no. 10 (October 2023): 710–724.
Amit Bar-Or et al., „Guilty by association: Epstein-Barr virus in multiple sclerosis,” Nature Medicine 28, no. 5 (May 2022): 904–6.
Amy Klein, „An Ozempic baby boom? Some GLP-1 users report unexpected pregnancies,” Washington Post, April 5, 2024, https://www.washingtonpost.com/wellness/2024/04/05/ozempic-babies-weight-loss-fertility/.
Amy Maxmen, „Questionable „young blood” transfusions offered in U.S. as anti-aging remedy,” Technology Review, January 13, 2017, https://www.technologyreview.com/2017/01/13/69219/questionable-young-blood-transfusions-offered-in-us-as-anti-aging-remedy/.
Amy Mullee et al., „Association between soft drink consumption and mortality in 10 European countries,” JAMA Internal Medicine 179, no. 11 (November 2019): 1479–1490.
Anahad O’Connor, „How drinking coffee may lower your risk for diabetes,” February 27, 2024, https://www.washingtonpost.com/wellness/2024/02/27/coffee-diabetes-health-benefits/.
Anahad O’Connor, „Look for these 9 red flags to identify food that is ultra-processed,” January 2, 2024, https://www.washingtonpost.com/wellness/2024/01/02/ultra-processed-foods-identification/.
Anahad O’Connor, „The keto diet is popular, but is it good for you?,” New York Times, August 20, 2019, https://www.nytimes.com/2019/08/20/well/eat/the-keto-diet-is-popular-but-is-it-good-for-you.html.
Anahad O’Connor, „What’s the best diet for your body? A federal study aims to find out,” Washington Post, October 24, 2023, https://www.washingtonpost.com/wellness/2023/10/24/what-is-the-best-diet-nih-study/.
Anahad O’Connor et al., „Melted, pounded, extruded: Why many ultra-processed foods are unhealthy,” Washington Post, June 27, 2023, https://www.washingtonpost.com/wellness/2023/06/27/ultra-processed-foods-predigested-health-risks/.
Anais Rico-Campa et al., „Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study,” British Medical Journal 365 (May 2019): l1949.
Ana Ortega-Molina et al., „A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan,” Nature Aging 4, no. 8 (August 2024): 1102–1120.
Anastasia Benedyk et al., „Real-life behavioral and neural circuit markers of physical activity as a compensatory mechanism for social isolation,” Nature Mental Health 2 (February 2024): 337–342.
Anastasia Shindyapina et al., „Germline burden of rare damaging variants negatively affects human healthspan and lifespan,” eLife 9 (April 2020).
Andrea Cercek et al., „PD-1 blockade in mismatch repair-deficient, locally advanced rectal cancer,” New England Journal of Medicine 386, no. 25 (June 2022): 2363–2376.
Andrea Di Francesco et al., „A time to fast,” Science 362, no. 6416 (November 2018): 770–775.
Andrea Petersen, „What, exactly, should you eat? Inside the $190 mil-lion study trying to find the answer,” Wall Street Journal, February 12, 2024, https://www.wsj.com/health/wellness/healthy-diet-nutrition-study-national-institutes-of-health-42d81da3.
Andrea Saglietto et al., „Glucagon-like peptide-1 receptor agonist semaglutide reduces atrial fibrillation incidence: A systematic review and meta-analysis,” European Journal of Clinical Investigation n/a, no. n/a (July 2024): https://onlinelibrary.wiley.com/doi/10.1111/eci.14292.
Andreas Brödel et al., „In situ targeted base editing of bacteria in the mouse gut,” Nature (July 2024), https://doi.org/10.1038/s41586-024-07681-w.
Andreas Chai et al., „Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice,” Nature Medicine 29, no. 2 (February 2023): 401–411.
Andreas Heissel et al., „Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression,” British Journal of Sports Medicine 57, no. 16 (August 2023): 1049–1057.
Andreas Lauritzen et al., „Assessing breast cancer risk by combining AI for lesion detection and mammographic texture,” Radiology 308, no. 2 (August 2023): e230227.
Andreas Lauritzen et al., „Early indicators of the impact of using AI in mammography screening for breast cancer,” Radiology 311, no. 3 (June 2024): e232479.
Andreas Mackensen et al., „Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus,” Nature Medicine 28, no. 10 (October 2022): 2124–2132.
Andrei Deviatkin et al., „Universal flu mRNA vaccine: Promises, prospects, and problems,” Vaccines (Basel) 10, no. 5 (April 2022): 709.
Andrei Tarkhov et al., „Aging clocks, entropy, and the limits of age-reversal,” bioRxiv, October 11, 2022, https://www.biorxiv.org/content/10.1101/2022.02.06.479300v2.
Andres Barria, „Dangerous liaisons as tumour cells form synapses with neurons,” Nature 573, no. 7775 (September 2019): 499–501.
Andres Diaz-Pinto et al., „Predicting myocardial infarction through retinal scans and minimal personal information,” Nature Machine Intelligence 4, no. 1 (2022): 55–61.
Andres Mendez-Lucas et al., „Dinner is served, sir: Fighting cancer with the right diet,” Cell 184, no. 26 (December 2021): 6226–6228.
Andrew Cope et al., „Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): A randomised, double-blind, multicentre, parallel, placebo-controlled, Phase 2b clinical trial,” Lancet 403, no. 10429 (March 2024): 838–849.
Andrew Jacobs, „Microplastics are a big problem, a new film warns,” New York Times, March 9, 2024, https://www.nytimes.com/2024/03/09/health/microplastics-sxsw-health-plastic-people.html?searchResultPosition=3.
Andrew Kunzmann et al., „The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study,” PLOS Medicine 15, no. 6 (June 2018): e1002585.
Andrew Perry et al., „Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks,” Nature Medicine 30, no. 6 (June 2024): 1711–1721.
Andrew Reynolds et al., „Carbohydrate quality and human health: A series of systematic reviews and meta-analyses,” Lancet 393, no. 10170 (February 2019): 434–445.
Andrew Scott et al., „The economic value of targeting aging,” Nature Aging 1, no. 7 (July 2021): 616–623.
Andrew Siderowf et al., „Assessment of heterogeneity among participants in the Parkinson’s progression markers initiative cohort using α-synuclein seed amplification: A cross-sectional study,” Lancet Neurology 22, no. 5 (May 2023): 407–417.
Andrew Tremain et al., „Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Nature Biomedical Engineering 7, no. 9 (September 2023): 1142–1155.
Andrew Wong et al., „External validation of a widely implemented proprietary sepsis prediction model in hospitalized patients,” JAMA Internal Medicine 181, no. 8 (August 2021): 1065–1070.
Ang Cui et al., „Dictionary of immune responses to cytokines at single-cell resolution,” Nature 625, no. 7994 (January 2024): 377–384.
Angela Lek et al., „Death after high-dose rAAV9 gene therapy in a patient with Duchenne’s muscular dystrophy,” New England Journal of Medicine 389, no. 13 (September 2023): 1203–1210.
Angela Wood et al., „Risk thresholds for alcohol consumption: Combined analysis of individual-participant data for 599,912 current drinkers in 83 prospective studies,” Lancet 391, no. 10129 (April 2018): 1513–1523.
Angelo Capodici et al., „Cardiovascular health and cancer risk associated with plant based diets: An umbrella review,” PLoS One 19, no. 5 (May 2024): e0300711.
Ania Jastreboff et al., „Tirzepatide once weekly for the treatment of obesity,” New England Journal of Medicine 387, no. 3 (July 2022): 205–216.
Ania Jastreboff et al., „Triple-hormone-receptor agonist retatrutide for obesity – a Phase 2 trial,” New England Journal of Medicine 389, no. 6 (August 2023): 514–526.
Anissa Widjaja et al., „Inhibition of IL-11 signalling extends mammalian healthspan and lifespan,” Nature 632, no. 8023 (August 2024): 157–165.
Anjali Dixit et al., „Preoperative GLP-1 receptor agonist use and risk of post-operative respiratory complications,” Journal of the American Medical Association 331, no. 19 (May 2024): 1672–1673.
Ann-Kathrin Schalkamp et al., „Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis,” Nature Medicine 29, no. 8 (August 2023): 2048–2056.
Anna-Maria Globig et al., „The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion,” Nature 622, no. 7982 (October 2023): 383–392.
Annabel Walsh et al., „A collaborative realist review of remote measurement technologies for depression in young people,” Nature Human Behaviour 8, no. 3 (March 2024): 480–492.
Annalisa Merelli, „HPV vaccine study finds zero cases of cervical cancer among women vaccinated before age 14,” STAT News, January 25, 2024, https://www.statnews.com/2024/01/25/hpv-vaccine-prevent-cervical-cancer-cervarix-gardasil-study/.
Anna Marseglia et al., „Effect of the NU-AGE diet on cognitive functioning in older adults: A randomized controlled trial,” Frontiers in Physiology 9 (April 2018): 349.
Anna Offersgaard et al., „Toward a vaccine against hepatitis C virus,” Science 380, no. 6640 (April 2023): 37–38.
Anna Picca et al., „Mitophagy in human health, ageing and disease,” Nature Metabolism 5, no. 12 (December 2023): 2047–2061.
Anna Puszkarska et al., „Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency,” Nature Chemistry (May 2024).
Ann Barbier et al., „The clinical progress of mRNA vaccines and immuno-therapies,” Nature Biotechnology 40, no. 6 (June 2022): 840–854.
Anne-Julie Tessier et al., „Consumption of olive oil and diet quality and risk of dementia-related death,” JAMA Network Open 7, no. 5 (May 2024): e2410021.
Anne-Julie Tessier et al., „Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies,” Med 5, no. 3 (March 2024): 224–238 e5.
Anne-Kristin Heninger et al., „A divergent population of autoantigen-responsive CD4(+) T cells in infants prior to beta cell autoimmunity,” Science Translational Medicine 9, no. 378 (February 2017): eaaf8848.
Anne Maher, „NOVA food classification,” TheUrbanCo-Op, February 6, 2023, https://www.theurbanco-op.ie/blogs/nova-food-classification.
Annette van der Helm-van Mil, „Abatacept in individuals with autoantibody-positive arthralgia at risk for rheumatoid arthritis,” Lancet 403, no. 10429 (March 2024): 785–787.
Anne Visser et al., „Tackling vascular risk factors as a possible disease modifying intervention in Parkinson’s disease,” npj Parkinson’s Disease 10, no. 1 (March 2024): 50.
Ann Falsey et al., „Efficacy and safety of an Ad26.RSV.preF-RSV preF protein vaccine in older adults,” New England Journal of Medicine 388, no. 7 (February 2023): 609–620.
Annika Kim Constantino, „Moderna, Merck vaccine with Keytruda cuts risk of deadly skin cancer returning in half, data says,” CNBC, December 14, 2023, https://www.cnbc.com/2023/12/14/moderna-merck-cancer-vaccine-reduces-risk-of-skin-cancer-return.html.
Annika Kim Constantino, „Novo Nordisk says 80% of insured U.S. Patients taking Wegovy pay less than $25 a month,” CNBC, November 2, 2023, https://www.cnbc.com/2023/11/02/wegovy-insured-patients-25-dollars-month.html.
Anqi Wang et al., „Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants,” Nature Genetics 55, no. 12 (December 2023): 2065–2074.
Anthony Fauci et al., „From mRNA sensing to vaccines,” Immunity 54, no. 12 (December 2021): 2676–2680.
Antimicrobial Resistance Collaborators, „Global burden of bacterial anti-microbial resistance in 2019: A systematic analysis,” Lancet 399, no. 10325 (February 2022): 629–655.
Anton Berns, „Transforming lung cancer types,” Science 383, no. 6683 (February 2024): 590–591.
Antonio Regalado, „Vertex developed a CRISPR cure. It’s already on the hunt for something better,” MIT Technology Review, December 15, 2023, https://www.technologyreview.com/2023/12/15/1085380/vertex-sickle-cell-pill-treatment/.
Anupriya Singhal et al., „Targeting KRAS in cancer,” Nature Medicine 30, no. 4 (April 2024): 969–983.
Araceli Boraita et al., „Incidence of atrial fibrillation in elite athletes,” JAMA Cardiology 3, no. 12 (2018): 1200–1205.
Arnout Bruggeman et al., „Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson’s disease (GUT-PARFECT): A double-blind, placebo-controlled, randomised, Phase 2 trial,” EClinicalMedicine 71 (May 2024): 102563.
Arya Aminorroaya et al., „Development and multinational validation of an algorithmic strategy for high lp(a) screening,” Nature Cardiovascular Research 3, no. 5 (May 2024): 558–566.
Asher Mullard, „These 3D model brains with cells from several people are first of their kind,” Nature 631, no. 8019 (July 2024): 16.
Ashish Sharma et al., „Cognitive reframing of negative thoughts through human-language model interaction,” arXiv (May 2023).
Ashish Vaswani et al., „Attention is all you need,” arXiv, June 12, 2017.
Ashley Capoot, „Patients are lining up for $2,500 full-body MRI scans that can detect cancer early,” CNBC, November 10, 2023, https://www.cnbc.com/2023/11/10/prenuvo-offers-2500-full-body-mri-scans-that-can-detect-cancer-early.html.
Ashley Harms et al., „Central and peripheral innate and adaptive immunity in Parkinson’s disease,” Science Translational Medicine 15, no. 721 (November 2023): eadk3225.
Asma Salari-Moghaddam et al., „Glycemic index, glycemic load, and depression: A systematic review and meta-analysis,” European Journal of Clinical Nutrition 73, no. 3 (March 2019): 356–365.
ASM Zisanur Rahman et al., „A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery,” PLOS Computational Biology 18, no. 10 (October 2022): e1010613.
Assaf Gottlieb et al., „Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells,” Proceedings of the National Academy of Sciences of the USA 121, no. 3 (January 2024): e2315857121.
Athina-Marina Metaxa et al., „Efficacy of psilocybin for treating symptoms of depression: Systematic review and meta-analysis,” BMJ 385 (2024): e078084.
Atsushi Nohara et al., „Homozygous familial hypercholesterolemia,” Journal of Atherosclerosis and Thrombosis 28, no. 7 (July 1, 2021): 665–678.
Atul Malhotra et al., „Tirzepatide for the treatment of obstructive sleep apnea and obesity,” New England Journal of Medicine (June 2024), https://doi.org/10.1056/NEJMoa2404881.
Aura Ferreiro et al., „Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease,” Science Translational Medicine 15, no. 700 (June 2023): eabo2984.
Austin Wesevich et al., „An ethical and financial obligation for sickle cell disease gene therapy in the United States,” Annals of Internal Medicine 177, no. 1 (January 2024): 85–86.
Axel Brandes et al., „Consumer-led screening for atrial fibrillation: Frontier review of the af-screen international collaboration,” Circulation 146, no. 19 (November 2022): 1461–1474.
Axel Montagne et al., „APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline,” Nature 581, no. 7806 (May 2020): 71–76.
Axel Schambach et al., „A new age of precision gene therapy,” Lancet 403, no. 10426 (February 2024): 568–582.
Ayana Archie, „The FDA proposes banning a food additive that’s been used for a century,” NPR, November 3, 2023, https://www.npr.org/2023/11/03/1210521705/fda-brominated-vegetable-oil-bvo-food-additive-california.
Ayelet Alpert et al., „A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring,” Nature Medicine 25, no. 3 (March 2019): 487–495.
Barclay Bram, „My therapist, the robot,” New York Times, September 27, 2022, https://www.nytimes.com/2022/09/27/opinion/chatbot-therapy-mental-health.html.
Barney Graham, „The journey to RSV vaccines—heralding an era of structure-based design,” New England Journal of Medicine 388, no. 7 (February 2023): 579–581.
Barney Graham et al., „Novel vaccine technologies: Essential components of an adequate response to emerging viral diseases,” JAMA 319, no. 14 (April 2018): 1431–1432.
Barry Franklin et al., „Exercise-related acute cardiovascular events and potential deleterious adaptations following long-term exercise training: Placing the risks into perspective-an update: A scientific statement from the American heart association,” Circulation 141, no. 13 (March 2020): e705–e36.
Bart Eggen, „How the cGAS-STING system links inflammation and cognitive decline,” Nature News & Views, August 2, 2023, https://www.nature.com/articles/d41586-023-02240-1.
Bartley Griffith et al., „Genetically modified porcine-to-human cardiac xeno-transplantation,” New England Journal of Medicine 387, no. 1 (July 2022): 35–44.
Beate Kampmann et al., „Bivalent prefusion F vaccine in pregnancy to prevent RSV illness in infants,” New England Journal of Medicine 388, no. 16 (April 2023): 1451–1464.
Beeke Wienert et al., „CRISPR nuclease off-target activity and mitigation strategies,” Frontiers in Genome Editing 4 (November 2022): 1050507.
Belinda Lennerz et al., „Carbohydrate restriction for diabetes: Rediscovering centuries-old wisdom,” Journal of Clinical Investigation 131, no. 1 (January 2021): e142246.
Benjamin Hale et al., „Cellular architecture shapes the naïve T cell response,” Science 384, no. 6700 (2024): eadh8697.
Benjamin Koh et al., „Patterns in cancer incidence among people younger than 50 years in the US, 2010 to 2019,” JAMA Network Open 6, no. 8 (August 2023): e2328171.
Benjamin Plackett, „Why big pharma has abandoned antibiotics,” Nature News, October 21, 2020, https://www.nature.com/articles/d41586-020-02884-3.
Benjamin Ryan, „A 7th person with HIV is probably cured after stem cell transplant for leukemia, scientists say,” NBC News, July 18, 2024, https://www.nbcnews.com/health/health-news/7th-person-hiv-cured-stem-cell-transplant-leukemia-scientists-say-rcna161897.
Benjamin Solomon et al., „Lorlatinib versus crizotinib in patients with advanced alk-positive non–small cell lung cancer: 5-year outcomes from the Phase III crown study,” Journal of Clinical Oncology 42, no. 29 (October 2024): JCO.24.00581.
Bennett Childs et al., „Senescent cells suppress innate smooth muscle cell re-pair functions in atherosclerosis,” Nature Aging 1, no. 8 (August 2021): 698–714.
Benoit Lehallier et al., „Undulating changes in human plasma proteome profiles across the lifespan,” Nature Medicine 25, no. 12 (December 2019): 1843–1850.
Ben Singh et al., „Systematic review and meta-analysis of the effectiveness of chatbots on lifestyle behaviours,” NPJ Digital Medicine 6, no. 1 (June 2023): 118.
Bernard Srour et al., „Ultra-processed food intake and risk of cardiovascular dis-ease: Prospective cohort study (NutriNet-Sante),” British Medical Journal 365 (May 2019): l1451.
Betsy Ladyzhets, „What toilets can reveal about Covid, cancer and other health threats,” Nature 628, no. 8008 (April 2024): 492–494.
Betsy Reed, „Most US sandwich baggies contain toxic PFAS ‘forever chemicals,’ analysis says,” Guardian, March 14, 2024, https://www.theguardian.com/environment/2024/mar/14/plastic-sandwich-bags-pfas-chemicals.
Betsy Reed, „New study reveals diet link to PFAS ‘forever chemicals’ in human body,” Guardian, February 19, 2024.
Bhargavi Sundaresan et al., „The role of viral infections in the onset of autoimmune diseases,” Viruses 15, no. 3 (March 2023): 782.
Bingjie Chen et al., „Contribution of pks+ E. Coli mutations to colorectal carcinogenesis,” Nature Communications 14, no. 1 (November 2023): 7827.
Bohan Zhang et al., „Multiomic rejuvenation and life span extension on exposure to youthful circulation,” Nature Aging 3, no. 8 (August 2023): 948–964.
Bo Konings et al., „Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: Testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases,” Gut 72, no. 11 (November 2023): 2103–2111.
Borja Del Pozo Cruz et al., „Association of daily step count and intensity with incident dementia in 78 430 adults living in the UK,” JAMA Neurology 79, no. 10 (October 2022): 1059–1063.
Bowen Tang et al., „Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: An emulated trial study,” EClinicalMedicine 73, no. 102689 (July 2024).
Brady Page et al., „Digitising the outbreak,” Lancet 402, no. 10418 (December 2023): 2186.
Brenda Gonzalez et al., „High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity,” Geroscience 45, no. 1 (February 2023): 311–330.
Brenda Goodman, „How a gene test could be the first step toward precision medicine for obesity,” CNN, May 23, 2024, https://www.cnn.com/2024/05/20/health/gene-test-success-weight-loss-medications/index.html#.
Brian A. Bergmark et al., „Olezarsen for hypertriglyceridemia in patients at high cardiovascular risk,” New England Journal of Medicine 390, no. 19 (2024): 1770–1780.
Brian A. Ference et al., „The LDL cumulative exposure hypothesis: Evidence and practical applications,” Nature Reviews Cardiology (July 2024).
Brian Gromley, „Startups are using AI to predict responses to cancer drugs,” Wall Street Journal, December 28, 2023, https://www.wsj.com/articles/startups-are-using-ai-to-predict-responses-to-cancer-drugs-d7fb06eb.
Brianna Abbott, „Many cancers are on the rise in the U.S., even as overall deaths fall,” Wall Street Journal, January 17, 2024, https://www.wsj.com/health/healthcare/cancer-deaths-rates-prevention-f73c82a4.
Bridget Balch, „Sepsis is the third leading cause of death in U.S. Hospitals. But quick action can save lives,” AAMC, October 10, 2023, https://www.aamc.org/news/sepsis-third-leading-cause-death-us-hospitals-quick-action-can-save-lives#:~:text=That%20immune%20response%2C%20known%20as,Control%20and%20Prevention%20(CDC).
Brit Mollenhauer et al., „Toward pre-venting Parkinson’s disease,” Science 377, no. 6608 (August 2022): 818–819.
Bruce Ames, „Prolonging healthy aging: Longevity vitamins and proteins,” Proceedings of the National Academy of Sciences of the USA 115, no. 43 (October 2018): 10836–0844, https://doi.org/10.1073/pnas.1809045115.
Bruce Gil, „A new genetic test can predict how well Ozempic will work for patients,” QZ, May 20, 2024, https://qz.com/ozempic-wegovy-genetic-test-1851488697.
Bryan Choi et al., „Intraventricular carv3-team-e t cells in recur-rent glioblastoma,” New England Journal of Medicine 390, no. 14 (2024): 1290–1298.
Brynjar Jensson et al., „Actionable genotypes and their association with life span in Iceland,” New England Journal of Medicine 389, no. 19 (November 2023): 1741–1752.
C. Ellis Wisely et al., „Convolutional neural network to identify symptomatic Alzheimer’s disease using multimodal retinal imaging,” British Journal of Ophthalmology 106, no. 3 (2022): 388–395.
C. Puricelli et al., „Cutting-edge delivery systems and adjuvants in tolerogenic vaccines: A review,” Pharmaceutics 14, no. 9 (August 25, 2022).
C. Santucci et al., „European cancer mortality predictions for the year 2024 with focus on colorectal cancer,” Annals of Oncology 35, no. 3 (March 2024): 308–316.
Caesar Li et al., „Epigenetic predictors of species maximum life span and other life-history traits in mammals,” Science Advances 10, no. 23 (June 7, 2024): eadm7273.
Cai-Yan Zou et al., „Effects of SGLT2 inhibitors on cardiovascular outcomes and mortality in type 2 diabetes: A meta-analysis,” Medicine 98, no. 49 (2019): e18245.
Cameron Adams et al., „Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans,” Proceedings of the National Academy of Sciences of the USA 121, no. 8 (February 2024): e2302259121.
Camille Lassale et al., „Healthy dietary indices and risk of depressive out-comes: A systematic review and meta-analysis of observational studies,” Molecular Psychiatry 24, no. 7 (July 2019): 965–986.
Cammie Tran et al., „Testosterone and the risk of incident atrial fibrillation in older men: Further analysis of the aspree study,” EClinicalMedicine 72 (June 2024): 102611.
Cana Park et al., „Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice,” Nature Aging 3, no. 9 (September 2023): 1067–1078.
Caoimhe Twohig-Bennett et al., „The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes,” Environ-mental Research 166 (October 2018): 628–637.
Carissa Wong, „Antibiotic resistance is a growing threat—is climate change making it worse?,” Nature (January 2024).
Carlos Lopez-Otin et al., „Hallmarks of aging: An expanding universe,” Cell 186, no. 2 (January 2023): 243–278.
Carlos Lopez-Otin et al., „Meta-hallmarks of aging and cancer,” Cell Metabolism 35, no. 1 (January 2023): 12–35.
Carlos Lopez-Otin et al., „The hallmarks of aging,” Cell 153, no. 6 (June 2013): 1194–217.
Carmen Martin-Alonso et al., „Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies,” Science 383, no. 6680 (January 2024): eadf2341.
Carmen Schaeuffele et al., „A systematic review and meta-analysis of transdiagnostic cognitive behavioural therapies for emotional disorders,” Nature Human Behaviour 8, no. 3 (March 2024): 493–509.
Carola Venturini et al., „Biological foundations of successful bacteriophage therapy,” EMBO Molecular Medicine 14, no. 7 (July 2022): e12435.
Caroline Raffin et al., „T(reg) cell-based therapies: Challenges and perspectives,” Nature Reviews Immunology 20, no. 3 (March 2020): 158–172.
Caroline Seydel, „Baby’s first genome,” Nature Biotechnology 40, no. 5 (May 2022): 636–640.
Carol Vanderlugt et al., „Epitope spreading in immune-mediated diseases: Implications for immunotherapy,” Nature Reviews Immunology 2, no. 2 (February 2002): 85–95.
Carolyn Beans, „Researchers getting closer to a ‘universal’ flu vaccine,” Proceedings of the National Academy of Sciences of the USA 119, no. 5 (February 2022): e2123477119.
Carrie Arnold, „After obesity drugs’ success, companies rush to preserve skeletal muscle,” Nature Biotechnology 42, no. 3 (March 2024): 351–353.
Carrie Arnold, „Autoimmune disease is the next frontier for CAR T cell therapy,” Nature Medicine 30, no. 1 (January 2024): 6–9.
Casey Kim et al., „Trends in primary prevention statin use by cardiovascular risk score from 1999 to 2018: A repeated cross-sectional study,” Annals of Internal Medicine 176, no. 12 (December 2023): 1684–1688.
Casey Ross, „AI can speed up drug discovery but don’t expect it to cure cancer, yet,” STAT News, February 7, 2024, https://www.statnews.com/2024/02/07/ai-drug-discovery-novartis-amgen-sanofi/.
Casey Ross, „AI gone astray: How subtle shifts in patient data send popular algorithms reeling, undermining patient safety,” STAT News, February 28, 2022, https://www.statnews.com/2022/02/28/sepsis-hospital-algorithms-data-shift/.
Cassandra Willyard, „Can autoimmune diseases be cured? Scientists see hope at last,” Nature 625, no. 7996 (January 2024): 646–648.
Cassandra Willyard, „Do cutting-edge CAR-T-cell therapies cause cancer? What the data say,” Nature 629, no. 8010 (May 2024): 22–24.
Cassandra Willyard, „The effort to make a breakthrough cancer therapy cheaper,” MIT Technology Review (April 2024), https://www.technologyreview.com/2024/04/12/1091161/car-t-cancer-therapy-treatment-expense/#:~:text=Caring%20Cross%20has%20developed%20a,leading%20to%20long%20wait%20times.
Cassandra Willyard, „The innovation that gets an Alzheimer’s drug through the blood-brain barrier,” MIT Technology Review, January 12, 2024, https://www.technologyreview.com/2024/01/12/1086442/the-innovation-that-gets-an-alzheimers-drug-through-the-blood-brain-barrier/.
Cassandra Willyard, „The X Prize is taking aim at aging with a new $101 million award,” Technology Review, November 29, 2023, https://www.technologyreview.com/2023/11/29/1084052/x-prize-aging-101-million-award/.
Caterina Conte et al., „Is weight loss–induced muscle mass loss clinically relevant?,” Journal of the American Medical Association 332, no. 1 (July 2024): 9–10.
Catherine Mummery et al., „Tau-targeting antisense oligonucleotide MAPT(Rx) in mild Alzheimer’s disease: A Phase 1b, randomized, placebo-controlled trial,” Nature Medicine 29, no. 6 (June 2023): 1437–1447
Catherine Roberts, „Produce without pesticides,” Consumer Reports, April 18, 2024, https://www.consumerreports.org/health/food-contaminants/produce-without-pesticides-a5260230325/.
Catherine Robertson et al., „Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes,” Nature Genetics 53, no. 7 (July 2021): 962–971.
Catherine Robertson et al., „Untangling the genetics of beta cell dysfunction and death in type 1 diabetes,” Molecular Metabolism 86 (August 2024): 101973.
CD Santos-Júnior et al., „Discovery of antimicrobial peptides in the global microbiome with machine learning,” Cell 187, no. 14 (July 2024): 3761–3778.e16.
Cedric Richlitzki et al., „C-reactive protein as robust laboratory value associated with prognosis in patients with stage III non-small cell lung cancer (NSCLC) treated with definitive radiochemotherapy,” Scientific Reports 14, no. 1 (June 2024): 13765.
Celia Dobersalske et al., „Cranioencephalic functional lymphoid units in glioblastoma,” Nature Medicine (July 2024).
Center for Surgery and Public Health, „Estimating annual expenditures for cancer screening in the United States,” December 2021, https://csph.brighamandwomens.org/wp-content/uploads/2021/12/Estimating-Annual-Expenditures-for-Cancer-Screening-in-the-United-States.pdf.
Centers for Disease Control and Prevention, „Chronic diseases in America,” CDC, 2022, https://www.cdc.gov/chronic-disease/?CDC_AAref_Val=https://www.cdc.gov/chronicdisease/resources/infographic/chronic-diseases.htm.
Chad Terhune, „Exclusive: Most patients using weight-loss drugs like Wegovy stop within a year, data show,” Reuters, July 11, 2023, https://www.reuters.com/business/healthcare-pharmaceuticals/most-patients-using-weight-loss-drugs-like-wegovy-stop-within-year-data-show-2023-07-11/.
Chang Liu et al., „Association between high-density lipoprotein cholesterol levels and adverse cardiovascular outcomes in high-risk populations,” JAMA Cardiology 7, no. 7 (July 2022): 672–680.
Chao-Jie Ye et al., „Mendelian randomization evidence for the causal effect of mental well-being on healthy aging,” Nature Human Behaviour (June 2024).
Chao Fang et al., „Deepan: Deep patient graph convolutional network integrating clinico-genomic evidence to stratify lung cancers for immunotherapy,” NPJ Digital Medicine 4, no. 1 (February 2021): 14.
Charilaos Chourpiliadis et al., „Metabolic profile and long-term risk of depression, anxiety, and stress-related disorders,” JAMA Network Open 7, no. 4 (April 2024): e244525.
Charles Chiu et al., „Clinical metagenomics,” Nature Reviews Genetics 20, no. 6 (June 2019): 341–355.
Charles Matthews et al., „Amount and intensity of leisure-time physical activity and lower cancer risk,” Journal of Clinical Oncology 38, no. 7 (March 2020): 686–697.
Charlotte Debras et al., „Artificial sweeteners and risk of cardiovascular diseases: Results from the prospective NutriNet-Sante cohort,” British Medical Journal 378 (September 2022): e071204.
Chelin Jamie Hu et al., „Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis,” Toxicological Sciences 200, no. 2 (2024): 235–240.
Chenchen Pan et al., „Insights and opportunities at the crossroads of cancer and neuroscience,” Nature Cell Biology 24, no. 10 (October 2022): 1454–1460.
Chenhao Li et al., „Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria,” Cell 187, no. 8 (April 2024): 1834–1852.e19.
Chih-Jen Wei et al., „A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice,” Science Translational Medicine 14, no. 643 (May 2022): eabf3685.
Chi Kin Wong et al., „Central glucagon-like peptide 1 receptor activation inhibits toll-like receptor agonist-induced inflammation,” Cell Metabolism 36, no. 1 (January 2024): 130–143 e5.
Chirag Vyas et al., „Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic subcohort of the COcoa supplement and multivitamin outcomes study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS,” American Journal of Clinical Nutrition 119, no. 3 (March 2024): 692–701.
Chonghua Xue et al., „AI-based differential diagnosis of dementia etiologies on multimodal data,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03118-z.
Chonglin Yang et al., „Lysosome biogenesis: Regulation and functions,” Journal of Cell Biology 220, no. 6 (June 2021), https://doi.org/10.1083/jcb.202102001.
Christian Paludan-Müller et al., „Atrial fibrillation: Age at diagnosis, incident cardiovascular events, and mortality,” European Heart Journal 45, no. 24 (June 2024): 2119–2129.
Christie M. Ballantyne et al., „Plozasiran, an RNA interference agent targeting apoc3, for mixed hyperlipidemia,” New England Journal of Medicine 391, no. 10 (May 28, 2024), https://doi.org/doi:10.1056/NEJMoa2404143.
Christina Caron, „How to find a mental health app that works for you,” New York Times, April 13, 2022, https://www.nytimes.com/2022/04/13/well/mind/mental-health-apps-therapy.html.
Christina Curtis, „Quantifying mutations in healthy blood,” Science 367, no. 6485 (March 2020): 1426–1427.
Christina Krienke et al., „A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis,” Science 371, no. 6525 (January 2021): 145–153.
Christine Bender et al., „A Phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes,” Science Translational Medicine 16, no. 746 (2024): eadn2404.
Christine Brown et al., „Locoregional delivery of il-13rα2-targeting CAR-T cells in recurrent high-grade glioma: A Phase 1 trial,” Nature Medicine 30, no. 4 (April 2024): 1001–1012.
Christine Wardell et al., „mRNA vaccines take on immune tolerance,” Nature Biotechnology 39, no. 4 (April 2021): 419–421.
Christopher Gibbons et al., „Skin biopsy detection of phosphorylated α-synuclein in patients with synucleinopathies,” Journal of the American Medical Association 331, no. 15 (March 2024): 1298–306.
Christopher Pan et al., „Targeting metabolism to influence aging,” Science 371, no. 6526 (January 2021): 234–35.
Christopher van Dyck et al., „Lecanemab in early Alzheimer’s disease,” New England Journal of Medicine 388, no. 1 (2023): 9–21.
Christopher Wayne et al., „Self-amplifying RNA Covid-19 vaccine,” Cell 187, no. 8 (April 2024): 1822–1822.e1.
Christoph Nowak et al., „Intralymphatic GAD-Alum (Diamyd®) im-proves glycemic control in type 1 diabetes with HLA DR3-DQ2,” Journal of Clinical Endocrinology & Metabolism 107, no. 9 (August 2022): 2644–2651.
Cian Schmitt-Ulms et al., „Programmable RNA writing with trans-splicing,” bioRxiv (2024), https://doi.org/https://doi.org/10.1101/2024.01.31.578223.
CI Edvard Smith et al., „Estimating the number of diseases—the concept of rare, ultra-rare, and hyper-rare,” iScience 25, no. 8 (August 2022): 104698.
Cinnamon Bloss et al., „A genome sequencing program for novel undiagnosed diseases,” Genetics in Medicine 17, no. 12 (December 2015): 995–1001.
Clara Depommier et al., „Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study,” Nature Medicine 25, no. 7 (July 2019): 1096–103.
Clara Salame et al., „Food additive emulsifiers and the risk of type 2 diabetes: Analysis of data from the NutriNet-Sante prospective cohort study,” Lancet Diabetes & Endocrinology 12, no. 5 (May 2024): 339–349.
Clara Schmidt et al., „Multi-chamber cardioids unravel human heart development and cardiac defects,” Cell 186, no. 25 (December 2023): 5587–605 e27.
Clare Ansberry, „U.S. no longer ranks among world’s 20 happiest countries,” Wall Street Journal, March 19, 2024, https://www.wsj.com/health/wellness/world-happiness-report-americans-top-20-0f59cf98.
Claudio Araujo et al., „Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals,” British Journal of Sports Medicine 56, no. 17 (September 2022): 975–980.
Clifford Jack et al., „Revised criteria for the diagnosis and staging of Alzheimer’s disease,” Nature Medicine (June 2024).
Clifford Jack Jr. et al., „Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: Hazard ratios and absolute risk,” Brain Communications 4, no. 2 (February 2022): fcac017.
Coleen Murphy, How We Age: The Science of Longevity (Princeton, NJ: Princeton University Press, 2023).
Colin Birkenbihl et al., „Artificial intelligence-based clustering and characterization of Parkinson’s disease trajectories,” Scientific Reports 13, no. 1 (February 2023): 2897.
Colin Dayan et al., „Preventing type 1 diabetes in childhood,” Science 373, no. 6554 (July 2021): 506–510.
Colin Espie et al., „Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: A randomized clinical trial,” JAMA Psychiatry 76, no. 1 (January 2019): 21–30.
Colin O’Brien et al., „Prevalence of aspirin use for primary prevention of cardiovascular disease in the United States: Results from the 2017 national health interview survey,” Annals of Internal Medicine 171, no. 8 (October 2019): 596–598.
Colin Zamecnik et al., „An autoantibody signature predictive for multiple sclerosis,” Nature Medicine 30, no. 5 (May 2024): 1300–1308.
Cong Liu et al., „Ambient particulate air pollution and daily mortality in 652 cities,” New England Journal of Medicine 381, no. 8 (August 2019): 705–715.
Corina Amor et al., „Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction,” Research Square (September 2023), https://doi.org/10.21203/rs.3.rs-3385749/v1.
Cornelis Blauwendraat et al., „The genetic architecture of Parkinson’s disease,” Lancet Neurol 19, no. 2 (February 2020): 170–178.
Craig Russell, „Wegovy was inspired by Gila monster venom—here are some other drugs with surprising origin,” Conversation, September 5, 2023, https://theconversation.com/wegovy-was-inspired-by-gila-monster-venom-here-are-some-other-drugs-with-surprising-origins-208630#:~:text=Scientists%20found%20that%20a%20hormone,blood%20sugar%20levels%20in%20humans.
Cristina Godinho-Silva et al., „Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis,” Nature 574, no. 7777 (October 2019): 254–258.
CT Stankey et al., „A disease-associated gene desert directs macrophage inflammation through ETS2,” Nature 630, no. 8016 (June 2024): 447–456, https://doi.org/10.1038/s41586-024-07501-1.
Cynthia Thomson et al., „Long-term effect of randomization to calcium and Vitamin D supplementation on health in older women: Postintervention follow-up of a randomized clinical trial,” Annals of Internal Medicine 177, no. 4 (April 2024): 428–438.
Céline Bellenguez et al., „New insights into the genetic etiology of Alzheimer’s disease and related dementias,” Nature Genetics 54, no. 4 (April 4, 2022): 412–436.
D. Scott Wilson et al., „Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes,” Nature Biomedical Engineering 3, no. 10 (October 2019): 817–829.
Daisy Singla, „Expanding the reach and scalability of perinatal mental health interventions,” Nature Medicine 30, no. 3 (March 2024): 638–639.
Damian Garde, „Years after a polarizing approval, Biogen walks away from Aduhelm,” STAT News, January 1, 2024, https://www.statnews.com/2024/01/31/biogen-gives-away-rights-aduhelm/.
Dana Carroll, „Genome engineering with zinc-finger nucleases,” Genetics 188, no. 4 (August 2011): 773–782.
Dana Goodyear, „Gene editing gives us transformative powers. But should we use them?,” New Yorker, September 2, 2023, https://www.newyorker.com/magazine/2023/09/11/the-transformative-alarming-power-of-gene-editing.
Dana Small et al., „Processed foods and food reward,” Science 363, no. 6425 (January 2019): 346–347.
Dana Smith, „Antidepressants don’t work the way many people think,” New York Times, November 8, 2022, https://www.nytimes.com/2022/11/08/well/mind/antidepres sants-effects-alternatives.html.
Dana Smith et al., „More evidence links ultraprocessed foods to dementia,” New York Times, July 31, 2024, https://www.nytimes.com/2024/07/31/well/eat/ultra processed-foods-brain-health.html#:~:text=Research%20tracking%20more%20than%2072%2C000,increased%20risk%20for%20developing%20dementia.
Danay Saavedra et al., „Aging and chronic inflammation: Highlights from a multidisciplinary workshop,” Immunity & Ageing 20, no. 1 (June 2023): 25.
Dani Blum, „Some people on Ozempic lose the desire to drink. Scientists are asking why,” New York Times, February 24, 2023, https://www.nytimes.com/2023/02/24/well/eat/ozempic-side-effects-alcohol.html.
Dani Blum, „The race is on to stop Ozempic muscle loss,” New York Times, February 8, 2024, https://www.nytimes.com/2024/02/08/well/live/ozempic-muscle-loss-exercise.html.
Daniela Frasca et al., „Inflammaging decreases adaptive and innate immune responses in mice and humans,” Biogerontology 17, no. 1 (February 2016): 7–19.
Daniel Ajona et al., „Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade,” Nature Cancer 1, no. 1 (January 2020): 75–85.
Daniel Belsky et al., „DunedinPACE, a DNA methylation biomarker of the pace of aging,” eLife 11 (January 14, 2022).
Daniel Belsky et al., „To promote healthy aging, focus on the environment,” Nature Aging 3, no. 11 (November 2023): 1334–1344.
Daniel Bruhm et al., „Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer,” Nature Genetics 55, no. 8 (August 2023): 1301–1310.
Daniel Drucker, „The benefits of GLP-1 drugs beyond obesity,” Science 385, no. 6706 (2024): 258–260.
Daniel Gilbert, „How a cheap, generic drug became a darling of longevity enthusiasts,” Washington Post, March 15, 2024, https://www.washingtonpost.com/business/2024/03/15/rapamycin-longevity-drug/.
Daniel Gilbert et al., „In a first, FDA authorizes AI-driven test to predict sepsis in hospitals,” Washington Post, April 3, 2024, https://www.washingtonpost.com/business/2024/04/03/fda-artificial-intelligence-sepsis/.
Daniel Gottlieb et al., „Diagnosis and management of obstructive sleep apnea: A review,” Journal of the American Medical Association 323, no. 14 (April 2020): 1389–400.
Daniel Oran et al., „The proportion of SARS-CoV-2 infections that are asymptomatic: A systematic review,” Annals of Internal Medicine 174, no. 5 (May 2021): 655–662.
Daniel Reichart et al., „Efficient in vivo genome editing prevents hyper-trophic cardiomyopathy in mice,” Nature Medicine 29, no. 2 (February 2023): 412–421.
Daniel Sirkis et al., „Role for cell death pathway in Alzheimer’s disease,” Science 381, no. 6663 (September 2023): 1156–1157.
Daniel Yetman, „How much does a coronary calcium scan cost?,” Healthline, November 9, 2022, https://www.healthline.com/health/heart/coronary-calcium-scan-cost#takeaway.
Dan Liu et al., „Association of sugar-sweetened, artificially sweetened, and un-sweetened coffee consumption with all-cause and cause-specific mortality: A large prospective cohort study,” Annals of Internal Medicine 175, no. 7 (July 2022): 909–917.
Daria Beshnova et al., „De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection,” Science Translational Medicine 12, no. 557 (Au-gust 2020): eaaz3738.
Daria Esterhazy et al., „Gut immune cells have a role in food metabolism,” Nature 566, no. 7742 (February 2019): 49–50.
Dave Chokshi, „Forget about living to 100. Let’s live healthier instead,” New York Times, September 28, 2023, https://www.nytimes.com/2023/09/28/opinion/aging-public-health-healthspan.html.
David Adam, „Ketamine is in the spotlight thanks to Elon Musk—but is it the right treatment for depression?,” Nature (March 2024): 712–713.
David Bloom et al., „Vaccination for healthy aging,” Science Translational Medicine 16, no. 745 (May 2024): eadm9183.
David Cheek et al., „Mapping the long road to cancer,” Cell 185, no. 6 (March 2022): 939–940.
David Chieng et al., „The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: Long-term outcomes from the UK Biobank,” European Journal of Preventive Cardiology 29, no. 17 (December 2022): 2240–2249.
David Crosby et al., „Early detection of cancer,” Science 375, no. 6586 (March 2022): eaay9040.
Davide Placido et al., „A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories,” Nature Medicine 29, no. 5 (May 2023): 1113–1122.
David Furman et al., „Chronic inflammation in the etiology of disease across the life span,” Nature Medicine 25, no. 12 (December 2019): 1822–1832.
David Jenkins et al., „Association of glycaemic index and glycaemic load with type 2 diabetes, cardiovascular disease, cancer, and all-cause mortality: A meta-analysis of mega cohorts of more than 100 000 participants,” Lancet Diabetes & Endocrinology 12, no. 2 (February 2024): 107–118.
David Jenkins et al., „Glycemic index, glycemic load, and cardiovascular disease and mortality,” New England Journal of Medicine 384, no. 14 (April 2021): 1312–1322.
David Jones et al., „Digitising brain age,” Lancet 400, no. 10357 (September 2022): 988.
David Killock, „Personalized neoantigen mRNA vaccine mitigates melanoma recurrence,” Nature Reviews Clinical Oncology 21, no. 3 (March 2024): 168.
David Leggat et al., „Vaccination induces HIV broadly neutralizing antibody precursors in humans,” Science 378, no. 6623 (December 2022): eadd6502
David Ludwig et al., „Dietary fat: From foe to friend?,” Science 362, no. 6416 (November 2018): 764–770.
David Meyer et al., „Aging clocks based on accumulating stochastic variation,” Nature Aging 4, no. 6 (May 2024): 871–885.
David Munro et al., „Microglia protect against age-associated brain pathologies,” Neuron (June 2024), https://doi.org/10.1016/j.neuron.2024.05.018.
David Tuveson et al., „Cancer modeling meets human organoid technology,” Science 364, no. 6444 (June 2019): 952–955.
David Wainer, „Gene editing will change medicine—and maybe health investing too,” Wall Street Journal, November 24, 2023, https://www.wsj.com/tech/biotech/gene-editing-changing-medicine-9cc02c7e?mod=Searchresults_pos4&page=1.
David Wallace-Wells, „This is what a miracle drug looks like, and it costs only $5 to make,” New York Times, April 24, 2024, https://www.nytimes.com/2024/04/24/opinion/ozempic-we govy-weight-glp1.html.
David Wilson III et al., „Hallmarks of neurodegenerative diseases,” Cell 186, no. 4 (February 2023): 693–714.
David Zeevi et al., „Personalized nutrition by prediction of glycemic responses,” Cell 163, no. 5 (November 2015): 1079–1094.
Davis Cammann et al., „Genetic correlations between Alzheimer’s disease and gut microbiome genera,” Scientific Reports 13, no. 1 (March 2023): 5258.
Dawid Zyla et al., „A neutralizing antibody prevents postfusion transition of measles virus fusion protein,” Science 384, no. 6703 (2024): eadm8693.
Dean Ornish et al., „Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: A randomized, controlled clinical trial,” Alzheimer’s Research & Therapy 16, no. 1 (June 2024): 122.
Deborah Balthazar, „Phage therapy: Researchers sharpen another arrow in the quiver against antibiotic resistance,” STAT News, February 20, 2024, https://www.statnews.com/2024/02/20/phage-therapy-research-antibiotic-resistance/.
Deborah Lee et al., „Targeting ageing with rapamycin and its derivatives in humans: A systematic review,” Lancet Healthy Longevity 5, no. 2 (February 2024): e152–e62.
Deb Schrag et al., „Blood-based tests for multicancer early detection (PATH-FINDER): A prospective cohort study,” Lancet 402, no. 10409 (October 2023): 1251–1260.
Deepak Gupta et al., „Effect of dietary sodium on blood pressure: A crossover trial,” JAMA 330, no. 23 (December 2023): 2258–2266.
Delger Erdenesanaa, „PFAS ‘forever chemicals’ are pervasive in water worldwide, study finds,” New York Times, April 8, 2024, https://www.nytimes.com/2024/04/08/climate/pfas-forever-chemicals-water.html#:~:text=chemicals%2Dwater.html-,PFAS%20’Forever%20Chemicals’%20Are%20Pervasive%20in%20Water%20Worldwide%2C%20Study,any%20 obvious%20source%20of%20contamination.&text=They’re%20in%20makeup%2C%20d ental,pans%20and%20takeout%20food%20wrappers.
Dena Dubal et al., „Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice,” Journal of Neuroscience 35, no. 6 (February 2015): 2358–2371.
Dena Zeraatkar et al., „Effect of lower versus higher red meat intake on cardiometabolic and cancer outcomes: A systematic review of randomized trials,” Annals of Internal Medicine 171, no. 10 (November 2019): 721–731.
Denise Grady, „Every virus a person has had can be seen in a drop of blood, researchers find,” New York Times, June 4, 2015, https://www.nytimes.com/2015/06/05/health/single-blood-test-for-all-virus-exposures.html?_r=0.
Denise Houston et al., „Protein intake and mobility limitation in community-dwelling older adults: The health abc study,” Journal of the American Geriatrics Society 65, no. 8 (August 2017): 1705–1711.
Denise Kviatcovsky et al., „Phage therapy in noncommunicable diseases,” Science 382, no. 6668 (October 2023): 266–267.
Dennis Burton et al., „Toward superhuman SARS-CoV-2 immunity?,” Nature Medicine 27, no. 1 (January 2021): 5–6.
Dennis Burton et al., „Variant-proof vaccines—invest now for the next pandemic,” Nature 590, no. 7846 (February 2021): 386–388.
Derek Lowe, „The serotonin hypothesis lives,” In the Pipeline, Science, December 4, 2023, https://www.science.org/content/blog-post/serotonin-hypothesis-lives.
Desana Kocevska et al., „Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: A systematic review and meta-analysis,” Nature Human Behaviour 5, no. 1 (January 2021): 113–122.
Desiree Bock et al., „In vivo prime editing of a metabolic liver disease in mice,” Science Translational Medicine 14, no. 636 (March 16, 2022): eabl9238.
Dhruv Khullar, „Will a full-body MRI scan help you or hurt you?,” New Yorker, January 12, 2024, https://www.newyorker.com/science/annals-of-medicine/will-a-full-body-mri-scan-help-you-or-hurt-you.
Diana Cardenas, „Let not thy food be confused with thy medicine: The Hippocratic misquotation,” 2013, https://clinicalnutritionespen.com/article/S2212-8263(13)00092-4/abstract.
Diana De Oliveira-Gomes et al., „Apolipoprotein B: Bridging the gap between evidence and clinical practice,” Circulation 150, no. 1 (2024): 62–79.
Diana Dou et al., „Xist ribonucleoproteins promote female sex-biased autoimmunity,” Cell 187, no. 3 (February 2024): 733–749 e16.
Diane Quagliani et al., „Closing America’s fiber intake gap: Communication strategies from a food and fiber summit,” American College of Lifestyle Medicine 11, no. 1 (January–February 2017): 80–85.
Dilan Athauda et al., „Exenatide once weekly versus placebo in Parkinson’s disease: A randomised, double-blind, placebo-controlled trial,” Lancet 390, no. 10103 (October 2017): 1664–1675.
Dimitrios Kapogiannis et al., „Brain responses to intermittent fasting and the healthy living diet in older adults,” Cell Metabolism 36, no. 8 (August 2024): 1668–1678.e5.
Dingjiacheng Jia et al., „Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer,” Cell 187, no. 7 (March 2024): 1651–1665. e21.
Divij Mathew et al., „Combined JAK inhibition and PD-1 immuno-therapy for non–small cell lung cancer patients,” Science 384, no. 6702 (2024): eadf1329.
Dmitrii Kriukov et al., „Computagebench: Epigenetic aging clocks benchmark,” bioRxiv (June 2024), https://doi.org/https://doi.org/10.1101/2024.06.06.597715.
Domenica Taruscio et al., „Rare diseases: Challenges and opportunities for research and public health,” Nature Reviews Disease Primers 10, no. 1 (February 2024): 13.
Dominik Linz et al., „Atrial fibrillation: Epidemiology, screening and digital health,” Lancet Regional Health – Europe 37 (February 2024): 100786.
Donald Lloyd-Jones et al., „Life’s essential 8: Updating and enhancing the American heart association’s construct of cardiovascular health: A presidential advisory from the American Heart Association,” Circulation 146, no. 5 (August 2022): e18–e43.
Dong Hoon Lee et al., „Long-term leisure-time physical activity intensity and all-cause and cause-specific mortality: A prospective cohort of US adults,” Circulation 146, no. 7 (August 2022): 523–534.
Dongmei Cao et al., „Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders,” Neuron 112, no. 4 (February 2024): 526–538.
Dong Sun et al., „Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases,” Nature Human Behaviour (July 2024).
Dong Wang et al., „Association of specific dietary fats with total and cause-specific mortality,” JAMA Internal Medicine 176, no. 8 (August 2016): 1134–1145.
Donna Ryan et al., „Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial,” Nature Medicine (May 2024).
Doron Aronson et al., „How hyperglycemia promotes atherosclerosis: Molecular mechanisms,” Cardiovascular Diabetology 1 (April 2002): 1.
Douglas Hanahan et al., „Cancer hallmarks intersect with neuroscience in the tumor microenvironment,” Cancer Cell 41, no. 3 (March 2023): 573–580.
E. Piperni et al., „Intestinal blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries,” Cell (July 2024), https://doi.org/10.1016/j.cell.2024.06.018.
EA Sims et al., „Endocrine and metabolic effects of experimental obesity in man,” Recent Progress in Hormone Research 29 (1973): 457–496.
Eddie Cano-Gamez et al., „An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression,” Science Translational Medicine 14, no. 669 (November 2022): eabq4433.
Edson Moreira Jr. et al., „Safety and efficacy of a third dose of BNT162b2 Covid-19 vaccine,” New England Journal of Medicine 386, no. 20 (May 2022): 1910–1921.
Eduard Shantsila et al., „Atrial fibrillation: Comorbidities, lifestyle, and patient factors,” Lancet Regional Health – Europe 37 (February 2024): 100784.
Edward De Brouwer et al., „Machine-learning-based prediction of disability progression in multiple sclerosis: An observational, international, multi-center study,” PLOS Digital Health 3, no. 7 (July 2024): e0000533.
Edward Gregg et al., „The burden of diabetes-associated multiple long-term conditions on years of life spent and lost,” Nature Medicine (August 2024), https://doi.org/10.1038/s41591-024-03123-2.
Edward Walsh et al., „Efficacy and safety of a bivalent RSV prefusion F vaccine in older adults,” New England Journal of Medicine 388, no. 16 (April 2023): 1465–1477.
Edwin Neumann et al., „Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor,” Science 384, no. 6703 (2024): ado7082.
Ehsan Shokri-Kojori et al., „Beta-amyloid accumulation in the human brain after one night of sleep deprivation,” Proceedings of the National Academy of Sciences of the USA 115, no. 17 (April 2018): 4483–4488.
Eirik Degerud et al., „Life course socioeconomic position, alcohol drinking patterns in midlife, and cardiovascular mortality: Analysis of Norwegian population-based health surveys,” PLOS Medicine 15, no. 1 (January 2018): e1002476.
Ekaterina Brynzak-Schreiber et al., „Microplastics role in cell migration and distribution during cancer cell division,” Chemosphere 353 (April 2024): 141463.
Elaine Chen, „A ‘vaccine-like’ version of Wegovy is on the drawing board at Novo Nordisk,” STAT News, February 29, 2024, https://www.statnews.com/2024/02/29/obesity-vaccine-wegovy-novo-nordisk/
Elaine Chen, „Can Wegovy treat depression as well as obesity? New research looks to GLP-1 drugs for mental illnesses,” STAT News, January 30, 2024, https://www.statnews.com/2024/01/30/wegovy-ozempic-depression-bipolar/#:~:text=Early%20data%20and%20anecdotes%20suggest,ability%20to%20focus%20and%20plan.
Elaine Chen, „Older GLP-1 drug may help protect brains of Alzheimer’s patients, early study suggests,” July 30, 2024, https://www.statnews.com/2024/07/30/liraglutide-alzheimers-brain-study-ozempic-wegovy/.
Elaine Chen, „Study links Ozempic to higher risk of eye condition that can cause vision loss,” STAT News, July 3, 2024, https://www.statnews.com/2024/07/03/ozempic-wegovy-naion-vision-loss-study/.
Elaine Chen et al., „The Ozempic revolution is rooted in the work of Svetlana Mojsov, yet she’s been edged out of the story,” STAT News, September 27, 2023, https://www.statnews.com/2023/09/27/weight-loss-obesity-glp1-svetlana-mojsov/.
Elena Katsyuba et al., „NAD(+) homeostasis in health and disease,” Nature Metabolism 2, no. 1 (January 2020): 9–31.
Eli Adashi et al., „Mitochondrial disease: Replace or edit?,” Science 373, no. 6560 (September 2021): 1200–1201.
Elie Dolgin, „Better fat bubbles could power a new generation of mRNA vaccines,” Science News, May 12, 2022, https://www.science.org/content/article/better-fat-bubbles-could-power-new-mrna-vaccines.
Elie Dolgin, „How a pioneering diabetes drug offers hope for preventing autoimmune disorders,” Nature 614, no. 7948 (February 2023): 404–6.
Elie Dolgin, „How personalized cancer vaccines could keep tumours from coming back,” Nature 630, no. 8016 (June 2024): 290–292.
Elie Dolgin, „Self-copying RNA vaccine wins first full approval: What’s next?,” Nature 624, no. 7991 (December 2023): 236–237.
Elie Dolgin, „The tangled history of mRNA vaccines,” Nature 597, no. 7876 (September 2021): 318–324.
Elif Cakan et al., „TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance,” Journal of Experimental Medicine 220, no. 12 (December 2023): e20230944.
Eliot Brinton, „Statin-related new-onset diabetes appears driven by increased insulin resistance: Are there clinical implications?,” Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 11 (November 2021): 2798–801.
Elisabeth Widén et al., „How communicating polygenic and clinical risk for atherosclerotic cardiovascular disease impacts health behavior: An observational follow-up study,” Circulation: Genomic and Precision Medicine 15, no. 2 (April 2022): e003459.
Elisa Konofagou, „Microbubble ultrasound maps hid-den signs of heart disease,” Nature News & Views, May 6, 2024, https://www.nature.com/articles/d41586-024-01194-2.
Elizabeth Cohen, „Shingles vaccine linked with lower dementia risk, study shows,” Washington Post, July 30, 2024, https://www.washingtonpost.com/wellness/2024/07/30/shingles-vaccine-lower-dementia-risk/.
Elizabeth Darby et al., „Molecular mechanisms of antibiotic resistance revisited,” Nature Reviews Microbiology 21, no. 5 (May 2023): 280–295.
Elizabeth Huynh et al., „Artificial intelligence in radiation oncology,” Nature Reviews Clinical Oncology 17, no. 12 (December 2020): 771–781.
Elizabeth Park et al., „Targeting the gut and tumor microbiota in cancer,” Nature Medicine 28, no. 4 (April 2022): 690–703.
Ellen Apperloo et al., „Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: A smart-c collaborative meta-analysis of randomised controlled trials,” Lancet Diabetes & Endocrinology 12, no. 8 (August 2024): 545–557.
Emily Anthes, „Could a drug give your pet more dog years?,” New York Times, November 29, 2023, https://www.nytimes.com/2023/11/28/science/longevity-drugs-dogs.html.
Emily Han-Chung Hsiue et al., „Targeting a neoantigen derived from a common TP53 mutation,” Science 371, no. 6533 (March 2021): eabc8697.
Emily McNally et al., „Long telomeres and cancer risk: The price of cellular immortality,” Journal of Clinical Investigation 129, no. 9 (August 2019): 3474–3481.
Emily Rogalski et al., „Youthful memory capacity in old brains: Anatomic and genetic clues from the Northwestern SuperAging Project,” Journal of Cognitive Neuroscience 25, no. 1 (January 2013): 29–36.
Emily Sims et al., „Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals,” Science Translational Medicine 13, no. 583 (March 2021): eabc8980.
Emma Derbyshire, „Could we be overlooking a potential choline crisis in the United Kingdom?,” BMJ Nutrition, Prevention & Health 2, no. 2 (August 2019): 86–89.
Emma Garnett et al., „Impact of increasing vegetarian availability on meal selection and sales in cafeterias,” Proceedings of the National Academy of Sciences of the USA 116, no. 42 (October 2019): 20923–0929.
Emmanuelle Bostock et al., „Consumer reports of ‘keto flu’ associated with the ketogenic diet,” Frontiers in Nutrition 7 (March 2020): 20.
Emmanuelle Schindler et al., „The therapeutic potential of psychedelics,” 378, no. 6624 (December 2022): 1051–1053.
Emre Sezgin et al., „Behavioral health and generative AI: A perspective on future of therapies and patient care,” NPJ Mental Health Research 3, no. 1 (June 2024): 25.
EM Tuzcu et al., „High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: Evidence from intravascular ultrasound,” Circulation 103, no. 22 (June 2001): 2705–2710.
EPILOG Investigators, „Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization,” New England Journal of Medicine 336, no. 24 (June 1997): 1689–1696.
Erica Lorenzo et al., „Impact of senolytic treatment on immunity, aging, and disease,” Frontiers in Aging 4 (October 2023): 1161799
Eric An et al., „Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions,” Nature Mental Health 2, no. 8 (August 2024): 935–950.
Eric Klopack et al., „Social stressors associated with age-related T lymphocyte per-centages in older US adults: Evidence from the US health and retirement study,” Proceedings of the National Academy of Sciences of the USA 119, no. 25 (June 2022): e2202780119.
Eric Nuermberger et al., „Restocking the tuberculosis drug arsenal,” Nature Medicine 30, no. 3 (March 2024): 642–643.
Eric Topol, „A culture of [blood] cultures,” Substack, December 17, 2022, https://erictopol.substack.com/p/a-culture-of-blood-cultures.
Eric Topol, „AI-enabled opportunistic medical scan interpretation,” Lancet 403, no. 10439 (May 11, 2024): 1842.
Eric Topol, „A new precedent—AI Gets the ‘American Nobel’ prize in medicine,” Substack, October 1, 2023, https://erictopol.substack.com/p/a-new-precedentai-gets-the-american.
Eric Topol, „Charlie Swanton: A master class on cancer,” Substack, June 14, 2024, https://erictopol.substack.com/p/charlie-swanton-a-master-class-on.
Eric Topol, „Daniel Drucker: Illuminating the GLP-1 drug’s break out,” Sub-stack, April 6, 2024, https://erictopol.substack.com/p/daniel-drucker-illuminating-the-glp.
Eric Topol, „David Liu: A master class on the future of genome editing,” Substack, December 10, 2023, https://erictopol.substack.com/p/david-liu-a-master-class-on-the-future.
Eric Topol, „Editing babies? We need to learn a lot more first,” New York Times, November 27, 2018, https://www.nytimes.com/2018/11/27/opinion/genetically-edited-babies-china.html#:~:text=Dr.,at%20the%20Scripps%20Research%20Institute.
Eric Topol, „Engineering T cells,” Substack, January 29, 2023, https://erictopol.substack.com/p/engineering-t-cells.
Eric Topol, „Euan Ashley: Exercise may be the single most potent medical intervention ever known,” Substack, July 5, 2024, https://erictopol.substack.com/p/evan-ashley-exercise-may-be-the-single.
Eric Topol, „How to upend cancer screening,” Substack, June 25, 2023, https:// erictopol.substack.com/p/how-to-upend-cancer-screening.
Eric Topol, „Medical forecasting,” Science 384, no. 6698 (May 2024): eadp7977, https://doi.org/10.1126/science.adp7977.
Eric Topol, „On genome editing with Fyodor Urnov, a pioneer,” Substack, October 12, 2023, https://erictopol.substack.com/p/on-genome-editing-with-fyodor-urnov#details.
Eric Topol, „Spatial biology is lighting it up,” Substack, July 23, 2023, https://eric topol.substack.com/p/spatial-biology-is-lighting-it-up.
Eric Topol, „The AI Diet,” New York Times, March 2, 2019, https://www.nytimes.com/2019/03/02/opinion/sunday/diet-artificial-intelligence-diabetes.html.
Eric Topol, „The big miss: Inflammation and cardiovascular disease,” Substack, June 9, 2024, https://erictopol.substack.com/p/the-big-miss-inflammation-and-cardio vascular.
Eric Topol, „The diabetes dilemma for statin users,” New York Times, March 4, 2012, https://www.nytimes.com/2012/03/05/opinion/the-diabetes-dilemma-for-statin-users.html.
Eric Topol, „The new obesity breakthrough drugs,” Substack, Decem-ber 10, 2022, https://erictopol.substack.com/p/the-new-obesity-breakthrough-drugs.
Eric Topol, „The science behind food and dangers of ultra-processed, artificial, non-food with Dr. Chris van Tulleken,” Substack, October 24, 2023, https://erictopol.substack.com/p/the-science-behind-food-and-dangers#details.
Eric Topol, „The under-appreciation of CHIP,” Substack, May 21, 2023, https://erictopol.substack.com/p/the-under-appreciation-of-chip.
Eric Topol, „Towards an optimal diet,” Substack, 2023, https://erictopol.sub stack.com/p/towards-an-optimal-diet.
Eric Topol, „Transforming medicine via digital innovation,” Science Translational Medicine 2, no. 16 (January 2010): 16cm4, https://doi.org/10.1126/scitranslmed.3000484.
Eric Topol, „When there is actionable, lifesaving genetic information,” Substack, November 18, 2023, https://erictopol.substack.com/p/when-there-is-actionable-lifesaving.
“By the age of… 73 years of age”: Sharon Plon et al., „Ten years of incidental, secondary, and actionable findings,” New England Journal of Medicine 389, no. 19 (November 2023): 1813–1814.
Eric Topol et al., „Genetic susceptibility to myocardial infarction and coronary artery disease,” Human Molecular Genetics 15, no. 2 (October 2006): R117–123.
Eric Topol et al., „Hypertensive hypertrophic cardiomyopathy of the elderly,” New England Journal of Medicine 312, no. 5 (January 1985): 277–283.
Eric Topol et al., „It takes a planet,” Nature Biotechnology 37, no. 8 (August 2019): 858–861.
Eric Topol et al., „Operation nasal vaccine-lightning speed to counter Covid-19,” Science Immunology 7, no. 74 (August 2022): eadd9947.
Eric Topol et al., „Rimonabant for prevention of cardiovascular events (CRESCENDO): A randomised, multicentre, placebo-controlled trial,” Lancet 376, no. 9740 (August 2010): 517–523.
Eric Vivier et al., „Natural killer cell therapies,” Nature 626, no. 8000 (February 2024): 727–736.
Erika Hayasaki, „Has this scientist found the fountain of youth,” MIT Technology Review, August 8, 2019, https://www.technologyreview.com/2019/08/08/65461/scientist-fountain-of-youth-epigenome/.
Erikka Loftfield et al., „Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings from the UK Biobank,” JAMA Internal Medicine 178, no. 8 (August 2018): 1086–1097.
Erik Kristoffer Arnesen et al., „Nuts and seeds consumption and risk of cardiovascular disease, type 2 diabetes and their risk factors: A systematic review and meta-analysis,” Food & Nutrition Research 67 (February 2023), https://doi.org/10.29219/fnr.v67.8961.
Erin Cohn et al., „Pervasive environmental chemicals impair oligodendrocyte development,” Nature Neuroscience 27, no. 5 (May 2024): 836–845.
Erla Bjornsdottir et al., „Association between physical activity over a 10-year period and current insomnia symptoms, sleep duration and daytime sleepiness: A European population-based study,” BMJ Open 14, no. 3 (March 2024): e067197.
Ernest Arenas, „Parkinson’s disease in the single-cell era,” Nature Neuroscience 25, no. 5 (May 2022): 536–538.
Ernest Granson, „How Parvus Therapeutics Inc. discovered a new class of drugs,” Avenue Calgary Magazine, June 9, 2021, https://www.avenuecalgary.com/innovation/parvus-therapeutics-inc-navacims/.
Esra Tasali et al., „Effect of sleep extension on objectively assessed energy intake among adults with overweight in real-life settings: A randomized clinical trial,” JAMA Internal Medicine 182, no. 4 (April 2022): 365–374.
Eugene Braunwald, „Cholesterol: The race to the bottom,” European Heart Journal 42, no. 45 (December 2021): 4612–4613.
Eunhee Kim et al., „Irisin reduces amyloid-beta by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling,” Neuron 111, no. 22 (November 2023): 3619–3633 e8.
Evangelos Konstantinidis et al., „CRISPR-Cas9 treatment partially restores amyloid-beta 42⁄40 in human fibroblasts with the Alzheimer’s disease psen 1 m146l mutation,” Molecular Therapy Nucleic Acids 28 (June 2022): 450–461.
Evan Lien et al., „Low glycaemic diets alter lipid metabolism to influence tumor growth,” Nature 599, no. 7884 (November 2021): 302–7.
Evelyn Campbell et al., „Fe, fi, fo, fum, I smell the diet of a healthy human,” Cell 184, no. 16 (August 2021): 4107–9.
Ewen Callaway, „Ex-Meta scientists debut gigantic AI protein design model,” Nature (July 2024).
Fabian Eichelmann et al., „Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03124-1.
Fabian Suchy et al., „Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors,” Nature Biotechnology (April 2024), https://doi.org/10.1038/s41587-024-02171-w.
Fabrice Andre et al., „Forget lung, breast or prostate cancer: Why tumour naming needs to change,” Nature 626, no. 7997 (February 2024): 26–29.
Fangping Wan et al., „Deep-learning-enabled antibiotic discovery through molecular de-extinction,” Nature Biomedical Engineering 8, no. 7 (July 2024): 854–871.
Farhad Islami et al., „Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019,” CA: A Cancer Journal for Clinicians (July 2024), https://doi.org/10.3322/caac.21858.
Farren Briggs, „Unraveling susceptibility to multiple sclerosis,” Science 365, no. 6460 (September 2019): 1383–1384.
FB Mensink et al., „Pharmaco-invasive therapy: Early implementation of statins and proprotein convertase subtilisin/kexin type 9 inhibitors after acute coronary syndrome,” Frontiers in Cardiovascular Medicine 9 (December 2022): 1061346.
Federica Picariello et al., „A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition,” Psychological Medicine (February 2024): 1–14.
Feipeng Cui et al., „Early-life exposure to tobacco, genetic susceptibility, and accelerated biological aging in adulthood,” Science Advances 10, no. 18 (May 2024): eadl3747.
Felice Gragnano et al., „FLOW trial stopped early due to evidence of renal protection with semaglutide,” European Heart Journal—Cardiovascular Pharmacotherapy 10, no. 1 (January 2024): 7–9.
Felix Berriat et al., „The contribution of the peripheral immune system to neurodegeneration,” Nature Neuroscience 26, no. 6 (June 2023): 942–954.
Felix Fischbach et al., „CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis,” Med 5, no. 6 (June 2024): 550–558.e2.
Felix Wong et al., „Discovering small-molecule senolytics with deep neural networks,” Nature Aging 3, no. 6 (June 2023): 734–750.
Felix Wong et al., „Discovery of a structural class of antibiotics with explainable deep learning,” Nature 626, no. 7997 (February 2024): 177–185.
Fenglei Li et al., „The liver works as a school to educate regulatory immune cells,” Cellular & Molecular Immunology 10, no. 4 (July 2013): 292–302.
Feng Ning et al., „Cardiovascular disease mortality in Europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range,” Diabetes Care 33, no. 10 (October 2010): 2211–2216.
Feng Ren et al., „A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models,” Nature Biotechnology (March 2024), https://doi.org/10.1038/s41587-024-02143-0.
Fernando Polack et al., „Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine,” New England Journal of Medicine 383, no. 27 (December 2020): 2603–2615.
Fiona Ross et al., „The interplay between diet and the gut microbiome: Implications for health and disease,” Nature Reviews Microbiology (July 2024), https://doi.org/10.1038/s41579-024-01068-4.
Florent Ginhoux et al., „Single-cell immunology: Past, present, and future,” Immunity 55, no. 3 (March 2022): 393–404.
Florentina Porsch et al., „Autoimmune diseases and atherosclerotic cardiovascular disease,” Nature Reviews Cardiology (June 2024), https://doi.org/10.1038/s41569-024-01045-7.
Floris Fransen et al., „Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice,” Frontiers in Immunology 8 (November 2017): 1385.
Fraiser Kansteiner, „A pharmaceutical jack of all trades? Novo CEO touts semaglutide’s potential in NASH, Alzheimer’s and its hot start in obesity,” FiercePharma, August 29, 2022, https://www.fiercepharma.com/pharma/once-and-future-glp-1-king-novo-nordisk-ceo-talks-wegovy-manufacturing-and-alzheimers.
Francesco Asnicar et al., „Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals,” Nature Medicine 27, no. 2 (February 2021): 321– 32.
Francesco Cappuccio et al., „Sleep duration and all-cause mortality: A systematic re-view and meta-analysis of prospective studies,” Sleep 33, no. 5 (May 2010): 585–592.
Francesco Rubino et al., „Joint international consensus statement for ending stigma of obesity,” Nature Medicine 26, no. 4 (April 2020): 485–497.
Francesc Villarroya et al., „Controlling brown adipose tissue size through EPAC1,” Nature Reviews Endocrinology 20, no. 5 (May 2024): 259–260.
Francine Grodstein et al., „Long-term multivitamin supplementation and cognitive function in men: A randomized trial,” Annals of Internal Medicine 159, no. 12 (December 2013): 806–814.
Francisco De La Vega et al., „Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases,” Genome Medicine 13, no. 1 (October 2021): 153.
Francis Collins, „We are squandering one of the most important medical advances of the 21st century,” New York Times, November 28, 2023, https://www.nytimes.com/2023/11/28/opinion/hepatitis-c-eliminate.html?smtyp=cur&smid=tw-nytopinion.
Francisco Lopera et al., „Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man,” Nature Medicine 29, no. 5 (May 2023): 1243–1252.
Frank Hu et al., „Can plant-based meat alternatives be part of a healthy and sustainable diet?,” JAMA 322, no. 16 (October 2019): 1547–1548.
Frank Lin et al., „Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (achieve): A multicentre, randomised controlled trial,” Lancet 402, no. 10404 (September 2023): 786–797.
Franklin Nobrega et al., „Targeting mechanisms of tailed bacteriophages,” Nature Reviews Microbiology 16, no. 12 (December 2018): 760–773.
Frank Qian et al., „Association between plant-based dietary patterns and risk of type 2 diabetes: A systematic review and meta-analysis,” JAMA Internal Medicine 179, no. 10 (October 2019): 1335–1344.
Franz Messerli et al., „Sodium intake, life expectancy, and all-cause mortality,” European Heart Journal 42, no. 21 (June 2021): 2103–2112.
Franz Messerli et al., „Sodium intake, life expectancy, and all-cause mortality,” European Heart Journal 42, no. 21 (June 2021): 2103–2112.
Fred Tabung et al., „Association of dietary inflammatory potential with colorectal cancer risk in men and women,” JAMA Oncology 4, no. 3 (March 2018): 366–373.
Fu-Shun Yen et al., „Glucagon-like peptide-1 receptor agonists and risk of sight-threatening retinopathy in Taiwanese population: A propensity based cohort study,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews 18, no. 8 (August 2024): 103099.
Fydor Urnov, „The power and potential of gene tuning,” TIME, August 12, 2024, https://time.com/7009555/gene-tuning-power-essay/.
Fyodor Urnov, „We can cure disease by editing a person’s DNA. Why aren’t we?,” New York Times, December 9, 2022, https://www.nytimes.com/2022/12/09/opinion/crispr-gene-editing-cures.html.
G. López-Cantillo et al., „CAR-T cell performance: How to improve their persistence?,” Frontiers in Immunology 13 (2022): 878209.
Gabriel Baldanzi et al., „Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS,” EBioMedicine 100 (February 2024): 104989.
Gabriel Marx et al., „Histopathologic brain age estimation via multiple instance learning,” Acta Neuropathologica 146, no. 6 (December 2023): 785–802.
Gaia Vetere et al., „The relationship between playing musical instruments and cognitive trajectories: Analysis from a UK ageing cohort,” International Journal of Geriatric Psychiatry 39, no. 2 (February 2024): e6061.
Gal Tsaban et al., „The effect of green Mediterranean diet on cardio-metabolic risk; a randomised controlled trial,” Heart 107, no. 13 (June 2021): 1054–1061.
Gang Jin et al., „A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice,” Nature Immunology 25, no. 6 (May 2024): 1059–1072.
Ganqiang Liu et al., „Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease,” Nature Genetics 53, no. 6 (June 2021): 787–793.
Gaspard Kerner et al., „Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-neolithic Europe,” Cell Genomics 3, no. 2 (February 2023): 100248.
GBD Alcohol Collaborators, „Population-level risks of alcohol consumption by amount, geography, age, sex, and year: A systematic analysis for the global burden of disease study 2020,” Lancet 400, no. 10347 (July 2022): 185–235.
GBD Diet Collaborators, „Health effects of dietary risks in 195 countries, 1990–2017: A systematic analysis for the global burden of disease study 2017,” Lancet 393, no. 10184 (May 2019): 1958–1972.
GBD Risk Factors Collaborators, „Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: A systematic analysis for the global burden of disease study 2021,” Lancet 403, no. 10440 (May 2024): 2162–203.
Ge Chen et al., „Regular use of fish oil supplements and course of cardiovascular diseases: Prospective cohort study,” MBJ Medicine 3, no. 1 (May 2024): e000451.
Gen Li et al., „Transformer-based AI technology improves early ovarian cancer diagnosis using cfDNA methylation markers,” Cell Reports Medicine (July 2024): 101666.
Gennaro Pagano et al., „Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease,” Nature Medicine 30, no. 4 (April 2024): 1096–103.
Genomes Project Pilot Investigators, „100,000 genomes pilot on rare-disease diagnosis in health care—preliminary report,” New England Journal of Medicine 385, no. 20 (November 2021): 1868–1880.
Geoffrey Carr, „Some claim human lifespans can be lengthened indefinitely,” Economist, September 25, 2023, https://www.economist.com/technology-quarterly/2023/09/25/some-claim-human-lifespans-can-be-lengthened-indefinitely.
George J. Xu et al., „Comprehensive serological profiling of human populations using a synthetic human virome,” Science 348, no. 6239 (June 2015): aaa0698.
George Johnson, „Why everyone seems to have cancer,” New York Times, January 4, 2014, https://www.nytimes.com/2014/01/05/sunday-review/why-everyone-seems-to-have-can cer.html?pagewanted=print.
Georg Schett et al., „CAR T-cell therapy in autoimmune diseases,” Lancet 402, no. 10416 (November 2023): 2034–2044.
Gholami Fatemeh et al., „Effect of melatonin supplementation on sleep quality: A systematic review and meta-analysis of randomized controlled trials,” Journal of Neurology 269, no. 1 (January 2022): 205–216.
Giacomo Koch et al., „Precuneus magnetic stimulation for Alzheimer’s disease: A randomized, sham-controlled trial,” Brain 145, no. 11 (November 2022): 3776–3786.
Giang Nguyen et al., „A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells,” Nature Biotechnology 39, no. 1 (January 2021): 47–55.
Gillian Dohrn, „Gut microbes linked to fatty diet drive tumour growth,” Nature News, May 16, 2024, https://www.nature.com/articles/d41586-024-01443-4.
Gill Livingston et al., „Dementia prevention, intervention, and care: 2024 report of the lancet standing commission,” Lancet 404, no. 10452 (August 2024): 572–628.
Gina Kolata, „Cancer deaths are falling, but there may be an asterisk,” New York Times, January 17, 2024, https://www.nytimes.com/2024/01/17/health/cancer-deaths-decline.html.
Gina Kolata, „Study puts a $43 billion yearly price tag on cancer screening,” New York Times, August 5, 2024, https://www.nytimes.com/2024/08/05/health/cancer-screening-tests-cost.html.
Gina Kolata et al., „Advisory panel of experts endorses F.D.A. approval of new Alzheimer’s drug,” New York Times, June 10, 2024, https://www.nytimes.com/2024/06/10/health/alzheimers-treatment-donanemab.html.
Gina Many et al., „Sexual dimorphism and the multiomic response to exercise training in rat subcutaneous white adipose tissue,” Nature Metabolism 6, no. 5 (May 2024): 963–979.
Giorgia Guglielmi, „Found: The dial in the brain that controls the immune system,” Nature (May 2024), https://doi.org/10.1038/d41586-024-01259-2.
Giulia Castellani et al., „Transforming the understanding of brain immunity,” Science 380, no. 6640 (April 2023): eabo7649.
Giuseppe Faraco et al., „Dietary salt promotes cognitive impairment through tau phosphorylation,” Nature 574, no. 7780 (October 2019): 686–690.
Giuseppe Faraco et al., „Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response,” Nature Neuroscience 21, no. 2 (February 2018): 240–249.
Giuseppe Grosso et al., „Coffee, caffeine, and health outcomes: An umbrella review,” Annual Review of Nutrition 37 (August 2017): 131–156.
Giuseppe Matarese, „The link between obesity and autoimmunity,” Science 379, no. 6639 (March 2023): 1298–300.
Gone with the Century?”: MS Brown et al., „Heart attacks: Gone with the century?,” Science 272, no. 5262 (May 1996): 629.
Goro Katsuumi et al., „SGLT2 inhibition eliminates senescent cells and alleviates pathological aging,” Nature Aging (May 2024).
Grace Christensen et al., „Association of PM(2.5) exposure and Alzheimer disease pathology in brain bank donors—effect modification by APOE genotype,” Neurology 102, no. 5 (March 2024): e209162.
Graham Hatfull et al., „Bacteriophages and their genomes,” Current Opinion in Virology 1, no. 4 (October 2011): 298–303.
Graham Lawton, „New anti-ageing vaccines promise to prevent diseases like Alzheimer’s,” New Scientist, July 3, 2024, https://www.newscientist.com/article/mg26334982-800-new-anti-ageing-vaccines-promise-to-prevent-diseases-like-alzheimers/.
Grant Brown et al., „TLR7 gain-of-function genetic variation causes human lupus,” Nature 605, no. 7909 (May 2022): 349–356.
Gregor Bieri et al., „Blood-to-brain communication in aging and rejuvenation,” Nature Neuroscience 26, no. 3 (March 2023): 379–393.
Gregory Bratman et al., „Nature and human well-being: The olfactory pathway,” Science Advances 10, no. 20 (2024): eadn3028.
Gregory Fahy et al., „Reversal of epigenetic aging and immunosenescent trends in humans,” Aging Cell 18, no. 6 (December 2019): e13028.
Gregory Guzauskas et al., „Population genomic screening for three common hereditary conditions: A cost-effectiveness analysis,” Annals of Internal Medicine 176, no. 5 (May 2023): 585–595.
Gregory Hannum et al., „Genome-wide methylation profiles reveal quantitative views of human aging rates,” Molecular Cell 49, no. 2 (January 2013): 359–367.
Gregory Marcus et al., „Acute effects of coffee consumption on health among ambulatory adults,” New England Journal of Medicine 388, no. 12 (March 2023): 1092–100.
Gregory Newby et al., „Base editing of haematopoietic stem cells rescues sickle cell disease in mice,” Nature 595, no. 7866 (July 2021): 295–302.
Gretchen Reynolds et al., „Are you fit for your age? Try our fitness tuneup to find out,” Washington Post, January 1, 2024, https://www.washingtonpost.com/wellness/interactive/2024/fitness-test-by-age-exercise/?
GS Mintz et al., „Atherosclerosis in angiographically ‘normal’ coronary artery reference segments: An intravascular ultrasound study with clinical correlations,” Journal of the American College of Cardiology 25, no. 7 (June 1995): 1479–1485.
Guanqiao Li et al., „The contributions of risk factors on health adjusted life expectancy (HALE) changes from 1990 to 2017: A serial cross-sectional analysis from the GBD study,” Global Transitions 4, (2022): 90–99.
Guan Wang et al., „Chemical-induced epigenome resetting for regeneration program activation in human cells,” Cell Reports 42, no. 6 (June 27, 2023): 112547.
Gulistan Agirman et al., „Signaling inflammation across the gut-brain axis,” Science 374, no. 6571 (November 2021): 1087–1092.
Gunter Hoglinger et al., „A biological classification of Parkinson’s disease: The SynNeurGe research diagnostic criteria,” Lancet Neurology 23, no. 2 (February 2024): 191–204.
GUSTO Investigators, „An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction,” New England Journal of Medicine 329, no. 10 (September 1993): 673–682.
H. Holden Thorp, „Music and the mind,” Science 383, no. 6689 (March 2024): 1271.
H. van Praag et al., „Running enhances neurogenesis, learning, and long-term potentiation in mice,” Proceedings of the National Academy of Sciences of the USA 96, no. 23 (November 1999): 13427–3431.
H. Yamanaka et al., „A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: A PET study with macaques,” Translational Psychiatry 4, no. 1 (January 2014): e342.
Hadil Zureigat et al., „Effect of stress-related neural pathways on the cardiovascular benefit of physical activity,” Journal of the American College of Cardiology 83, no. 16 (April 2024): 1543–1553.
Haiming Chen et al., „Circulating microbiome DNA as biomarkers for early diagnosis and recurrence of lung cancer,” Cell Reports Medicine 5, no. 4 (April 2024): 101499.
Hamideh Parhiz et al., „mRNA-based therapeutics: Looking beyond Covid-19 vaccines,” Lancet 403, no. 10432 (March 2024): 1192–204.
Hamilton Se-Hwee Oh et al., „Organ aging signatures in the plasma proteome track health and disease,” Nature 624, no. 7990 (December 2023): 164–172.
Hana Farnezi et al., „Three-parent babies: Mitochondrial replacement therapies,” JBRA Assisted Reproduction 24, no. 2 (May 2020): 189–196.
Handan Melike Donertas et al., „Common genetic associations between age-related diseases,” Nature Aging 1, no. 4 (April 2021): 400–412.
Han Li et al., „Systematic review and meta-analysis of AI-based conversational agents for promoting mental health and well-being,” NPJ Digital Medicine 6, no. 1 (December 2023): 236.
Hannah Davis et al., „Long Covid: Major findings, mechanisms and recommendations,” Nature Reviews Microbiology 21, no. 3 (March 2023): 133–146.
Hannah Greenwood et al., „Long-term effect of salt substitution for cardiovascular outcomes: A systematic review and meta-analysis,” Annals of Internal Medicine 177, no. 5 (May 2024): 643–655.
Hannah Hampton et al., „The arms race between bacteria and their phage foes,” Nature 577, no. 7790 (January 2020): 327–336.
Hannes Vietzen et al., „Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis,” Cell 186, no. 26 (December 2023): 5705–5718 e13.
Hany Abed et al., „Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation: A randomized clinical trial,” Journal of the American Medical Association 310, no. 19 (2013): 2050–2060.
Hanzhang Xie et al., „Association between sugar-sweetened beverages and pure fruit juice with risk of six cardiovascular diseases: A Mendelian randomization study,” European Journal of Clinical Nutrition (April 2024).
Haobo Bai et al., „Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis,” Science Translational Medicine 16, no. 732 (January 2024): eadi3275.
Hao Chang et al., „Stress-sensitive neural circuits change the gut microbiome via duodenal glands,” Cell (August 2024).
Hao Jin et al., „A body–brain circuit that regulates body inflammatory responses,” Nature 630, no. 8017 (June 2024): 695–703.
Hao Ma et al., „Food insecurity and premature mortality and life expectancy in the US,” JAMA Internal Medicine 184, no. 3 (January 2024), 301–310.
Haopeng Wang et al., „Tonicing emissions and compatibility to turbocharge CAR-T,” Nature Metabolism 6, no. 6 (June 2024): 990–992.
Haoyi Wang et al., „Gene-edited babies: What went wrong and what could go wrong,” PLoS Biology 17, no. 4 (April 2019): e3000224.
Harini Bagavant et al., „Immune response to enterococcus gallinarum in lupus patients is associated with a subset of lupus-associated autoantibodies,” Fron-tiers in Immunology 12 (May 2021): 635072.
Harrison Ball et al., „Cancer cells spread aggressively during sleep,” Nature 607, no. 7917 (July 2022): 33–34.
Harry Stevens, „Mapping America’s access to nature, neighborhood by neighborhood,” Washington Post, April 10, 2024, https://www.washingtonpost.com/climate-environment/interactive/2024/nature-health-maps-neighborhood-city/.
Haydar Frangoul et al., „CRISPR-cas9 gene editing for sickle cell disease and beta-thalassemia,” New England Journal of Medicine 384, no. 3 (January 21, 2021): 252–260.
Hayley Shanks et al., „p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: A randomized, placebo-controlled Phase 2a trial,” Nature Medicine 30, no. 6 (June 2024): 1761–1770.
Heather Galipeau et al., „Protection from inflammatory bowel disease,” Science 381, no. 6663 (September 2023): 1153–1154.
He Chen et al., „Contribution of specific diseases and injuries to changes in health adjusted life expectancy in 187 countries from 1990 to 2013: Retrospective observational study,” BMJ 364 (March 2019): l969.
Hector Mendez-Gomez et al., „RNA aggregates harness the danger response for potent cancer immunotherapy,” Cell 187, no. 10 (May 2024): 2521–2535.e21.
Heidi Ledford, „Cancer-fighting CAR T cells could be made inside body with viral injection,” Nature 625, no. 7994 (January 2024): 225–226.
Heidi Ledford, „Cancer trial results show power of weaponized antibodies,” November 2, 2023, https://www.nature.com/articles/d41586-023-03421-8.
Heidi Ledford, „CRISPR 2.0: A new wave of gene editors heads for clinical trials,” Nature 624, no. 7991 (December 2023): 234–235.
Heidi Ledford, „Gene therapy’s comeback: How scientists are trying to make it safer,” Nature 606, no. 7914 (June 2022): 443–444.
Heidi Ledford, „How air pollution causes lung cancer – without harming DNA,” Nature 616, no. 7957 (April 2023): 419–420.
Heidi Ledford, „Super-precise CRISPR tool enters US clinical trials for the first time,” Nature 621, no. 7980 (September 2023): 667–668.
Heidi Ledford, „Tumour mutations harnessed to build cancer vaccine,” Nature (April 2015), https://doi.org/10.1038/nature.2015.17250.
Heidi Ledford, „Why are so many young people getting cancer? What the data say,” Nature 627, no. 8003 (March 2024): 258–260.
Heike Tost et al., „Neural correlates of individual differences in affective benefit of real-life urban green space exposure,” Nature Neuroscience 22, no. 9 (September 2019): 1389–1393.
Hei Wan Mak et al., „Hobby engagement and mental wellbeing among people aged 65 years and older in 16 countries,” Nature Medicine 29, no. 9 (September 2023): 2233–2240.
Helen Pearson, „The rise of eco-anxiety: Scientists wake up to the mental-health toll of climate change,” Nature 628, no. 8007 (April 2024): 256–258.
Hilary Longhurst et al., „CRISPR-Cas9 in vivo gene editing of KLKB1 for hereditary angioedema,” New England Journal of Medicine 390, no. 5 (February 2024): 432–441.
Hilary Robbins, „Multicancer early detection tests—keeping a high bar for evidence of benefit,” New England Journal of Medicine 391, no. 4 (2024): 292–294.
Hilary Wall et al., „Vital signs: Prevalence of key cardiovascular disease risk factors for million hearts 2022—United States, 2011–2016,” CDC, September 7, 2018, https://www.cdc.gov/mmwr/volumes/67/wr/mm6735a4.htm?s_cid=mm6735a4_w.
H Li et al., „Association of healthy sleep patterns with risk of mortality and life expectancy at age of 30 years: A population-based cohort study,” QJM: An International Journal of Medicine 117, no. 3 (2023): 177–186.
HM Blevins et al., „The NLRP3 inflammasome pathway: A review of mechanisms and inhibitors for the treatment of inflammatory diseases,” Frontiers in Aging Neuroscience 14 (2022): 879021.
HM Connolly et al., „Valvular heart disease associated with fenfluramine-phentermine,” New England Journal of Medicine 337, no. 9 (August 1997): 581–588.
Holli Loomans-Kropp, „Multi-cancer early detection tests: A strategy for improvement,” BMJ Oncology 3, no. 1 (2024): e000184.
Hong-Bo Zhao et al., „Hearing loss promotes Alzheimer’s disease,” Nature Aging 4, no. 4 (April 2024): 443–444.
Hong-Gyun Lee et al., „Neuroinflammation: An astrocyte perspective,” Science Translational Medicine 15, no. 721 (November 2023): eadi7828.
Hong Li et al., „Global, regional, and national burden of disease study of atrial fibrillation/flutter, 1990–2019: Results from a global burden of disease study, 2019,” BMC Public Health 22, no. 1 (2022): 2015.
Hongli Jiao et al., „GATA6 regulates aging of human mesenchymal stem/ stromal cells,” Stem Cells 39, no. 1 (January 2021): 62–77.
Hong Seok Shim et al., „TERT activation targets DNA methylation and multiple aging hallmarks,” Cell 187, no. 15 (July 2024): 4030–4042.e13.
Hongwei Ji et al., „Sex differences in association of physical activity with all-cause and cardiovascular mortality,” Journal of the American College of Cardiology 83, no. 8 (February 2024): 783–793.
Hongying Shi et al., „Sedentary behaviors, light-intensity physical activity, and healthy aging,” JAMA Network Open 7, no. 6 (2024): e2416300-e00.
Hongyi Zhang et al., „Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution,” Cancer Cell 41, no. 10 (October 2023): 1788–802 e10.
Hsin-Kai Liao et al., „In vivo target gene activation via CRISPR/cas9-mediated trans-epigenetic modulation,” Cell 171, no. 7 (December 2017): 1495–507 e15.
Hubert Kolb et al., „Health effects of coffee: Mechanism unraveled?,” Nutrients 12, no. 6 (June 2020).
Huda Akil et al., „The neurobiology of stress: Vulnerability, resilience, and major depression,” Proceedings of the National Academy of Sciences of the USA 120, no. 49 (December 2023): e2312662120.
Huige Tong et al., „Quantifying the stochastic component of epi-genetic aging,” Nature Aging 4, no. 6 (May 2024): 886–901.
Huilin Tang et al., „Association of glucagon-like peptide 1 receptor agonists with incident Parkinson’s disease in U.S. older adults with type 2 diabetes,” Diabetes 73, no. Supplement_1 (June 2024).
Huize Pan et al., „Atherosclerosis is a smooth muscle cell-driven tumor-like disease,” Circulation 149, no. 24 (2024): 1885–1898.
Humaira Jamshed et al., „Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity: A randomized clinical trial,” JAMA Internal Medicine 182, no. 9 (September 2022): 953–962.
Hye-Jung Kim et al., „Regulatory T cells subdue an autoimmune disease,” Nature 572, no. 7770 (August 2019): 443–445.
Hyun-Kyoung Kim, „The effects of artificial intelligence chatbots on women’s health: A systematic review and meta-analysis,” Healthcare (Basel) 12, no. 5 (February 2024): 534.
Hyuna Sung et al., „Differences in cancer rates among adults born between 1920 and 1990 in the USA: An analysis of population-based cancer registry data,” Lancet Public Health 9, no. 8 (August 2024): e583–e93.
I-Min Lee et al., „Association of step volume and intensity with all-cause mortality in older women,” JAMA Internal Medicine 179, no. 8 (August 2019): 1105–1112.
Ian Hatton et al., „The human cell count and size distribution,” Proceedings of the National Academy of Sciences of the USA 120, no. 39 (September 2023): e2303077120.
Ian Thompson et al., „The influence of finasteride on the development of prostate cancer,” New England Journal of Medicine 349, no. 3 (July 2003): 215–224.
Iciar Aviles-Olmos et al., „Exenatide and the treatment of patients with Parkinson’s disease,” Journal of Clinical Investigation 123, no. 6 (June 2013): 2730–2736.
IHME-CHAIN Collaborators, „Effects of education on adult mortality: A global systematic review and meta-analysis,” Lancet Public Health 9, no. 3 (March 2024): e155–e65.
Ingrid Toews et al., „Association between intake of non-sugar sweeteners and health outcomes: Systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies,” British Medical Journal 364 (January 2019): k4718.
Ingrid Williams, „Can AI-driven voice analysis help identify mental disorders?,” New York Times, April 5, 2022, https://www.nytimes.com/2022/04/05/technology/ai-voice-analysis-mental-health.html?mc_cid=1ab39c4971&mc_eid=481136448f.
Intae Moon et al., „Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary,” Nature Medicine 29, no. 8 (August 2023): 2057–2067.
Richard Chen et al., „Pan-cancer integrative histology-genomic analysis via multimodal deep learning,” Cancer Cell 40, no. 8 (August 2022): 865–878 e6.
International Monetary Fund, Communications Department, „Picture this: The journey of the Covid-19 vaccine,” Finance & Development 58, no. 4 (December 2021): A012.
Irene Martinez-Morata et al., „Association of urinary metals with cardiovascular dis-ease incidence and all-cause mortality in the multi-ethnic study of atherosclerosis (MESA),” Circulation 150, no. 10 (August 2024), https://doi.org/doi:10.1161/CIRCULATIONAHA.124.069414.
Irina Conboy et al., „Rejuvenation of aged progenitor cells by exposure to a young systemic environment,” Nature 433, no. 7027 (February 2005): 760–764.
Iruka Okeke et al., „The scope of the antimicrobial resistance challenge,” Lancet 403, no. 10442 (June 2024): 2426–2438.
Isaac Moshe et al., „Digital interventions for the treatment of de-pression: A meta-analytic review,” Psychological Bulletin 147, no. 8 (August 2021): 749–786.
Isabel Iguacel et al., „Vegetarianism and veganism compared with mental health and cognitive outcomes: A systematic review and meta-analysis,” Nutrition Reviews 79, no. 4 (March 2021): 361–381.
it’s never too late: Lorcan Daly et al., „Physiological characteristics of a 92-yr-old four-time world champion indoor rower,” Journal of Applied Physiology 135, no. 6 (December 2023): 1415–1420.
J. Graham Ruby et al., „Estimates of the heritability of human longevity are substantially inflated due to assortative mating,” Genetics 210, no. 3 (November 2018): 1109–1124.
J. Kellogg Parsons et al., „Effect of a behavioral intervention to increase vegetable consumption on cancer progression among men with early-stage prostate cancer: The meal randomized clinical trial,” Journal of the American Medical Association 323, no. 2 (January 2020): 140–148.
J. Liu et al., „Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and with-out diabetes or previous stroke: An open-label, blinded-outcome, randomised trial,” Lancet 404, no. 10449 (July 2024): 245–255.
J. Michael Gaziano et al., „Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (arrive): A randomised, double-blind, placebo-controlled trial,” Lancet 392, no. 10152 (September 2018): 1036–1046.
Jacob Gersen, „If we are what we eat, we don’t know who we are,” New York Times, July 7, 2023, https://www.nytimes.com/2023/07/07/books/review/ultra-processed-people-chris-van-tulleken.html.
Jacqueline Lane et al., „Genetics of circadian rhythms and sleep in human health and disease,” Nature Reviews Genetics 24, no. 1 (January 2023): 4–20.
Jaeu Yi et al., „Antigen-specific depletion of CD4(+) T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity,” Science Immunology 7, no. 76 (October 2022): eabo0777.
JA Hardy et al., „Alzheimer’s disease: The amyloid cascade hypothesis,” Science 256, no. 5054 (April 1992): 184–185.
Jaime Guevara-Aguirre et al., „Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency,” Med S2666-6340, no. 24 (April 2024): 00134-X.
Jaime Restrepo et al., „Ten-year follow-up of 9-valent human papilloma-virus vaccine: Immunogenicity, effectiveness, and safety,” Pediatrics 152, no. 4 (October 2023): e2022060993.
Jakob Riedl et al., „Molecular diagnostics tailoring personalized cancer therapy-an oncologist’s view,” Virchows Archive 484, no. 2 (February 2024): 169–179.
Jakob Weiss et al., „Deep learning to estimate cardiovascular risk from chest radiographs: A risk prediction study,” Annals of Internal Medicine 177, no. 4 (April 2024): 409–417.
James Fries, „The compression of morbidity,” Annals of the Academy of Medicine of Singapore 12, no. 3 (July 1983): 358–367.
James Nelson et al., „Engineered pegrnas improve prime editing efficiency,” Nature Biotechnology 40, no. 3 (March 2022): 402–410.
James Parkinson, „An essay on the shaking palsy. 1817,” Journal of Neuropsychiatry and Clinical Neurosciences 14, no. 2 (Spring 2002): 223–236; discussion 22, https:// doi.org/10.1176/jnp.14.2.223.
Jamie Brett et al., „Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1,” Nature Metabolism 2, no. 4 (April 2020): 307–317.
Jamie Edwards et al., „Exercise training and resting blood pressure: A large-scale pairwise and network meta-analysis of randomised controlled trials,” British Journal of Sports Medicine 57, no. 20 (October 2023): 1317–1326.
Jamie Justice et al., „Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study,” EBioMedicine 40 (February 2019): 554–563.
Jane Huang et al., „Autonomous artificial intelligence for diabetic eye disease increases access and health equity in underserved populations,” NPJ Digital Medicine 7, no. 1 (July 2024): 196.
Janet Siliciano et al., „HIV cure: The daunting scale of the problem,” Science 383, no. 6684 (February 2024): 703–5.
Jan Vijg et al., „Pathogenic mechanisms of somatic mutation and genome mosaicism in aging,” Cell 182, no. 1 (July 2020): 12–23.
Jan Witowski et al., „Improving breast cancer diagnostics with deep learning for MRI,” Science Translational Medicine 14, no. 664 (September 2022): eabo4802.
Jaroslav Zak et al., „JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma,” Science 384, no. 6702 (June 2024): eade8520.
Jasmine Mah et al., „Oral magnesium supplementation for insomnia in older adults: A systematic review & meta-analysis,” BMC Complementary Medicine and Therapies 21, no. 1 (April 2021): 125.
Jason Gill, „Linking volume and intensity of physical activity to mortality,” Nature Medicine 26, no. 9 (September 2020): 1332–1334.
Jason Mast, „A faster, simpler, cheaper cancer cell therapy is about to be tested in humans,” STAT News, July 9, 2024, https://www.statnews.com/2024/07/09/interius-in-vivo-car-t-cancer/.
Jason Mast, „Trying to outrun her prion disease, researcher creates powerful epigenetic editor in mice,” STAT News, June 27, 2024, https://www.statnews.com/2024/06/27/prion-disease-sonia-vallabh-epigenetic-editor-crispr/.
Jason Mast, „Why the world’s most expensive drug might not be all that over-priced,” STAT News, March 28, 2024, https://www.statnews.com/2024/03/28/gene-therapy-mld-lenmeldy-orchard-price/.
Jason Mast et al., „CRISPR patent fight redux? A new battle is brewing among biotechs over next-gen gene-editing tools,” STAT News, March 1, 2023, https://www.statnews.com/2023/03/01/gene-editing-tools-next-generation-crispr-biotechs-battle/.
Jason McLellan et al., „Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus,” Science 342, no. 6158 (November 2013): 592–598.
Jason Ross et al., „Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity,” Nature 628, no. 8006 (April 2024): 162–170.
Jasper Most et al., „Calorie restriction in humans: An update,” Ageing Research Reviews 39 (October 2017): 36–45.
Javed Butler et al., „Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: A pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials,” Lancet 403, no. 10437 (April 2024): 1635–1648.
Javier Delgado-Lista et al., „Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (cordioprev): A randomised controlled trial,” Lancet 399, no. 10338 (May 2022): 1876–1885.
Javier Fernandez-Mateos et al., „Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer,” Nature Cancer (July 2024), https://doi.org/10.1038/s43018-024-00787-0.
Jay Pandit et al., „Smartphone apps in the Covid-19 pandemic,” Nature Biotechnology 40, no. 7 (July 2022): 1013–1022.
J Diana Zhang et al., „Interpretable machine learning on metabolomics data reveals biomarkers for Parkinson’s disease,” ACS Central Science 9, no. 5 (May 2023): 1035–1045.
Jean-Paul Pirnay et al., „Personalized bacteriophage therapy outcomes for 100 consecutive cases: A multicentre, multinational, retrospective observational study,” Nature Microbiology 9, no. 6 (June 2024): 1434–1453.
Jean-Philippe Collet et al., „Long-term evolution of premature coronary artery disease,” Journal of the American College of Cardiology 74, no. 15 (October 2019): 1868–1878.
Jeffrey Bluestone et al., „Immunotherapy: Building a bridge to a cure for type 1 diabetes,” Science 373, no. 6554 (July 2021): 510–516.
Jeffrey Mason et al., „Transplantation of young ovaries to old mice in-creased life span in transplant recipients,” Journals of Gerontology Series A: Biological Sciences and Medical Sciences 64, no. 12 (December 2009): 1207–1211.
Jeffrey Schweitzer et al., „Personalized iPSC-derived dopamine progenitor cells for Parkinson’s disease,” New England Journal of Medicine 382, no. 20 (May 2020): 1926–1932.
Jeffrey Weber et al., „Individualised neoantigen therapy mRNA-4157 (v940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (keynote-942): A randomised, Phase 2b study,” Lancet 403, no. 10427 (February 2024): 632–644.
Jeff Sevigny et al., „The antibody aducanumab reduces beta plaques in Alzheimer’s disease,” Nature 537, no. 7618 (September 2016): 50–56.
Jenna Turocy et al., „Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice,” Cell 184, no. 6 (March 2021): 1561–1574.
Jennifer Abbasi et al., „One day, AI could mean better mental health for all,” JAMA 331, no. 20 (2024): 1691–1694.
Jennifer Caswell-Jin et al., „Analysis of breast cancer mortality in the US – 1975 to 2019,” JAMA 331, no. 3 (January 2024): 233–241.
Jennifer Couzin-Frankel, „Can infections cause Alzheimer’s? A small community of researchers is determined to find out,” Science Insider, July 30, 2024, https://www.science.org/content/article/can-infections-cause-alzheimer-s-small-community-researchers-determined-find-out#:~:text=The%20COVID%2D19%20pandemic%20lent,protein%20of%20 Alzheimer’s%20called%20tau.
Jennifer Couzin-Frankel, „Her work paved the way for blockbuster obesity drugs. Now, she’s fighting for recognition,” Science News, September 8, 2023, https://www.science.org/content/article/her-work-paved-way-blockbuster-obesity-drugs-now-she-s-fighting-recognition.
Jennifer Couzin-Frankel, „Why are elite athletes prone to abnormal heart rhythms?,” May 14, 2024, https://www.science.org/content/article/why-are-elite-athletes-prone-abnormal-heart-rhythms.
Jennifer Doudna, „The promise and challenge of therapeutic genome editing,” Nature 578, no. 7794 (February 2020): 229–236.
Jennifer Kahn, „CRISPR pioneer Jennifer Doudna has the guts to take on the microbiome,” Wired, September 19, 2023, https://www.wired.com/story/crispr-jennifer-doudna-microbiome/.
Jennifer Michaelson et al., „CD19-directed T cell–engaging antibodies for the treatment of autoimmune disease,” Journal of Experimental Medicine 221, no. 5 (2024).
Jennifer Rood et al., „Impact of the human cell atlas on medicine,” Nature Medicine 28, no. 12 (December 2022): 2486–2496.
Jenny Guadamuz et al., „Global, regional and national trends in statin utilisation in high-income and low/middle-income countries, 2015-2020,” BMJ Open 12, no. 9 (September 2022): e061350.
Jenny Hällqvist et al., „Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset,” Nature Communications 15, no. 1 (June 2024): 4759.
Jeremy Puthumana et al., „Speed, evidence, and safety characteristics of vaccine approvals by the US Food and Drug Administration,” JAMA Internal Medicine 181, no. 4 (April 2021): 559–560.
Jesse Poganik et al., „Biological age is increased by stress and restored upon recovery,” Cell Metabolism 35, no. 5 (May 2023): 807–820 e5.
Jessica Evert et al., „Morbidity profiles of centenarians: Survivors, de-layers, and escapers,” Journals of Gerontology, Series A: Biological Sciences & Medical Sciences 58, no. 3 (March 2003): 232–237.
Jessica Hamzelou, „This company plans to transplant gene-edited pig hearts into babies next year,” Technology Review, July 17, 2023, https://www.technologyreview.com/2023/07/17/1076392/this-company-plans-to-transplant-pig-hearts-into-babies-next-year/.
Jessica Lavery et al., „Association of exercise with pan-cancer incidence and overall survival,” Cancer Cell 42, no. 2 (February 2024): 169–171, https://doi.org/10.1016/j.ccell.2023.12.007.
Jethro Kwong et al., „Integrating artificial intelligence into healthcare systems: More than just the algorithm,” NPJ Digital Medicine 7, no. 1 (March 2024): 52.
Jianing Wang et al., „Long-term exposure to residential greenness and decreased risk of depression and anxiety,” Nature Mental Health 2 (March 2024): 525–534.
Jian Sheng Loh et al., „Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases,” Signal Transduction and Targeted Therapy 9, no. 1 (February 2024): 37.
Jiansong Fang et al., „Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease,” Nature Aging 1, no. 12 (December 2021): 1175–1188.
Jiaqi Liu et al., „ ‘Boosting’ tumor immunity in elderly mice by hyperactivating dendritic cells,” Cell 187, no. 15 (July 2024): 3885–3887.
Jichao Sun et al., „Gene-based therapies for neurodegenerative diseases,” Nature Neuroscience 24, no. 3 (March 2021): 297–311.
Jiewen Chen et al., „A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation,” Proceedings of the National Academy of Sciences of the USA 121, no. 20 (May 2024): e2306776121.
Jihoon Han et al., „Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer’s disease,” Science Translational Medicine 16, no. 759 (2024): eadi4830.
Jimena Tatiana Hathaway et al., „Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide,” JAMA Ophthalmology (July 2024).
Jimi Olaghere, „I received the new gene-editing drug for sickle-cell disease. It changed my life,” MIT Technology Review, December 4, 2023, https://www.technologyreview.com/2023/12/04/1084209/vertex-exacel-approval-gene-editing-sickle-cell-disease-patient/.
Jimmy Liu et al., „The burden of rare protein-truncating genetic variants on human lifespan,” Nature Aging 2, no. 4 (April 2022): 289–294.
Jinchao Hou et al., „Antibody-mediated targeting of human microglial leukocyte ig-like receptor b4 attenuates amyloid pathology in a mouse model,” Science Translational Medicine 16, no. 741 (April 2024): eadj9052.
Jin Choi et al., „First-line therapy for type 2 diabetes with sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: A cost-effectiveness study,” Annals of Internal Medicine 175, no. 10 (October 2022): 1392–400.
Jingen Zhu et al., „Design of bacteriophage t4-based artificial viral vectors for human genome remodeling,” Nature Communications 14, no. 1 (May 2023): 2928.
Jingjing Lyu et al., „Identification of biomarkers and potential therapeutic targets for pancreatic cancer by proteomic analysis in two prospective cohorts,” Cell Genomics 4, no. 6 (June 2024): 100561.
Jingxuan Zhao et al., „Loneliness and mortality risk among cancer survivors in the United States: A retrospective, longitudinal study,” Journal of the National Comprehensive Cancer Network 22, no. 4 (April 2024): 244–248.
Jinlin Wang et al., „Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives,” Cell Stem Cell 30, no. 9 (September 2023): 1130–1147.
Jinyan Liu et al., „CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques,” Science Immunology 7, no. 77 (November 2022): eabq7647.
Jinzhuo Wang et al., „Accurate estimation of biological age and its application in disease prediction using a multimodal image transformer system,” Proceedings of the National Academy of Sciences of the USA 121, no. 3 (January 2024): e2308812120.
J Keith Joung et al., „TALENS: A widely applicable technology for targeted genome editing,” Nature Reviews Molecular Cell Biology 14, no. 1 (January 2013): 49–55.
JN Morris et al., „Coronary heart disease and physical activity of work,” British Medical Journal (1958): 1485–1496.
Joachim Johansen et al., „Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan,” Nature Microbiology 8, no. 6 (June 2023): 1064–1078.
Joana Pereira et al., „DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical lewy body disease,” Nature Aging 3, no. 10 (October 2023): 1201–9.
Joan Mannick et al., „mTOR inhibition improves immune function in the elderly,” Science Translational Medicine 6, no. 268 (December 2014): 268ra179.
Joan Mannick et al., „Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: Phase 2b and Phase 3 randomised trials,” Lancet Healthy Longevity 2, no. 5 (May 2021): e250–e62.
Joanna Kaplanis et al., „Quantitative analysis of population-scale family trees with millions of relatives,” Science 360, no. 6385 (April 2018): 171–175.
Joanna Moncrieff et al., „The serotonin theory of depression: A systematic umbrella review of the evidence,” Molecular Psychiatry 28, no. 8 (August 2023): 3243–3256.
JoAnn Manson et al., „Marine n-3 fatty acids and prevention of cardiovascular disease and cancer,” New England Journal of Medicine 380, no. 1 (January 2019): 23–32.
Jocelyn Kaiser, „A gentler way to tweak genes: Epigenome editing,” Science 376, no. 6597 (June 2022): 1034–1035.
Jocelyn Kaiser, „Baby steps,” Science News, September 23, 2021, https://www.science.org/content/article/sequence-every-newborn-s-dna-despite-obstacles-uk-pushes-ahead.
Jocelyn Kaiser, „The most common Alzheimer’s risk gene may also protect against memory loss,” Science News, October 7, 2021, https://www.science.org/content/article/most-common-alzheimer-s-risk-gene-may-also-protect-against-memory-loss.
Joel Achenbach et al., „An epidemic of chronic illness is killing us too soon,” Washington Post, October 3, 2023, https://www.washingtonpost.com/health/interactive/2023/american-life-expectancy-dropping/?itid=lk_inline_manual_22.
Joel Achenbach et al., „New CDC life expectancy data shows painfully slow rebound from Covid,” Washington Post, November 29, 2023, https://www.washingtonpost.com/health/2023/11/29/life-expectancy-2022-united-states/.
Joel Blanchard et al., „APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes,” Nature 611, no. 7937 (November 2022): 769–779.
Joel Perlmutter, „FDA’s green light, science’s red light,” 372, no. 6549 (June 2021), https://doi.org/doi.org/10.1126/science.abk0575.
Joel Rurik et al., „CAR T cells produced in vivo to treat cardiac injury,” Science 375, no. 6576 (January 2022): 91–96.
Johanna Chapin-Bardales et al., „Reactogenicity following receipt of mRNA-based Covid-19 vaccines,” JAMA 325, no. 21 (June 2021): 2201–2.
Johanna Chiffelle et al., „Personalized cancer T-cell therapy takes the stage, mirroring vaccine success,” Journal of Experimental Medicine 221, no. 8 (2024), https://doi.org/10.1084/jem.20240854.
Johanna Habicht et al., „Closing the accessibility gap to mental health treatment with a personalized self-referral chatbot,” Nature Medicine 30, no. 2 (February 2024): 595–602.
John Anderson, „Combining glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors to target multiple organ defects in type 2 diabetes,” Diabetes Spectrum 33, no. 2 (May 2020): 165–174.
John Brownstein et al., „Advances in artificial intelligence for infectious-disease surveillance,” New England Journal of Medicine 388, no. 17 (April 2023): 1597–607.
John Gorzynski et al., „Ultrarapid nanopore genome sequencing in a critical care setting,” New England Journal of Medicine 386, no. 7 (February 2022): 700–702.
John Kelly et al., „Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat,” Journal of Psychiatric Research 82 (November 2016): 109–118.
John McNeil et al., „Effect of aspirin on all-cause mortality in the healthy elderly,” New England Journal of Medicine 379, no. 16 (October 2018): 1519–1528.
John Sims et al., „Donanemab in early symptomatic Alzheimer disease: The TRAIL-BLAZER-ALZ2 randomized clinical trial,” JAMA 330, no. 6 (2023): 512–527.
John Torous et al., „Digital mental health’s unstable dichotomy-wellness and health,” JAMA Psychiatry (April 2024).
John Wilding et al., „Once-weekly semaglutide in adults with overweight or obesity,” New England Journal of Medicine 384, no. 11 (March 2021): 989–1002.
Joline Ingels et al., „Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum,” Cell Reports Medicine 5, no. 5 (May 2024): 101516.
Jonathan Cedernaes et al., „Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans,” Science Advances 4, no. 8 (August 2018): eaar8590.
Jonathan Kipnis, „The anatomy of brainwashing,” Science 385, no. 6707 (July 2024): 368–370.
Jonathan Mizrahi et al., „Pancreatic cancer,” Lancet 395, no. 10242 (June 2020): 2008–2020.
Jonathan Stokes et al., „A deep learning approach to antibiotic discovery,” Cell 180, no. 4 (February 2020): 688–702 e13.
Jonathan Wosen, „Cancer is rising among the young. Study suggests it’s because their cells are aging faster,” STAT News, April 7, 2024, https://www.statnews.com/2024/04/07/cancer-rates-young-aging-cells/.
Jonathan Wosen, „Ultima genomics launching high-end DNA sequencers that can read genome for $100,” STAT News, January 30, 2024, https://www.statnews.com/2024/01/30/ultima-genomics-dna-sequencing-100-dollars/#:~:text=Ultima%20Genomics%20launching%20high%2Dend,can%20read%20genome%20for%20%24100&text=Ultima%20 Genomics%2C%20an%20upstart,the%20company’s%20leadership%20told%20STAT.
Jon Cohen, „The dream vaccine,” Science 372, no. 6539 (April 2021): 227–231.
Jon LaPook, „Mental health chatbots powered by artificial intelligence developed as a therapy support tool,” April 7, 2024, https://www.cbsnews.com/news/mental-health-chatbots-powered-by-artificial-intelligence-providing-support-60-minutes-transcript/.
Jordi Merino et al., „Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits,” Nature Human Behaviour 6, no. 1 (January 2022): 155–163.
Jordi Merino et al., „Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts,” PLOS Medicine 19, no. 4 (April 2022): e1003972.
Jorge Correale et al., „The role of the gut microbiota in multiple sclerosis,” Nature Reviews Neurology 18, no. 9 (September 2022): 544–558.
Jose Moreira et al., „Exercise and cardiac health: Physiological and molecular insights,” Nature Metabolism 2, no. 9 (September 2020): 829–839.
Joseph Arboleda-Velasquez et al., „Resistance to autosomal dominant Alzheimer’s disease in an APOE3 christchurch homozygote: A case report,” Nature Medicine 25, no. 11 (November 2019): 1680–1683.
Joseph Beals et al., „Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes,” Nature Metabolism 5, no. 7 (July 2023): 1221–1235.
Joseph Doyle et al., „Effect of an intensive food-as-medicine program on health and health care use: A randomized clinical trial,” JAMA Internal Medicine 184, no. 2 (February 2024): 154–163.
Joseph Firth et al., „Food and mood: How do diet and nutrition affect mental wellbeing?,” British Medical Journal 369 (June 2020): m2382.
Joseph Herdy et al., „Neuronal senescence may drive brain aging,” Science 384, no. 6703 (2024): 1404–6.
Joseph Unger et al., „Using medicare claims to examine long-term prostate cancer risk of finasteride in the prostate cancer prevention trial,” Journal of the National Cancer Institute 110, no. 11 (November 2018): 1208–1215.
Joshua Goldenberg et al., „Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: Systematic review and meta-analysis of published and unpublished randomized trial data,” British Medical Journal 372 (January 2021): m4743.
Joshua Gottesman et al., „Fox insight at 5 years—a cohort of 54,000 participants contributing longitudinal patient-reported outcome, genetic, and microbiome data relating to Parkinson’s disease,” Scientific Data 11, no. 1 (June 2024): 615.
Joshua Hyde et al., „Efficacy of neurostimulation across mental disorders: Systematic review and meta-analysis of 208 randomized controlled trials,” Molecular Psychiatry 27, no. 6 (June 2022): 2709–2719.
Joshua Siegel et al., „Psilocybin desynchronizes the human brain,” Nature 632, no. 8023 (August 2024): 131–138.
Josh Whalen, Better Bloke, August 7, 2024, https://blokes.co/staying-young/dr-peter-attias-recommended-supplement-stack/.
Jos Lelieveld et al., „Air pollution deaths attributable to fossil fuels: Observational and modelling study,” British Medical Journal 383 (November 2023): e077784.
José A. Joglar et al., „2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: A report of the American college of cardiology/American heart association joint committee on clinical practice guidelines,” Circulation 149, no. 1 (2024): e1–e156.
Jotham Suez et al., „Artificial sweeteners induce glucose intolerance by altering the gut microbiota,” Nature 514, no. 7521 (October 2014): 181–186.
Jotham Suez et al., „Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance,” Cell 185, no. 18 (September 2022): 3307–3328 e19.
Joy Wang et al., „CRISPR technology: A decade of genome editing is only the beginning,” Science 379, no. 6629 (January 2023): eadd8643.
João Pedro de Magalhães, „Cellular senescence in normal physiology,” Science 384, no. 6702 (2024): 1300–1301.
Juan Antonio Fafian-Labora et al., „Classical and nonclassical intercellular communication in senescence and ageing,” Trends in Cell Biology 30, no. 8 (August 2020): 628–639.
Juan Fortea et al., „APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease,” Nature Medicine 30, no. 5 (May 2024): 1284–1291.
Juan Manuel Povedano et al., „Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres,” eLife 7 (January 2018): e31299.
Judith Stern, „Ethan Allen Sims (1916–2010),” Obesity 19, no. 3 (March 2011): 467.
Juergen Rech et al., „Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): A randomised, international, multicentre, double-blind, placebo-controlled trial,” Lancet 403, no. 10429 (March 2024): 850–859.
Juhyun Oh et al., „Stem cell aging: Mechanisms, regulators and therapeutic opportunities,” Nature Medicine 20, no. 8 (August 2014): 870–880.
Julia Baudry et al., „Dietary pesticide exposure and non-communicable diseases and mortality: A systematic review of prospective studies among adults,” Environmental Health 22, no. 1 (October 2023): 76.
Julia Carrasco-Zanini et al., „Proteomic prediction of di-verse incident diseases: A machine learning-guided biomarker discovery study using data from a prospective cohort study,” Lancet Digital Health 6, no. 7 (July 2024): e470–e79.
Julia Carrasco-Zanini et al., „Proteomic signatures improve risk prediction for common and rare diseases,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03142-z.
Julian De Freitas et al., „AI Wellness apps,” Nature Medicine 30, no. 5 (May 2024): 1269–1275.
Julian De Freitas et al., „The health risks of generative AI-based wellness apps,” Nature Medicine 30, no. 5 (May 2024): 1269–1275.
Julian Gillmore et al., „CRISPR-cas9 in vivo gene editing for transthyretin amyloidosis,” New England Journal of Medicine 385, no. 6 (August 2021): 493–502.
Julian Packheiser et al., „A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions,” Nature Human Behavior (April 2024).
Julia Tcw et al., „Cholesterol and matrisome pathways dysregulated in astrocytes and microglia,” Cell 185, no. 13 (June 2022): 2213–2233 e25.
Julie Garcia et al., „Naturally occurring T cell mutations enhance engineered T cell therapies,” Nature 626, no. 7999 (February 2024): 626–634.
Julie Mattison et al., „Caloric restriction improves health and survival of rhesus monkeys,” Nature Communications 8, no. 14063 (January 2017): 1–12.
Julie Paik et al., „Sodium-glucose cotransporter 2 inhibitors and nephrolithiasis risk in patients with type 2 diabetes,” JAMA Internal Medicine 184, no. 3 (March 2024): 265–274.
Julio Aguado et al., „Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology,” Nature Aging 3, no. 12 (December 2023): 1561–1575.
Julio Leon et al., „Peripheral elevation of a Klotho fragment enhances brain function and resilience in young, aging, and alpha-synuclein transgenic mice,” Cell Reports 20, no. 6 (August 2017): 1360–1371.
Junfeng Zhang, „Low-level air pollution associated with death: Policy and clinical implications,” JAMA 318, no. 24 (December 2017): 2431–2432.
Junhao Wen et al., „The genetic architecture of biological age in nine human organ systems,” Nature Aging (June 2024).
Jun Liu, „Targeting cancer with molecular glues,” Science 381, no. 6659 (August 2023): 729–730.
Jun Lv et al., „AAV1-hOTOF gene therapy for autosomal recessive deafness 9: A single-arm trial,” Lancet (January 2024), https://doi.org/10.1016/S0140-6736(23)02874-X.
Junxian Ou et al., „Tracking SARS-CoV-2 omicron diverse spike gene mutations identifies multiple inter-variant recombination events,” Signal Transduction and Targeted Therapy 7, no. 1 (April 2022): 138.
Jun Yan et al., „Improving prime editing with an endogenous small RNA-binding protein,” Nature 628, no. 8008 (April 2024): 639–647.
Junzhe Huang et al., „Functional and multiomic aging rejuvenation with GLP-1r agonism,” bioRxiv, May 8, 2024, https://doi.org/10.1101/2024.05.06.592653.
Jurgen Gotz et al., „Ultrasound and antibodies—a potentially powerful com-bination for Alzheimer disease therapy,” Nature Reviews Neurology 20, no. 5 (May 2024): 257–258.
Justin Long et al., „Alzheimer disease: An update on pathobiology and treatment strategies,” Cell 179, no. 2 (October 2019): 312–339.
Justin Randall et al., „Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity,” Nature Biomedical Engineering 8, no. 7 (July 2024): 842–853.
JW Shay et al., „Hayflick, his limit, and cellular ageing,” Nature Reviews Molecular Cell Biology 1, no. 1 (October 2000): 72–76.
Kai Cao et al., „Large-scale pancreatic cancer detection via non-contrast CT and deep learning,” Nature Medicine 29, no. 12 (December 2023): 3033–3043.
Kai Jia et al., „A pancreatic cancer risk prediction model (Prism) developed and validated on large-scale US clinical data,” EBioMedicine 98 (December 2023): 104888.
Kai Luo et al., „Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes,” Nature Metabolism 6, no. 1 (January 2024): 169–186.
Kalina Paunovska et al., „Drug delivery systems for RNA therapeutics,” Nature Reviews Genetics 23, no. 5 (May 2022): 265–280.
Karen Corbin et al., „Host-diet-gut microbiome interactions influence human energy balance: A randomized clinical trial,” Nature Communications 14, no. 1 (May 2023): 3161.
Karin Dembrower et al., „Artificial intelligence for breast cancer detection in screening mammography in Sweden: A prospective, population-based, paired-reader, non-inferiority study,” Lancet Digital Health 5, no. 10 (October 2023): e703–e11.
Karine Thai et al., „CNS therapeutics: Immune cells break the barriers,” Science Translational Medicine 15, no. 721 (November 2023): eadh1150.
Karishma D’Sa et al., „Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models,” Nature Machine Intelligence 5, no. 8 (August 2023): 933–946.
Kate Bermingham et al., „Effects of a personalized nutrition pro-gram on cardiometabolic health: A randomized controlled trial,” Nature Medicine 30, no. 7 (July 2024): 1888–1897.
Kate Creevy et al., „An open science study of ageing in companion dogs,” Nature 602, no. 7895 (February 2022): 51–57.
Katharina Woess et al., „Cancer spread in the liver is unlocked from within,” Nature 632, no. 8024 (August 2024): 262–264.
Katharine Henry et al., „Factors driving provider adoption of the TREWS machine learning-based early warning system and its effects on sepsis treatment timing,” Nature Medicine 28, no. 7 (July 2022): 1447–1454.
Katharine Henry et al., „Human–machine teaming is key to AI adoption: Clinicians’ experiences with a deployed machine learning system,” NPJ Digital Medicine 5, no. 1 (July 2022): 97.
Katherine Scangos et al., „New and emerging approaches to treat psychiatric disorders” Nature Medicine 29 (February 2023): 317–333.
Katherine Simon et al., „A randomized, controlled clinical trial demonstrates improved cognitive function in senior dogs supplemented with a senolytic and NAD+ precursor combination,” bioRxiv, February 28, 2024.
Kathie Ngo et al., „Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use,” NPJ Parkinson’s Disease 10, no. 1 (April 2024): 87.
Kathleen Neuzil, „An mRNA influenza vaccine—could it deliver?,” New England Journal of Medicine 388, no. 12 (March 2023): 1139–1141.
Kathryn Crawford et al., „Patterns of seafood consumption among New Hampshire residents suggest potential exposure to per- and polyfluoroalkyl substances,” Exposure and Health (April 2024), https://doi.org/10.1007/s12403-024-00640-w.
Katrina Kalantar et al., „Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults,” Nature Microbiology 7, no. 11 (November 2022): 1805–1816.
Katrina Piercy et al., „The physical activity guidelines for Americans,” JAMA 320, no. 19 (November 2018): 2020–2028.
Kausik Ray et al., „Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (orion-3): Results from the 4-year open-label extension of the orion-1 trial,” Lancet Diabetes Endocrinology 11, no. 2 (February 2023): 109–119.
Kausik Ray et al., „Safety and efficacy of bempedoic acid to reduce LDL cholesterol,” New England Journal of Medicine 380, no. 11 (March 2019): 1022–1032.
Kayarash Karimian et al., „Human telomere length is chromosome end-specific and conserved across individuals,” Science 384, no. 6695 (May 2024): 533–539.
KDM Snell, „The rise of living alone and loneliness in history,” Social His-tory 42, no. 1 (January 2017): 2–28.
Kehinde Sharafadeen Okunade, „Human papillomavirus and cervical cancer,” Journal of Obstetrics and Gynaecology 40, no. 5 (July 2020): 602–8.
Kejun Ying et al., „Causality-enriched epigenetic age uncouples damage and adaptation,” Nature Aging 4, no. 2 (February 2024): 231–246.
Kelly Frazer et al., „Human genetic variation and its contribution to complex traits,” Nature Reviews Genetics 10, no. 4 (April 2009): 241–251.
Kelsey Piper, „Operation Warp Speed was a huge success. So why is the US turning away from it?,” Vox, January 18, 2023, https://www.vox.com/future-perfect/2023/1/18/23560407/operation-warp-speed-pandemics-vaccines-covid-white-house-biden-trump.
Kelvin Wu et al., „An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance,” Science 383, no. 6684 (February 2024): 721–726.
Kenji Kawai et al., „Subclinical atherosclerosis: Part 1: What is it? Can it be defined at the histological level?,” Arteriosclerosis, Thrombosis, and Vascular Biology 44, no. 1 (January 2024): 12–23.
Kenneth Chan et al., „Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: The ORFAN multicentre, longitudinal cohort study,” Lancet 403, no. 10444 (June 2024): 2606–2618.
Kenneth Kochanek et al., Deaths: Final Data for 2020, vol. 72, National Center for Health Statistics (Hyattsville, MD, September 2023), 1–75, https://www.cdc.gov/nchs/data/nvsr/nvsr72/nvsr72-10.pdf.
Kenneth Rockwood et al., „Genetic predisposition and modifiable risks for late-life dementia,” Nature Medicine 25, no. 9 (September 2019): 1331–1332.
Kerstin Vokinger et al., „Sources of innovation in gene therapies—approaches to achieving affordable prices,” New England Journal of Medicine 388, no. 4 (January 2023): 292–295.
Kevin Guttenplan, „Why do neurons die?,” Science 378, no. 6619 (November 2022): 485.
Kevin Hall et al., „Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake,” Cell Metabolism 30, no. 1 (July 2019): 67–77 e3.
Kevin Kaczorowski et al., „Continuous immunotypes describe human immune variation and predict diverse responses,” Proceedings of the National Academy of Sciences 114, no. 30 (July 2017): E6097-E106.
Khai Tran et al., „Floatation therapy for mental health conditions,” Canadian Journal of Health Technologies 1, no. 12 (December 2021): 1–30.
Kimberly Ha, „Egenesis announces world’s first successful transplant of genetically engineered porcine kidney in a living patient,” eGenesis, March 21, 2024, https://egenesisbio.com/press-releases/egenesis-announces-worlds-first-successful-transplant-of-genetically-engineered-porcine-kidney-in-a-living-patient/.
Kimia Shafighi et al., „Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias,” PLoS One 18, no. 2 (February 2023): e0280471.
Kim Tingley, „ ‘Forever chemicals’ are everywhere. What are they doing to us?,” New York Times Magazine, August 16, 2023, https://www.nytimes.com/2023/08/16/magazine/pfas-toxic-chemicals.html?action=click&pgtype=Article&state=default&module=styln-pfas-forever-chemicals&variant=show®ion=BELOW_MAIN_CONTENT&block=storyline_flex_guide_recirc.
Kiran Biddinger et al., „Association of habitual alcohol intake with risk of cardiovascular disease,” JAMA Network Open 5, no. 3 (March 2022): e223849.
Kiran Musunuru et al., „In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates,” Nature 593, no. 7859 (May 2021): 429–434.
Kirsi-Marja Zitting et al., „Human resting energy expenditure varies with circadian Phase,” Current Biology 28, no. 22 (November 2018): 3685–3690 e3.
Kirsten Berding et al., „Feed your microbes to deal with stress: A psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population,” Molecular Psychiatry 28, no. 2 (February 2023): 601–610.
Kirsten McMillan et al., „Longevity of companion dog breeds: Those at risk from early death,” Scientific Reports 14, no. 1 (February 2024): 531.
Kjetil Bjornevik et al., „Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis,” Science 375, no. 6578 (January 2022): 296–301.
Klodian Dhana et al., „Healthy lifestyle and cognition in older adults with common neuropathologies of dementia,” JAMA Neurology 81, no. 3 (March 2024): 233–239.
Kristen Browder et al., „In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice,” Nature Aging 2, no. 3 (March 2022): 243–253.
Kristen Muñoz et al., „A gram-negative-selective antibiotic that spares the gut microbiome,” Nature 630, no. 8016 (June 2024): 429–436.
Krister Kauppi, „Post on longevity leaders taking Rapamycin,” X, October 4, 2023, https://x.com/KristerKauppi/status/1704073641888039392.
Ksenija Velickovic et al., „Caffeine exposure induces browning features in adipose tissue in vitro and in vivo,” Scientific Reports 9, no. 1 (June 2019): 9104.
Kuei-Pin Huang et al., „Dissociable hindbrain GLP1R circuits for satiety and aversion,” Nature (July 2024).
Kunal Ahuja et al., „Nicotinamide adenine dinucleotide market size,” Global Market Insights, September 2022, https://www.gminsights.com/industry-analysis/nicotinamide-adenine-dinucleotide-market.
Kunal Potnis et al., „Artificial intelligence in breast cancer screening: Evaluation of FDA device regulation and future recommendations,” JAMA Internal Medicine 182, no. 12 (December 2022): 1306–1312.
Kyle Swanson et al., „From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment,” Cell 186, no. 8 (April 2023): 1772–1791.
Kyle Swanson et al., „Generative AI for designing and validating easily synthesizable and structurally novel antibiotics,” Nature Machine Intelligence 6 (March 2024): 338–353.
Kyohei Tokizane et al., „DMH(Ppp1r17) neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication,” Cell Metabolism 36, no. 2 (February 2024): 377–392 e11.
Kyu Sik Kim et al., „GLP-1 increases preingestive satiation via hypo-thalamic circuits in mice and humans,” Science 385, no. 6707 (2024): 438–446.
Lachlan Cribb et al., „Sleep regularity and mortality: A prospective analysis in the UK Biobank,” eLife 12 (November 2023): RP88359.
Laia Reverte-Salisa et al., „EPAC1 enhances brown fat growth and beige adipogenesis,” Nature Cell Biology 26, no. 1 (January 2024): 113–123.
Lakshmi Varanasi, „Longevity clinics for the ultrawealthy can cost $50,000 a week. Here are the world’s top 6 destinations,” Business Insider, April 18, 2024, https://www.businessinsider.com/longevity-clinics-are-next-iteration-luxury-biohack-live-longer-wealthy-2023-11.
Lars Fadnes et al., „Estimating impact of food choices on life expectancy: A modeling study,” PLOS Medicine 19, no. 2 (February 2022): e1003889.
LaTonya Hickson et al., „Senolytics decrease senescent cells in hu-mans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease,” EBioMedicine 47 (September 2019): 446–456.
Laura Bucci et al., „Bispecific T cell engager therapy for refractory rheumatoid arthritis,” Nature Medicine 30, no. 6 (April 2024): 1593–601.
Laura Helmuth, „Vitamin D hope and hype, cosmic voids and preventing depression,” Scientific American, January 1, 2024, https://www.scientificamerican.com/article/vitamin-d-hope-and-hype-cosmic-voids-and-preventing-depression/.
Laura Jacobson et al., „Losing sleep with age,” Science 375, no. 6583 (February 2022): 816–817.
Laura Lewis, „The interconnected causes and consequences of sleep in the brain,” Science 374, no. 6567 (October 2021): 564–568.
Laura Matarazzo et al., „mRNA vaccines: A new opportunity for malaria, tuberculosis and HIV,” Frontiers in Immunology 14 (April 2023): 1172691.
Laura Stevens et al., „Association between coffee intake and incident heart failure risk: A machine learning analysis of the FHS, the ARIC study, and the CHS,” Circulation Heart Failure 14, no. 2 (February 2021): e006799.
Lauren F. Friedman, „How to reduce your exposure to plastic in food (and everywhere else),” Consumer Reports, January 4, 2024, https://www.consumerreports.org/health/food-contaminants/how-to-reduce-exposure-to-plastic-in-food-everywhere-else-a9640874767/#:~:text=You%20can%20see%20CR%27s%20top,limit%20consumption%20of%20fast%20food.
Lauren Hablitz et al., „Synchronized neuronal activity drives waste fluid flow,” Nature 627, no. 8002 (March 2024): 44–45.
Lauren McCarthy, „A wellness chatbot is offline after its ‘harmful’ focus on weight loss,” New York Times, June 8, 2023, https://www.nytimes.com/2023/06/08/us/ai-chatbot-tessa-eating-disorders-association.html.
Laure Surgers et al., „Metagenomics for diagnosis of complex infections: A prospective multicenter study,” Lancet, February 27, 2024, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4736596.
Lawrence Jin et al., „Sleep, health, and human capital: Evidence from daylight saving time,” Journal of Economic Behavior & Organization (February 2020): 174–192.
Lawrence Young, „Epstein-Barr virus at 60,” Nature 627, no. 8004 (March 2024): 492–494.
Leandro Garcia et al., „Non-occupational physical activity and risk of cardio-vascular disease, cancer and mortality outcomes: A dose-response meta-analysis of large prospective studies,” British Journal of Sports Medicine 57, no. 15 (August 2023): 979–989.
Le Cong et al., „Multiplex genome engineering using CRISPR/Cas systems,” Science 339, no. 6121 (February 2013): 819–823.
Leigh Turner, „The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions,” Cell Stem Cell 28, no. 11 (November 2021): 1891–1895.
Lei Zhao et al., „Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic musculoskeletal pain,” Nature Mental Health 2 (March 2024): 435–499.
Lenka Boyd et al., „Prediction model for early-stage pancreatic cancer using routinely measured blood biomarkers,” JAMA Network Open 6, no. 8 (August 2023): e2331197.
Lenka Dohnalova et al., „A microbiome-dependent gut-brain pathway regulates motivation for exercise,” Nature 612, no. 7941 (December 2022): 739–747.
Leo Akioyamen et al., „Estimating the prevalence of heterozygous familial hypercholesterolaemia: A systematic review and meta-analysis,” BMJ Open 7, no. 9 (September 2017): e016461.
Leroy Leo et al., „US FDA approves two gene therapies for sickle cell disease,” Reuters, December 8, 2023, https://www.reuters.com/business/healthcare-pharmaceuticals/us-approves-two-gene-therapies-sickle-cell-disease-2023-12-08/.
Lewina Lee et al., „Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women,” Proceedings of the National Academy of Sciences of the USA 116, no. 37 (September 2019): 18357–8362.
Liang Li et al., „White adipocytes in subcutaneous fat depots require klf15 for maintenance in preclinical models,” Journal of Clinical Investigation 134, no. 13 (July 2024), https://doi.org/10.1172/JCI172360.
Lieselotte Vande Walle et al., „Drugging the NLRP3 inflammasome: From signalling mechanisms to therapeutic targets,” Nature Reviews Drug Discovery 23, no. 1 (January 2024): 43–66.
Lifeng Li, „Loneliness, social isolation with the risk of lung cancer among middle and old population: A prospective cohort and Mendelian randomization analysis,” Preprints with The Lancet (July 2024).
Lijun Ning et al., „Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy,” Cell 187, no. 13 (June 2024): 3231–3232.
Liliana Sanmarco et al., „Lactate limits CNS autoimmunity by stabilizing HIF-1alpha in dendritic cells,” Nature 620, no. 7975 (August 2023): 881–889.
Limin Hao et al., „Development of a clinical polygenic risk score assay and reporting workflow,” Nature Medicine 28, no. 5 (May 2022): 1006–1013.
Lindor Qunaj et al., „Prognostic and therapeutic impact of the KRAS g12c mutation in colorectal cancer,” Frontiers in Oncology 13 (September 2023): 1252516.
Lindsay Collin et al., „Association of sugary beverage consumption with mortality risk in US adults: A secondary analysis of data from the regards study,” JAMA Network Open 2, no. 5 (May 2019): e193121.
Lindsay Jost, „Therapeutic plasma exchange 101: Get answers to your questions,” accessed June 26, 2024, https://maxwellclinic.com/therapeutic-plasma-exchange-101/.
Lindsey Baden et al., „Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine,” New England Journal of Medicine 384, no. 5 (February 2021): 403–416.
Lindsey Vansandt et al., „Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene,” Nature Communications 14, no. 1 (June 6, 2023): 3140.
Lindsey Wang et al., „GLP-1 receptor agonists and colorectal cancer risk in drug-naive patients with type 2 diabetes, with and without overweight/obesity,” JAMA Oncology 10, no. 2 (February 2024): 256–258.
Lindsey Wang et al., „Glucagon-like peptide 1 receptor agonists and 13 obesity-associated cancers in patients with type 2 diabetes,” JAMA Network Open 7, no. 7 (2024): e2421305-e05.
Lisa Barnes et al., „Trial of the mind diet for prevention of cognitive decline in older persons,” New England Journal of Medicine 389, no. 7 (August 2023): 602–611.
Liz Lee et al., „Robust and interpretable AI-guided marker for early dementia prediction in real-world clinical settings,” EClinicalMedicine (July 2024).
Lizzy Lawrence et al., „Experts split on whether Eli Lilly’s Zepbound will ham-per CPAP sales,” STAT News, June 25, 2024, https://www.statnews.com/2024/06/25/eli-lilly-zepbound-sleep-apnea-cpap-machines-obsolete/.
Longxiang Li et al., „High-resolution national radon maps based on massive indoor measurements in the United States (preprint),” Preprints with The Lancet, April 22, 2024, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4800406.
Lonneke van Tuijl et al., „Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis,” Cancer 129, no. 20 (October 2023): 3287–3299.
Lorenzo Talamanca et al., „Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans,” Science 379, no. 6631 (February 2023): 478–483.
Lori Khrimian et al., „Gpr158 mediates osteocalcin’s regulation of cognition,” Journal of Experimental Medicine 214, no. 10 (October 2017): 2859–2873.
Lou Delval et al., „Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters,” Nature Aging 3, no. 7 (July 2023): 829–845.
Luca Busetto et al., „A new framework for the diagnosis, staging and management of obesity in adults,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03095-3.
Lucas Jurado-Fasoli et al., „Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts,” EBioMedicine 100 (February 2024): 104948.
Lucia Migliore et al., „Gene-environment interactions in Alzheimer disease: The emerging role of epigenetics,” Nature Reviews Neurology 18, no. 11 (November 2022): 643–660.
Ludger Goeminne et al., „Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems,” medRxiv (2024): 2024.04.08.24305469.
Ludvig Sollid, „Epstein-Barr virus as a driver of multiple sclerosis,” Science Immunology 7, no. 70 (April 2022): eabo7799.
Ludvig Sollid, „Tolerance-inducing therapies in coeliac disease—mechanisms, progress and future directions,” Nature Reviews Gastroenterology & Hepatology 21, no. 5 (May 2024): 335–347.
Luisa Flor et al., „Health effects associated with exposure to second-hand smoke: A burden of proof study,” Nature Medicine 30, no. 1 (January 2024): 149–167.
Luis Ciria et al., „An umbrella review of randomized control trials on the effects of physical exercise on cognition,” Nature Human Behaviour 7, no. 6 (June 2023): 928–941.
Luis Rojas et al., „Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer,” Nature 618, no. 7963 (June 2023): 144–150.
Lukas Mager et al., „Interaction of microbiota, mucosal malignancies, and immunotherapy-mechanistic insights,” Mucosal Immunology 17, no. 3 (June 2024): 402–415.
Luke Koblan et al., „In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice,” Nature 589, no. 7843 (January 2021): 608–614.
Lu Liu et al., „Choline intake correlates with cognitive performance among elder adults in the United States,” Behavioural Neurology 2021 (October 2021): 2962245.
Lydia Denworth, „Now there are better ways than BMI charts to assess health risks,” Scientific American, January 1, 2024, https://www.scientificamerican.com/article/now-there-are-better-ways-than-bmi-charts-to-assess-health-risks/.
Lynette Denny et al., „Cervical cancer kills 300,000 people a year—here’s how to speed up its elimination,” Nature 626, no. 7997 (February 2024): 30–32.
M. Austin Argentieri et al., „Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations,” Nature Medicine (August 2024), https://doi.org/10.1038/s41591-024-03164-7.
M. Charles Liberman, „Hidden hearing loss from everyday noise,” Scientific American, August 1, 2015.
M. Cojocaru et al., „Multiple autoimmune syndrome,” Maedica (Bucur) 5, no. 2 (April 2010): 132–134.
M. de Lorgeril et al., „Mediterranean alpha-linolenic acid-rich diet in second-ary prevention of coronary heart disease,” Lancet 343, no. 8911 (June 1994): 1454–1459.
M. Guasch-Ferre et al., „Are fruit juices just as unhealthy as sugar-sweetened beverages?,” JAMA Network Open 2, no. 5 (May 3, 2019): e193109.
M. Reinert et al., „The state of mental health in America 2023,” Mental Health America (Alexandria, VA, October, 2022), 1–38, https://mhanational.org/sites/default/files/2023-State-of-Mental-Health-in-America-Report.pdf.
Mabel Seto et al., „Parental history of memory impairment and β-amyloid in cognitively unimpaired older adults,” JAMA Neurology 81, no. 8 (2024): 798–804.
Mackenzie Bender et al., „Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment,” Cell 186, no. 9 (April 2023): 1846–1862 e26.
MacLean Sellars et al., „Cancer vaccines: Building a bridge over troubled waters,” Cell 185, no. 15 (July 2022): 2770–2788.
Madeleine Speed et al., „ ‘Deny, denounce, delay’: The battle over the risk of ultra-processed foods,” arsTechnica, May 25, 2024, https://arstechnica.com/science/2024/05/deny-denounce-delay-the-battle-over-the-risk-of-ultra-processed-foods/.
Madelynn Whittaker et al., „An epigenetic editor to silence genes,” Science 384, no. 6703 (2024): 1407–8.
Mads Bloch-Ibenfeldt et al., „Heavy resistance training at retirement age in-duces 4-year lasting beneficial effects in muscle strength: A long-term follow-up of an RCT,” BMJ Open Sport & Exercise Medicine 10, no. 2 (June 2024): e001899.
MA Epstein et al., „Virus particles in cultured lymphoblasts from Burkitt’s lymphoma,” Lancet 1, no. 7335 (March 1964): 702–3.
Manfre Hallschmid, „Intranasal insulin,” Journal of Neuroendocrinology 33, no. 4 (April 2021): e12934.
Manlio Vinciguerra et al., „Atrial fibrillation: Pathophysiology, genetic and epigenetic mechanisms,” Lancet Regional Health – Europe 37 (February 2024): 100785.
Manolis Kogevinas et al., „Long-term exposure to air pollution and Covid-19 vaccine antibody response in a general population cohort (COVICAT study, Catalonia),” Environ-mental Health Perspectives 131, no. 4 (April 2023): 47001.
Manuela Neuenschwander et al., „Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: A systematic review and meta-analysis of prospective studies,” BMC Medicine 21, no. 1 (November 2023): 404.
Manuja Sharma et al., „TBscreen: A passive cough classifier for tuberculosis screening with a controlled dataset,” Science Advances 10, no. 1 (January 2024): eadi0282.
Marc Ferrell et al., „A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk,” Nature Medicine 30, no. 2 (February 2024): 424–434.
Marc Gunter et al., „Coffee drinking and mortality in 10 European countries: A multinational cohort study,” Annals of Internal Medicine 167, no. 4 (August 2017): 236–247.
Marcia Jimenez et al., „Residential green space and cognitive function in a large cohort of middle-aged women,” JAMA Network Open 5, no. 4 (April 2022): e229306.
Marco Peres et al., „Oral diseases: A global public health challenge,” Lancet 394, no. 10194 (July 2019): 249–260.
Marc Ryser et al., „Estimation of breast cancer overdiagnosis in a U.S. Breast screening cohort,” Annals of Internal Medicine 175, no. 4 (April 2022): 471–478.
Marcus Boehme et al., „Microbiota from young mice counteracts selective age-associated behavioral deficits,” Nature Aging 1, no. 8 (August 2021): 666–676.
Marcus Goncalves et al., „High-fructose corn syrup enhances intestinal tumor growth in mice,” Science 363, no. 6433 (March 2019): 1345–1349.
Maria Carolina Florian et al., „Inhibition of Cdc42 activity extends lifespan and de-creases circulating inflammatory cytokines in aged female C57BL/6 mice,” Aging Cell 19, no. 9 (September 2020): e13208.
Maria Manfredi-Lozano et al., „GnRH replacement rescues cognition in Down syndrome,” Science 377, no. 6610 (September 2022): eabq4515.
Mariana Lenharo, „Could a rare mutation that causes dwarfism also slow ageing?,” Nature (April 2024), https://doi.org/10.1038/d41586-024-01201-6.
Mariana Lenharo, „Move over, CRISPR: RNA-editing therapies pick up steam,” Nature 626, no. 8001 (February 2024): 933–934.
Mariana Noto Guillen et al., „Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics,” Science 384, no. 6691 (2024): 93–100.
Maria Pascual-Torner et al., „Comparative genomics of mortal and im-mortal cnidarians unveils novel keys behind rejuvenation,” Proceedings of the National Academy of Sciences of the USA 119, no. 36 (September 2022): e2118763119.
Marie Depuydt et al., „Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells,” Nature Cardiovascular Research 2, no. 2 (February 2023): 112–125.
Marijana Vujkovic et al., „Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis,” Nature Genetics 52, no. 7 (July 2020): 680–691.
Marilynn Larkin, „Does EPA lower CV risk? Reduce-it revisited,” Medscape, January 11, 2023, https://www.medscape.com/viewarticle/986837?form=fpf.
Marina Terekhova et al., „Single-cell atlas of healthy human blood unveils age-related loss of NKG2C(+)GZMB(-)CD8(+) memory T cells and accumulation of type 2 memory T cells,” Immunity 56, no. 12 (December 2023): 2836–2854 e9.
Mario Aguilar, „Cognito raises $35 million for Alzheimer’s treatment device, touts benefits compared to drugs,” STAT News, January 29, 2024, https://www.statnews.com/2024/01/29/medical-device-company-cognito-secures-funding-alzheimers-trial/.
Mario Aguilar, „Otsuka’s digital treatment for depression cleared by FDA, as pharma tries to crack tricky market,” STAT News, April 1, 2024, https://www.statnews.com/2024/04/01/otsuka-digital-therapy-depression-gains-fda-clearance/.
Marios Giannakis et al., „A common cancer at an uncommon age,” Science 379, no. 6637 (2023): 1088–1090.
Marius Mader et al., „Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis,” Nature Neuroscience (May 2024): 901–912.
Marjolein Peters et al., „The transcriptional landscape of age in human peripheral blood,” Nature Communications 6 (October 2015): 8570.
Mark Olfson et al., „Trends in psychological distress and outpatient mental health care of adults during the Covid-19 era,” Annals of Internal Medicine 177, no. 3 (March 2024): 353–362.
Markus Wettstein et al., „Postponing old age: Evidence for historical change toward a later perceived onset of old age,” Psychology and Aging (April 2024): online ahead of print, https://doi.org/10.1037/pag0000812.
Maroun Bou Sleiman et al., „Sex- and age-dependent genetics of longevity in a heterogeneous mouse population,” Science 377, no. 6614 (September 2022): eabo3191.
Marta Garo-Pascual et al., „Brain structure and phenotypic profile of super-agers compared with age-matched older adults: A longitudinal analysis from the vallecas project,” Lancet Healthy Longevity 4, no. 8 (August 2023): e374–e85.
Marta Garo-Pascual et al., „Superagers resist typical age-related white matter structural changes,” Journal of Neuroscience 44, no. 25 (April 2024): e2059232024.
Marta Guasch-Ferre et al., „Consumption of olive oil and risk of total and cause-specific mortality among U.S. adults,” Journal of the American College of Cardiology 79, no. 2 (January 2022): 101–112.
Marta Gwinn et al., „Next-generation sequencing of infectious pathogens,” JAMA 321, no. 9 (March 2019): 893–894.
Martina Fiumara et al., „Genotoxic effects of base and prime editing in human hematopoietic stem cells,” Nature Biotechnology (September 7, 2023), https://doi.org/10.1038/s41587-023-01915-4.
Martin Jinek et al., „A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity,” Science 337, no. 6096 (August 2012): 816–821.
Martino Cappelluti et al., „Durable and efficient gene silencing in vivo by hit-and-run epigenome editing,” Nature 627, no. 8003 (March 2024): 416–423.
Mary Armanios, „The role of telomeres in human disease,” Annual Review of Genomics and Human Genetics 23 (August 2022): 363–381.
Mary Birken et al., „Exploring the experiences of loneliness in adults with mental health problems: A participatory qualitative interview study,” PLoS One 18, no. 3 (March 2023): e0280946.
Mary Butler et al., „Man and the microbiome: A new theory of everything?,” Annual Review of Clinical Psychology 15 (May 2019): 371–398.
Mary Yannakoulia et al., „Diets,” New England Journal of Medicine 390, no. 22 (June 2024): 2098–106.
Masashi Fujita et al., „Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain,” Nature Genetics 56, no. 4 (April 2024): 605–614.
Mason Hill et al., „Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment,” Scientific Reports 12, no. 1 (October 2022): 17189.
Massimo Gadina et al., „JAKing up immunity,” Science 384, no. 6702 (June 2024): 1303–4.
Mathew White et al., „Spending at least 120 minutes a week in nature is associated with good health and wellbeing,” Scientific Reports 9, no. 1 (June 2019): 7730.
Mathias Baumert et al., „Sleep characterization with smart wearable devices: A call for standardization and consensus recommendations,” Sleep 45, no. 12 (December 2022): zsac183.
Mathias Jucker et al., „Alzheimer’s disease: From immunotherapy to immunoprevention,” Cell 186, no. 20 (September 2023): 4260–4270.
Mathilde Touvier et al., „Ultra-processed foods and cardiometabolic health: Public health policies to reduce consumption cannot wait,” British Medical Journal 383 (October 2023): e075294.
Matteo Gadaleta et al., „Prediction of atrial fibrillation from at-home single-lead ECG signals without arrhythmias,” NPJ Digital Medicine 6, no. 1 (December 2023): 229.
Matthew Ahmadi et al., „Do the associations of daily steps with mortality and incident cardiovascular disease differ by sedentary time levels? A device-based cohort study,” British Journal of Sports Medicine 58, no. 5 (March 2024): 261–268.
Matthew Browning et al., „Quantifying nature: Introducing NatureScore(tm) and NatureDose(tm) as health analysis and promotion tools,” American Journal of Health Promotion 38, no. 1 (January 2024): 126–134.
Matthew Cobb et al., „What Rosalind Franklin truly con-tributed to the discovery of DNA’s structure,” Nature 616, no. 7958 (April 2023): 657–660.
Matthew G. Durrant et al., „Bridge RNAs direct programmable recombination of target and donor DNA,” Nature 630, no. 8018 (June 2024): 984–993.
Matthew Herper, „FDA approves Gardasil 9, the HPV vaccine, to prevent head-and-neck cancer,” STAT News, June 12, 2020, https://www.statnews.com/2020/06/12/fda-approves-gardasil-9-the-hpv-vaccine-to-prevent-head-and-neck-cancer/.
Matthew Leming et al., „Adversarial confound regression and un-certainty measurements to classify heterogeneous clinical MRI in Mass General Brigham,” PLoS One 18, no. 3 (March 2023): e0277572.
Matthew Lin et al., „Cancer vaccines: The next immunotherapy frontier,” Nature Cancer 3, no. 8 (August 2022): 911–926.
Matthew Park et al., „Macrophages in health and disease,” Cell 185, no. 23 (November 2022): 4259–4279.
Matthew Walker, Why We Sleep (New York: Scribner, 2018).
Matthew Yousefzadeh et al., „An aged immune system drives senescence and ageing of solid organs,” Nature 594, no. 7861 (June 2021): 100–105.
Matthias Bluher, „Metabolically healthy obesity,” Endocrine Reviews 41, no. 3 (May 2020), https://doi.org/10.1210/endrev/bnaa004.
Matthias Tschop et al., „Seeking satiety: From signals to solutions,” Science Translational Medicine 15, no. 723 (November 2023): eadh4453.
Matt Kaeberlein et al., „Rapamycin and Alzheimer’s disease: Time for a clinical trial?,” Science Translational Medicine 11, no. 476 (January 2019), https://doi.org/10.1126/sci translmed.aar4289.
Maxime Taquet et al., „The recombinant shingles vaccine is associated with lower risk of dementia,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03201-5.
Maxine Nelson et al., „The APOE-R136S mutation protects against APOE4-driven tau pathology, neurodegeneration and neuroinflammation,” Nature Neuroscience 26, no. 12 (December 2023): 2104–2121.
Max Kozlov, „Your brain expands and shrinks over time – these charts show how,” Nature 604, no. 7905 (April 2022): 230–231.
Max Kozlov, „ ‘Inflammation clock’ can reveal body’s biological age,” Nature (July 2021).
Max Tamlander et al., „Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening,” British Journal of Cancer 130, no. 4 (March 2024): 651–659.
Maxwell Strachan, „The most measured man in human history,” Vice, Janu-ary 30, 2023, https://www.vice.com/en/article/z34ay8/bryan-johnson-blueprint-aging-biotech.
McKenzie Prillaman, „Obesity drugs aren’t always forever. What happens when you quit?,” Nature News, April 16, 2024, https://www.nature.com/articles/d41586-024-01091-8.
Md Zohorul Islam et al., „Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: A systematic review and meta-analysis,” Microbiome 10, no. 1 (December 2022): 218, https://doi.org/10.1186/s40168-022-01373-1.
Meagan Chriswell et al., „Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of subdoligranulum,” Science Translational Medicine 14, no. 668 (October 2022): eabn5166.
Meagan Phelan, „Innovators who fought to unlock GLP-1 drugs for obesity awarded Mani L. Bhaumik breakthrough of the year award,” AAAS News, April 4, 2024, https://www.aaas.org/news/innovators-glp-1-obesity-bhaumik-breakthrough.
Megan Molteni, „From burst bubble to medical marvel: How lipid nanoparticles became the future of gene therapy,” STAT News, May 9, 2022, https://www.statnews.com/2022/05/09/lipid-nanoparticles-future-gene-therapy/.
Megan Molteni, „Harvard longevity scientist sparks furor with claim about reversing aging in dogs,” STAT News, March 5, 2024, https://www.statnews.com/2024/03/05/david-sinclair-harvard-longevity-scientist-reversing-aging-dogs/.
Megan Molteni, „Intellia plays down concerns about accidental germline transmission in CRISPR trial,” STAT News, August 21, 2023, https://www.statnews.com/2023/08/21/intellia-crispr-trial-concern-germline-transmission/.
Megan Molteni, „Meet the fetal surgeon forging CRISPR’s next frontier: Curing diseases in the womb,” STAT News, February 21, 2024, https://www.statnews.com/2024/02/21/fetal-surgery-tippi-mackenzie-in-utero-gene-therapy/.
Megan Molteni, „New gene therapies confront many sickle cell patients with an impossible choice: A cure or fertility,” STAT News, December 6, 2023, https://www.statnews.com/2023/12/06/sickle-cell-infertility-crispr-vertex-casgevy-bluebird/.
Megan Molteni, „Scientists find a clue to why some people have ‘Alzheimer’s brains’ but no dementia,” 2021, https://www.statnews.com/2021/11/03/scientists-find-clue-to-why-some-people-have-alzheimers-brains-but-no-dementia/.
Megan Sykes et al., „Transplanting organs from pigs to humans,” Science Immunology 4, no. 41 (November 2019): eaau6298.
Meghan Cupp et al., „Neutrophil to lymphocyte ratio and cancer prognosis: An umbrella review of systematic reviews and meta-analyses of observational studies,” BMC Medicine 18, no. 1 (November 2020): 360.
Mehreen Datoo et al., „Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years’ follow-up in children in Burkina Faso: A Phase 1/2b randomised controlled trial,” Lancet Infectious Diseases 22, no. 12 (December 2022): 1728–1736.
Meijie Jiang et al., „Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality,” Nature Cardiovascular Research 3, no. 3 (March 2024): 332–342.
Meirui An et al., „Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo,” Nature Biotechnology (January 2024), https:// doi.org/10.1038/s41587-023-02078-y.
Mei Wang et al., „Association between sleep traits and biological aging risk: A Mendelian randomization study based on 157 227 cases and 179 332 controls,” Sleep 47, no. 3 (March 2024): zsad299.
Melinda Kliegman et al., „A roadmap for affordable genetic medicines,” Nature (July 2024), https://doi.org/10.1038/s41586-024-07800-7.
Melis Colakoglu et al., „Bacteriophage prevents alcoholic liver disease,” Cell 180, no. 2 (January 2020): 218–220.
Melod Mehdipour et al., „Rejuvenation of three germ layers tissues by ex-changing old blood plasma with saline-albumin,” Aging 12, no. 10 (May 2020): 8790–819.
Melody Petersen, „Inside the plan to diagnose Alzheimer’s in people with no memory problems – and who stands to benefit,” Los Angeles Times, February 14, 2024, https://www.latimes.com/science/story/2024-02-14/inside-controversial-plan-to-diagnose-alzheimers-in-people-without-symptoms.
Mengtong Li et al., „Gut-brain circuits for fat preference,” Nature 610, no. 7933 (October 2022): 722–730.
Meng Wu et al., „Gut complement induced by the microbiota combats pathogens and spares commensals,” Cell 187, no. 4 (February 2024): 897–913 e18.
Mi Ah Han et al., „Reduction of red and processed meat intake and cancer mortality and incidence: A systematic review and meta-analysis of cohort studies,” Annals of Internal Medicine 171, no. 10 (November 2019): 711–720.
Michael Belloy et al., „Association of Klotho-vs heterozygosity with risk of Alzheimer disease in individuals who carry APOE4,” JAMA Neurology 77, no. 7 (July 2020): 849–862.
Michael Bretthauer et al., „Estimated lifetime gained with cancer screening tests: A meta-analysis of randomized clinical trials,” JAMA Internal Medicine 183, no. 11 (November 2023): 1196–203.
Michael Clark et al., „Multiple health and environmental impacts of foods,” Proceedings of the National Academy of Sciences of the USA 116, no. 46 (November 2019): 23357–3362.
Michael Conboy et al., „Heterochronic parabiosis: Historical perspective and methodological considerations for studies of aging and longevity,” Aging Cell 12, no. 3 (June 2013): 525–530.
Michael Eisenstein, „Super-speedy sequencing puts genomic diagnosis in the fast lane,” Nature 626, no. 8000 (February 2024): 915–917.
Michael Gleeson et al., „The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease,” Nature Reviews Immunology 11, no. 9 (August 2011): 607–615.
Michael Grandner et al., „The translational neuroscience of sleep: A contextual framework,” Science 374, no. 6567 (October 2021): 568–573.
Michael Haney et al., „APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia,” Nature 628, no. 8006 (April 2024): 154–161.
Michael Honigberg et al., „Cardiovascular and kidney outcomes across the glycemic spectrum: Insights from the UK Biobank,” Journal of the American College of Cardiology 78, no. 5 (August 2021): 453–464.
Michael Kessler et al., „Common and rare variant associations with clonal haematopoiesis phenotypes,” Nature 612, no. 7939 (December 2022): 301–9.
Michael Moor et al., „Predicting sepsis using deep learning across international sites: A retrospective development and validation study,” EClinicalMedicine 62 (August 2023): 102124.
Michael Noetel et al., „Effect of exercise for depression: Systematic re-view and network meta-analysis of randomised controlled trials,” British Medical Journal 384 (February 2024): e075847.
Michael Phillis, „Biden administration sets first-ever limits on ‘forever chemicals’ in drinking water,” AP News, April 10, 2024, https://apnews.com/article/forever-chemicals-pfas-pollution-epa-drinking-water-1c8804288413a73bb7b99fc866c8fa51.
Michael Rafii et al., „Detection and treatment of Alzheimer’s disease in its preclinical stage,” Nature Aging 3, no. 5 (May 2023): 520–531, https://doi.org/10.1038/s43587-023-00410-4.
Michael Schleh et al., „Metaflammation in obesity and its therapeutic targeting,” Science Translational Medicine 15, no. 723 (November 2023): eadf9382.
Michael Wainberg et al., „Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank,” PLOS Medicine 18, no. 10 (October 2021): e1003782.
Michael Wilson et al., „Actionable diagnosis of neuroleptospirosis by next-generation sequencing,” New England Journal of Medicine 370, no. 25 (June 2014): 2408–2417.
Michael Young et al., „Blood pressure effect of traffic-related air pollution: A crossover trial of in-vehicle filtration,” Annals of Internal Medicine 176, no. 12 (December 2023): 1586–1594.
Michelle Andrews, „Mammography AI can cost patients extra. Is it worth it?,” KFF Health News, January 10, 2024, https://kffhealthnews.org/news/article/artificial-intelligence-mammography-extra-cost/.
Michelle O’Donoghue et al., „Small interfering RNA to reduce lipoprotein(a) in cardiovascular disease,” New England Journal of Medicine 387, no. 20 (2022): 1855–1864.
Mijia Lu et al., „SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern,” Proceedings of the National Academy of Sciences 119, no. 35 (2022): e2110105119.
Mikael Eriksson et al., „European validation of an image-derived AI-based short-term risk model for individualized breast cancer screening—a nested case-control study,” Lancet Regional Health – Europe 37 (February 2024): 100798.
Mikael Pittet et al., „Dendritic cells as shepherds of T cell immunity in cancer,” Immunity 56, no. 10 (October 2023): 2218–2230.
Mike Nalls et al., „Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: A meta-analysis of genome-wide association studies,” Lancet Neurology 18, no. 12 (December 2019): 1091–102.
Mikhail Kosiborod et al., „Semaglutide in patients with heart failure with preserved ejection fraction and obesity,” New England Journal of Medicine 389, no. 12 (September 2023): 1069–1084.
Mikolaj Ogrodnik et al., „Guidelines for minimal information on cellular senescence experimentation in vivo,” Cell 187, no. 16 (August 2024): 4150–4175.
Milica Vukmanovic-Stejic et al., „Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation,” Journal of Allergy and Clinical Immunology 142, no. 3 (September 2018): 844–856.
Min-Woo Lee et al., „A multimodal machine learning model for predicting dementia conversion in Alzheimer’s disease,” Scientific Reports 14, no. 1 (May 2024): 12276.
Ming-Li Sun et al., „Intermittent fasting and health outcomes: An umbrella re-view of systematic reviews and meta-analyses of randomised controlled trials,” EClinicalMedicine 70 (April 2024): 102519.
Ming Chen et al., „An aberrant srebp-dependent lipogenic pro-gram promotes metastatic prostate cancer,” Nature Genetics 50, no. 2 (February 2018): 206–218.
Ming Xu et al., „Senolytics improve physical function and increase lifespan in old age,” Nature Medicine 24, no. 8 (August 2018): 1246–1256.
Minkyo Song et al., „Neutrophil-to-lymphocyte ratio and mortality in the United States general population,” Scientific Reports 11, no. 1 (January 2021): 464.
Miranda Galey et al., „3-hour genome sequencing and targeted analysis to rapidly assess genetic risk,” medRxiv (2022), https://doi.org/10.1101/2022.09.09.22279746.
Misganaw Asmamaw Mengstie et al., „Recent advancements in reducing the off-target effect of CRISPR-Cas9 genome editing,” Biologics 18 (2024): 21–28.
Mitchell Lee et al., „Antiaging diets: Separating fact from fiction,” Science 374, no. 6570 (November 2021): eabe7365.
Mitchell Murdock et al., „Insights into Alzheimer’s disease from single-cell genomic approaches,” Nature Neuroscience 26, no. 2 (February 2023): 181–195.
Mitch Leslie, „Communication breakdown,” Science News, May 23, 2024, https:// www.science.org/content/article/faulty-communication-organs-make-us-old.
Mitch Leslie, „Tumor-killing viruses score rare success in late-stage trial,” Science News, December 5, 2023, https://www.science.org/content/article/tumor-killing-viruses-score-rare-success-late-stage-trial#:~:text=The%20data%20showed%20that%20an,much%20more%20research%20is%20necessary.
Mitzi Gonzales et al., „Senolytic therapy in mild Alzheimer’s disease: A Phase 1 feasibility trial,” Nature Medicine 29, no. 10 (October 2023): 2481–2488.
MJ McPherson et al., „An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases,” Science Translational Medicine 16, no. 739 (March 2024): eadd8936.
Mohammad Kazemi et al., „Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?,” Frontiers in Immunology 13 (2022): 1018962.
Mohana Ravindranath, „How mindstrong’s rush to roll out a ‘smoke alarm’ for mental illness led to its downfall,” STAT News, February 28, 2023, https://www.statnews.com/2023/02/28/mindstrong-mental-health-technology-prediction/.
Molly McDougle et al., „Separate gut-brain circuits for fat and sugar re-inforcement combine to promote overeating,” Cell Metabolism 36, no. 2 (February 2024): 393–407 e7.
Monica Jimenez, „Only 7% of American adults have good cardiometabolic health,” Tufts University, July 5, 2022, https://now.tufts.edu/2022/07/05/only-7-american-adults-have-good-cardiometabolic-health.
Moran Amit et al., „Loss of p53 drives neuron reprogramming in head and neck cancer,” Nature 578, no. 7795 (February 2020): 449–454.
Morgan Levine, „Modeling the rate of senescence: Can estimated biological age predict mortality more accurately than chronological age?,” Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68, no. 6 (June 2013): 667–674.
Morgan Levine et al., „An epigenetic biomarker of aging for lifespan and healthspan,” Aging 10, no. 4 (April 2018): 573–591.
Morten Hansen et al., „Once-weekly semaglutide versus placebo in adults with increased fracture risk: A randomised, double-blinded, two-centre, Phase 2 trial,” EClinicalMedicine 72 (June 2024): 102624.
Morten Larsen et al., „Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms—a Danish longitudinal study,” Blood Cancer Journal 14, no. 1 (February 2024): 28.
MoTrPAC Study Group, „Temporal dynamics of the multiomic response to endurance exercise training,” Nature 629, no. 8010 (May 2024): 174–183.
Moufida Ben Nasr et al., „Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule,” Cell Metabolism 36, no. 6 (June 2024): 1302–1319.e12.
Muhammet Gulen et al., „cGAS-STING drives ageing-related inflammation and neurodegeneration,” Nature 620, no. 7973 (August 2023): 374–380.
Murielle Veniant et al., „A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and Phase 1 settings,” Nature Metabolism 6, no. 2 (February 2024): 290–303.
Mythili Shastry et al., „Rise of antibody-drug conjugates: The present and future,” American Society of Clinical Oncology Educational Book 43 (May 2023): e390094.
Nadine Hausler et al., „Association of napping with incident cardiovascular events in a prospective cohort study,” Heart 105, no. 23 (December 2019): 1793–1798.
Naixin Qian et al., „Rapid single-particle chemical imaging of nanoplastics by SRS microscopy,” Proceedings of the National Academy of Sciences of the USA 121, no. 3 (January 2024): e2300582121.
Namit Chaudhary et al., „mRNA vaccines for infectious diseases: Principles, delivery and clinical translation,” Nature Reviews Drug Discovery 20, no. 11 (November 2021): 817–838.
Naomi Allen et al., „Prospective study design and data analysis in UK Biobank,” Science Translational Medicine 16, no. 729 (January 2024): eadf4428.
Natalie Rincon et al., „Racial and ethnic disparities in human papilloma-virus (HPV) vaccine uptake among United States adults, aged 27–45 years,” Human Vaccines & Immunotherapeutics 20, no. 1 (December 2024): 2313249.
Nathalie Conrad et al., „Autoimmune diseases and cardiovascular risk: A population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK,” Lancet 400, no. 10354 (September 2022): 733–743.
Nathan Gasek et al., „Strategies for targeting senescent cells in human disease,” Nature Aging 1, no. 10 (October 2021): 870–879.
Nazanin Rajai et al., „Association between social isolation with age-gap determined by artificial intelligence-enabled electrocardiography,” JACC Advances (March 2024), https://doi.org/10.1016/j.jacadv.2024.100890.
Nazish Sayed et al., „An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging,” Nature Aging 1 (July 2021): 598–615.
Nazneen Rahman, „Realizing the promise of cancer predisposition genes,” Nature 505, no. 7483 (January 2014): 302–8.
Neha Pancholi, „Taking a bite out of cancer,” American Association for Cancer Research, updated November 2023, https://www.aacr.org/blog/2023/11/14/bites-help-immune-system-destroy-cancer-cells/.
Nehmat Houssami et al., „AI as a new paradigm for risk-based screening for breast cancer,” Nature Medicine 28, no. 1 (January 2022): 29–30.
Neil Mehta et al., „The population health benefits of a healthy lifestyle: Life expectancy increased and onset of disability delayed,” Health Affairs 36, no. 8 (August 2017). 1495–502.
Netanel Loyfer et al., „A DNA methylation atlas of normal human cell types,” Nature 613, no. 7943 (January 2023): 355–364.
Neta Rosenzweig et al., „Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03122-3.
Netta Mendelson Cohen et al., „Longitudinal machine learning uncouples healthy aging factors from chronic disease risks,” Nature Aging 4, no. 1 (January 2024): 129–144.
Neus Feliu et al., „Developing future nanomedicines,” Science 384, no. 6694 (2024): 385–386.
Niall Lennon et al., „Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations,” Nature Medicine 30, no. 2 (February 2024): 480–487.
Niall McCarthy, „Poll: U.S. smoking rate falls to historic low [infographic],” Forbes, July 26, 2018, https://www.forbes.com/sites/niallmccarthy/2018/07/26/poll-u-s-smoking-rate-falls-to-historic-low-infographic/?sh=120509803351.
Nicholas Meyer et al., „The sleep–circadian interface: A window into mental disorders,” Proceedings of the National Academy of Sciences 121, no. 9 (2024): e2214756121.
Nicholas Wilcox et al., „Cardiovascular disease and cancer: Shared risk factors and mechanisms,” Nature Reviews Cardiology (April 2024), https://doi.org/10.1038/s41569-024-01017-x.
Nicolas Barthelemy et al., „Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests,” Nature Medicine 30, no. 4 (April 2024): 1085–1095.
Nicola Strenzke, „A cure for deafness?,” Med 5, no. 4 (April 2024): 285–287.
Nicole Darricarrere et al., „Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates,” Science Translational Medicine 13, no. 583 (March 2021): eabe5449.
Nicole Koutsodendris et al., „Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits,” Nature Aging 3, no. 3 (March 2023): 275–296.
Nicole Verdun et al., „Secondary cancers after chimeric antigen receptor T-cell therapy,” New England Journal of Medicine 390, no. 7 (February 2024): 584–586.
NICUSeq Study Group et al., „Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease: A randomized clinical trial,” JAMA Pediatrics 175, no. 12 (December 1, 2021): 1218–1226.
Niels Graudal et al., „Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride,” Cochrane Database of Systematic Reviews 12, no. 12 (December 2020): CD004022.
Niels Stens et al., „Relationship of daily step counts to all-cause mortality and cardiovascular events,” Journal of the American College of Cardiology 82, no. 15 (October 2023): 1483–1494.
Nikki Campo, „Can certain foods really reduce your cancer risk?,” New York Times, November 27, 2023, https://www.nytimes.com/2023/11/27/well/eat/food-diet-cancer-risk.html.
Nina Gold et al., „Perspectives of rare disease experts on newborn genome sequencing,” JAMA Network Open 6, no. 5 (May 2023): e2312231.
Noga Or-Geva et al., „Hunger guides immunity to friend versus foe,” Nature Neuroscience 27, no. 3 (March 2024): 393–394.
Noor Abdulhameed et al., „Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease,” Alzheimer’s Research & Therapy 16, no. 1 (August 2024): 173.
Nuria Diaz et al., „Discovery of potent small-molecule inhibitors of lipoprotein(a) formation,” Nature 629, no. 8013 (May 2024): 945–950.
O. Spadaro et al., „Caloric restriction in humans reveals immunometabolic regulators of health span,” Science 375, no. 6581 (February 11, 2022): 671–677.
Odette Leiter et al., „Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice,” Nature Communications 14, no. 1 (August 2023): 4375.
Olalla Saiz-Vazquez et al., „Blood pressure and Alzheimer’s disease: A re-view of meta-analysis,” Frontiers in Neurology 13 (January 2022): 1065335.
Olga Britanova et al., „Targeted depletion of TRBV9(+) T cells as immuno-therapy in a patient with ankylosing spondylitis,” Nature Medicine 29, no. 11 (November 2023): 2731–2736.
Oliver Cameron Reddy et al., „The sleeping brain: Harnessing the power of the glymphatic system through lifestyle choices,” Brain Sciences 10, no. 11 (November 2020): 868.
Olivia Thomas et al., „Cross-reactive ebna1 immunity targets alpha-crystallin B and is associated with multiple sclerosis,” Science Advances 9, no. 20 (May 2023): eadg3032.
Olivier Fesneau et al., „An intestinal TH17 cell-derived subset can initiate cancer,” Nature Immunology (July 2024), https://doi.org/10.1038/s41590-024-01909-7.
Omar Makram et al., „Nature and mental health in urban Texas: A Nature-Score-based study,” International Journal of Environmental Research and Public Health 21, no. 2 (February 2024): 168.
Omar Mossad et al., „Microbiota-dependent increase in delta-valerobetaine alters neuronal function and is responsible for age-related cognitive decline,” Nature Aging 1, no. 12 (December 2021): 1127–1136.
Onur Eskiocak et al., „Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness,” bioRxiv, March 22, 2024, https://www.ncbi.nlm.nih.gov/pubmed/38529506.
Orianna Rosa Royle, „Bryan Johnson is being used as a human guinea pig in un-proven gene therapy injections worth $25,000 a pop in an island off Honduras,” Fortune, December 21, 2023, https://fortune.com/2023/12/21/bryan-johnson-human-guinea-pig-unproven-tests-reprogram-human-genes-follistatin-roatan-island-honduras/.
Orly Ben-Yacov et al., „Personalized postprandial glucose response-targeting diet versus Mediterranean diet for glycemic control in prediabetes,” Diabetes Care 44, no. 9 (September 2021): 1980–1991.
Oscar Junhong Luo et al., „Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty,” Nature Aging 2, no. 4 (April 2022): 348–364.
Otis Brawley et al., „Understanding the varying biological behaviors of breast and other types of cancer to avoid overdiagnosis,” Annals of Internal Medicine 176, no. 9 (September 2023): 1273–1274.
Oula Dagher et al., „Advances in cancer immunotherapies,” Cell 186, no. 8 (April 2023): 1814–1814 e1.
P. Bhattarai et al., „Rare genetic variation in fibronectin 1 (FN1) protects against apoee4 in Alzheimer’s disease,” bioRxiv (January 2, 2024), https://doi.org/10.1101/2024.01.02.573895.
P. Kent Langston et al., „Immunological regulation of skeletal muscle adaptation to exercise,” Cell Metabolism 36, no. 6 (April 2024): 1175–1183.
Pablo Guasp et al., „RNA vaccines for cancer: Principles to practice,” Cancer Cell 42, no. 7 (July 2024): 1163–1184.
Paige Porrett et al., „First clinical-grade porcine kidney xenotransplant using a human decedent model,” American Journal of Transplantation 22, no. 4 (April 2022): 1037–1053.
Pamela Ting et al., „A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction,” Science 385, no. 6704 (2024): 91–99.
Panu Luukkonen et al., „Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease,” Proceedings of the National Academy of Sciences of the USA 117, no. 13 (March 2020): 7347–7354.
Paola Sebastiani et al., „The genetics of extreme longevity: Lessons from the New England Centenarian Study,” Frontiers in Genetics 3 (November 2012): 277.
Paolo Muraro, „Resetting tolerance in autoimmune disease,” Science 380, no. 6644 (May 2023): 470–471.
Param Priya Singh et al., „The genetics of aging: A vertebrate perspective,” Cell 177, no. 1 (March 2019): 200–220.
Paresh Dandona et al., „Semaglutide in early type 1 diabetes,” New En-gland Journal of Medicine 389, no. 10 (September 2023): 958–959.
Parminder Singh et al., „Taurine deficiency as a driver of aging,” Science 380, no. 6649 (June 2023): eabn9257.
Parveen Garg et al., „Coronary artery calcium screening-data first,” JAMA Internal Medicine 183, no. 11 (November 2023): 1270–1271.
Patrick Gleeson et al., „The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis,” Science Translational Medicine 16, no. 740 (2024): eadl6149.
Patrick Ho et al., „Harnessing regulatory T cells to establish immune tolerance,” Science Translational Medicine 16, no. 738 (March 2024): eadm8859.
Paula Iso-Markku et al., „Physical activity and cognitive decline among older adults: A systematic review and meta-analysis,” JAMA Network Open 7, no. 2 (2024): e2354285-e85.
Paul Arciero et al., „Morning exercise reduces abdominal fat and blood pressure in women; evening exercise increases muscular performance in women and lowers blood pressure in men,” Frontiers in Physiology 13 (May 2022): 893783.
Paula Span, „Apparently healthy, but diagnosed with Alzheimer’s?,” New York Times, March 4, 2024, https://www.nytimes.com/2024/03/04/health/alzheimers-amyloid-diagnosis.html?searchResultPosition=1.
Paul Edison et al., „Evaluation of liraglutide in the treatment of Alzheimer’s disease,” Alzheimer’s & Dementia 17, no. S9 (December 2021): e057848.
Paul Farrell, „EBV and MS: The evidence is growing stronger,” Cell 186, no. 26 (December 2023): 5675–5676.
Paul Farrell, „Epstein-Barr virus and cancer,” Annual Review of Pathology: Mechanisms of Disease 14 (January 2019): 29–53.
Paul Glue et al., „Extended-release ketamine tablets for treatment-resistant de-pression: A randomized placebo-controlled Phase 2 trial,” Nature Medicine 30, no. 7 (July 2024): 2004–9.
Paul Ridker et al., „Antiinflammatory therapy with canakinumab for atherosclerotic disease,” New England Journal of Medicine 377, no. 12 (2017): 1119–1131.
Paul Ridker et al., „Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: Exploratory results from a randomised, double-blind, placebo-controlled trial,” Lancet 390, no. 10105 (October 2017): 1833–1842.
Paul Timmers et al., „Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging,” Nature Aging 2, no. 1 (January 2022): 19–30.
Pavel Loginovic et al., „Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis,” Nature Communications 15, no. 1 (February 2024): 1415.
Pedro Saint-Maurice et al., „Estimated number of deaths prevented through increased physical activity among US adults,” JAMA Internal Medicine 182, no. 3 (March 2022): 349–352.
Penelope Andreux et al., „The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans,” Nature Metabolism 1, no. 6 (June 2019): 595–603.
Penny Moore, „Triggering rare HIV antibodies by vaccination,” Science 378, no. 6623 (December 2022): 949–50.
Pernille Yde Nielsen et al., „The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms,” Scientific Reports 14, no. 1 (January 2024): 1196.
Peter Attia, Outlive: The Science and Art of Longevity (New York: Harmony, 2024).
Peter Boersma et al., „Prevalence of multiple chronic conditions among US adults, 2018,” Preventing Chronic Disease 17 (September 2020): E106, https://doi.org/10.5888/pcd17.200130.
Peter Eggenhuizen et al., „Smith-specific regulatory T cells halt the progression of lupus nephritis,” Nature Communications 15, no. 1 (February 2024): 899.
Peter Kelly et al., „Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): A randomised controlled trial,” Lancet 404, no. 10448 (July 2024): 125–133.
Peter Noseworthy et al., „Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: A prospective non-randomised interventional trial,” Lancet 400, no. 10359 (October 2022): 1206–1212.
Peter Turnbaugh et al., „An obesity-associated gut microbiome with increased capacity for energy harvest,” Nature 444, no. 7122 (December 2006): 1027–1031.
Petra Kukanja et al., „Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology,” Cell 187, no. 8 (April 2024): 1990–2009 e19.
Philip Landrigan, „Plastics, fossil carbon, and the heart,” New England Journal of Medicine 390, no. 10 (March 2024): 948–950.
Philipp Dettmer, Immune (New York: Penguin Random House, 2021).
Phyllis Goodman et al., „Long-term effects of finasteride on prostate cancer mortality,” New England Journal of Medicine 380, no. 4 (January 2019): 393–394.
Pieter van der Veere et al., „Predicting cognitive decline in amyloid-positive patients with mild cognitive impairment or mild dementia,” Neurology 103, no. 3 (2024): e209605.
Pradeep Natarajan, „Exceptional genetics, generalizable therapeutics, and coronary artery disease,” New England Journal of Medicine 391, no. 10 (May 29, 2024), https://doi.org/doi:10.1056/NEJMe2405647.
Prakriti Gaba et al., „Association between achieved low-density lipo-protein cholesterol levels and long-term cardiovascular and safety outcomes: An analysis of fourierole,” Circulation 147, no. 16 (April 2023): 1192–203.
Prathiyankara Shailendra et al., „Resistance training and mortality risk: A systematic review and meta-analysis,” American Journal of Preventive Medicine 63, no. 2 (August 2022): 277–285.
Priscila Slepicka et al., „Harnessing mechanisms of immune tolerance to improve outcomes in solid organ transplantation: A review,” Frontiers in Immunology 12 (June 2021): 688460.
Pu-Yang Sun et al., „Rejuvenation of peripheral immune cells attenuates Alzheimer’s disease-like pathologies and behavioral deficits in a mouse model,” Science Advances 10, no. 22 (2024): eadl1123.
Qian Li et al., „Early prediction of Alzheimer’s disease and related dementias using real-world electronic health records,” Alzheimer’s & Dementia 19, no. 8 (August 2023): 3506–3518.
Qingquan Xiao et al., „Rescue of autosomal dominant hearing loss by in vivo de-livery of mini dCas13X-derived RNA base editor,” Science Translational Medicine 14, no. 654 (July 2022): eabn0449.
Qin Xu et al., „APOE4 homozygosity is a new genetic form of Alzheimer’s disease,” Nature Medicine 30, no. 5 (May 2024): 1241–1242.
R. Grace Walton et al., „Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The masters trial,” Aging Cell 18, no. 6 (December 2019): e13039.
R. Sakaniwa et al., „Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age,” Age Ageing 51, no. 5 (May 1, 2022), https://doi.org/10.1093/ageing/afac080.
R. Waziry et al., „Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial,” Nature Aging 3, no. 3 (March 2023): 248–257.
Rachael Clark, „Listen to your gut: Antibodies against gut commensals predict type 1 diabetes onset and therapeutic responses to T cell modulation,” Science Immunology 8, no. 90 (December 2023): eadn0649-
Rachel Lawrence et al., „Circulating tumour cells for early detection of clinically relevant cancer,” Nature Reviews Clinical Oncology 20, no. 7 (July 2023): 487–500.
Rachel Sparks et al., „A unified metric of human immune health,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03092-6.
Rachel Zimmerman, „How flotation therapy may help your mental health,” Washington Post, April 4, 2024, https://www.washingtonpost.com/wellness/2024/04/04/flotation-therapy-anxiety-eating-disorders/.
Radhika Seimon et al., „Effect of weight loss via severe vs moderate energy restriction on lean mass and body composition among postmenopausal women with obesity: The tempo diet randomized clinical trial,” JAMA Network Open 2, no. 10 (October 2019): e1913733.
Rafael de Cabo et al., „Effects of intermittent fasting on health, aging, and disease,” New England Journal of Medicine 381, no. 26 (December 2019): 2541–2551.
Raffaele Marfella et al., „Microplastics and nanoplastics in atheromas and cardiovascular events,” New England Journal of Medicine 390, no. 10 (March 2024): 900–910.
RAI Bethlehem et al., „Brain charts for the human lifespan,” Nature 604, no. 7906 (April 2022): 525–533.
Ramon Estruch et al., „Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts,” New England Journal of Medicine 378, no. 25 (June 2018): e34.
Ramya Kaushik et al., „In-hospital delirium and disability and cognitive impairment after Covid-19 hospitalization,” JAMA Network Open 7, no. 7 (2024): e2419640-e40.
Ranjeny Thomas et al., „Immune tolerance of citrullinated peptides,” Nature Reviews Rheumatology 20, no. 3 (March 2024): 141–142.
Ranjith Anand et al., „Design and testing of a humanized porcine donor for xenotransplantation,” Nature 622, no. 7982 (October 2023): 393–401.
Ran Xu et al., „Integrating human activity into food environments can better predict cardiometabolic diseases in the United States,” Nature Communications 14, no. 1 (November 2023): 7326.
Raphaela Lau et al., „A synbiotic preparation (SIM01) for post-acute Covid-19 syndrome in Hong Kong (RECOVERY): A randomised, double-blind, placebo-controlled trial,” Lancet Infectious Diseases 24, no. 3 (March 2024): 256–265.
Ravi Allada et al., „Circadian mechanisms in medicine,” New England Journal of Medicine 384, no. 6 (February 2021): 550–561.
Ravindra Gupta et al., „Covid-19 vaccine breakthrough infections,” Science 374, no. 6575 (December 2021): 1561–1562.
Ray Kurzweil, „Ray Kurzweil on how AI will transform the physical world,” Economist, June 17, 2024, https://www.economist.com/by-invitation/2024/06/17/ray-kurzweil-on-how-ai-will-transform-the-physical-world
Ray Kurzweil, The Singularity Is Nearer: When We Merge with AI (New York: Penguin Random House, 2024).
Raz Bar-Ziv et al., „Glial-derived mitochondrial signals affect neuronal proteostasis and aging,” Science Advances 9, no. 41 (October 2023): eadi1411.
Rebecca Mancusi et al., „The neuroscience of cancer,” Nature 618, no. 7965 (June 2023): 467–479.
Rebecca Puhl et al., „Obesity stigma: Important considerations for public health,” American Journal of Public Health 100, no. 6 (June 2010): 1019–1028.
Rebecca Robbins et al., „Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States,” Aging (Albany, NY) 13, no. 3 (February 2021): 3254–3268.
Rebecca Siegel et al., „Cancer statistics, 2024,” CA: A Cancer Journal for Clinicians 74, no. 1 (January–February 2024): 12–49.
Rebecca Sims et al., „The multiplex model of the genetics of Alzheimer’s disease,” Nature Neuroscience 23, no. 3 (March 2020): 311–322.
Rebecca Woodruff et al., „Trends in cardiovascular disease mortality rates and excess deaths, 2010–2022,” American Journal of Preventive Medicine 66, no. 4 (April 2024): 582–589.
RE Billingham et al., „Actively acquired tolerance of foreign cells,” Nature 172, no. 4379 (October 1953): 603–6.
Rein Verbeke et al., „Innate immune mechanisms of mRNA vaccines,” Immunity 55, no. 11 (November 2022): 1993–2005.
Rema Ramakrishnan et al., „Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study,” PLOS Medicine 18, no. 1 (January 2021): e1003487.
Remi Lam et al., „Learning skillful medium-range global weather forecasting,” Science 382, no. 6677 (2023): 1416–1421.
Reza Shahbazi et al., „Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations,” Nature Materials 18, no. 10 (October 2019): 1124–1132.
Rhanderson Cardoso et al., „SGLT2 inhibitors decrease cardio-vascular death and heart failure hospitalizations in patients with heart failure: A systematic review and meta-analysis,” EClinicalMedicine 36 (June 2021): 100933.
Richard Chen et al., „Pan-cancer integrative histology-genomic analysis via multi-modal deep learning,” Cancer Cell 40, no. 8 (August 2022): 865–878 e6.
Richard Perez et al., „Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus,” Science 376, no. 6589 (April 2022): eabf1970.
Ricki Colman et al., „Caloric restriction delays disease onset and mortality in rhesus monkeys,” Science 325, no. 5937 (July 2009): 201–4.
Rik Ossenkoppele et al., „Amyloid and tau pet-positive cognitively unimpaired individuals are at high risk for future cognitive decline,” Nature Medicine 28, no. 11 (November 2022): 2381–2387.
Roberta Buono et al., „When fasting gets tough, the tough immune cells get going – or die,” Cell 178, no. 5 (August 2019): 1038–1040.
Robert Chiesa et al., „Base-edited CAR7 T cells for relapsed t-cell acute lymphoblastic leukemia,” New England Journal of Medicine 389, no. 10 (September 2023): 899–910.
Robert Horne et al., „Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning,” Nature Chemical Biology 20, no. 5 (May 2024): 634–645.
Robert Kirchdoerfer et al., „Pre-fusion structure of a human corona-virus spike protein,” Nature 531, no. 7592 (March 2016): 118–121.
Robert Kuznia, „The timetable for a coronavirus vaccine is 18 months. Experts say that’s risky,” CNN, April 1, 2020, https://www.cnn.com/2020/03/31/us/coronavirus-vaccine-timetable-concerns-experts-invs/index.html.
Robert Kwee et al., „Whole-body MRI for preventive health screening: A systematic review of the literature,” Journal of Magnetic Resonance Imaging 50, no. 5 (November 2019): 1489–503.
Robert Rosenson et al., „Zodasiran, an RNAi therapeutic targeting ANGPTL3, for mixed hyperlipidemia,” New England Journal of Medicine 391, no. 10 (May 29, 2024), https://doi.org/doi:10.1056/NEJMoa2404147.
Robin Poole et al., „Coffee consumption and health: Umbrella review of meta-analyses of multiple health outcomes,” British Medical Journal 359 (November 2017): j5024.
Rob Stein, „For the first time, gene-editing provides hints for lowering cholesterol,” Health Shots, NPR, November 12, 2023, https://www.npr.org/sections/health-shots/2023/11/12/1211672034/for-the-first-time-gene-editing-provides-hints-for-lowering-cholesterol.
Rogier W. Sanders et al., „Progress on priming HIV-1 immunity,” Science 384, no. 6697 (2024): 738–739.
Roman Reggiardo et al., „Profiling of repetitive RNA sequences in the blood plasma of patients with cancer,” Nature Biomedical Engineering 7, no. 12 (December 2023): 1627–1635.
Rongqi Zhang et al., „Sleep, physical activity, and sedentary behaviors in relation to overall cancer and site-specific cancer risk: A prospective cohort study,” iScience 27, no. 6 (June 2024): 109931.
Ron Sender et al., „The total mass, number, and distribution of immune cells in the human body,” Proceedings of the National Academy of Sciences of the USA 120, no. 44 (October 2023): e2308511120.
Ron Winslow, „Even a brain-eating amoeba can’t hide from this cutting-edge diagnosis tech,” Wall Street Journal, February 8, 2023, https:// www.wsj.com/articles/even-brain-eating-amoebas-cant-hide-from-this-cutting-edge-dna-tech-11675874957.
Rory Hills et al., „Proactive vaccination using multiviral quartet nanocages to elicit broad anti-coronavirus responses,” Nature Nanotechnology 19, no. 8 (August 2024): 1216–1223.
Roy Adams et al., „Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis,” Nature Medicine 28, no. 7 (July 2022): 1455–1460.
Ruben Lopez-Bueno et al., „Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: A systematic review with dose-response meta-analysis,” Ageing Research Reviews 82 (December 2022): 101778.
Ruilong Li et al., „Viral metagenome reveals microbial hosts and the associated antibiotic resistome on microplastics,” Nature Water 2, no. 6 (June 2024): 553–565.
Rui Qi et al., „A blood-based marker of mitochondrial DNA damage in Parkinson’s disease,” Science Translational Medicine 15, no. 711 (August 2023): eabo1557.
Ruslan Medzhitov et al., „Exploring new perspectives in immunology,” Cell 187, no. 9 (April 2024): 2079–2094.
Ruth Karron, „RSV illness in the young and the old—the beginning of the end?,” New England Journal of Medicine 388, no. 16 (April 2023): 1522–1524.
S. Liuyang et al., „Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming,” Cell Stem Cell 30, no. 4 (April 2023): 450–459.e9.
Saar Ezagouri et al., „Physiological and molecular dissection of daily variance in exercise capacity,” Cell Metabolism 30, no. 1 (July 2019): 78–91 e4.
Saba Aziz, „Are ‘Ozempic babies’ on the rise? What to know about the growing phenomenon,” GlobalNews, June 1, 2024, https://globalnews.ca/news/10536768/ozempic-babies-explained/.
Sachin Gadani et al., „The calvaria stands alone: Unique aspects of the skull bone marrow-meninges border,” Cell 186, no. 17 (August 2023): 3524–3526.
Sachin Kheterpal et al., „Digitising the prediction and management of sepsis,” Lancet 399, no. 10334 (April 2022): 1459.
Safi Khan et al., „Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: An umbrella review and evidence map,” Annals of Internal Medicine 171, no. 3 (August 2019): 190–198.
Sagar Gaikwad et al., „Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice,” Science Translational Medicine 16, no. 754 (2024): eadj5958.
Sahana Bettadapura et al., „Changes in food preferences and ingestive behaviors after glucagon-like peptide-1 analog treatment: Techniques and opportunities,” International Journal of Obesity (March 2024), https://doi.org/10.1038/s41366-024-01500-y.
Sakari Jukarainen et al., „Genetic risk factors have a substantial impact on healthy life years,” Nature Medicine 28, no. 9 (September 2022): 1893–901.
Samad Amini et al., „Prediction of Alzheimer’s disease progression within 6 years using speech: A novel approach leveraging language models,” Alzheimer’s & Dementia 20, no. 8 (August 2024): 5262–5270.
Samagya Banskota et al., „Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins,” Cell 185, no. 2 (January 20, 2022): 250–265 e16.
Sam Altman et al., „AI-driven behavior change could transform health care,” TIME, July 7, 2024, https://time.com/6994739/ai-behavior-change-health-care/.
Samantha Burnham et al., „When does Alzheimer’s disease start? Ro-bust estimates based on longitudinal aβ-amyloid-pet in three large international cohorts,” Preprints with Lancet, March 18, 2024, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4757682#:~:text=Findings%3A%20Threshold%20Aβ%2DPET%20became,2%20±%201·2%20years.
Sam Ereira et al., „Early detection of dementia with default-mode network effective connectivity,” Nature Mental Health 2, no. 7 (July 2024): 787–800.
Samuel Booth et al., „Predicting cognitive decline in Parkinson’s disease using FDG-PET-based supervised learning,” Journal of Clinical Investigation 132, no. 20 (October 2022): 1–9.
Samuele Ferrari et al., „A step toward stem cell engineering in vivo,” Science 381, no. 6656 (July 2023): 378–379.
Samuel Finlayson et al., „The clinician and dataset shift in artificial intelligence,” New England Journal of Medicine 385, no. 3 (July 2021): 283–286.
Sangita Choudhury et al., „Somatic mutations in single human cardio-myocytes reveal age-associated DNA damage and widespread oxidative genotoxicity,” Nature Aging 2, no. 8 (August 2022): 714–725.
Sanjay Rajagopalan et al., „Air pollution exposure and cardiometabolic risk,” Lancet Diabetes & Endocrinology 12, no. 3 (March 2024): 196–208.
Sanjeev Budhathoki et al., „Association of ani-mal and plant protein intake with all-cause and cause-specific mortality in a Japanese cohort,” JAMA Internal Medicine 179, no. 11 (November 2019): 1509–1518.
Saori Sakaue et al., „Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan,” Nature Medicine 26, no. 4 (April 2020): 542–548.
Sapir Golan Shekhtman et al., „Abdominal fat depots are related to lower cognitive functioning and brain volumes in middle-aged males at high Alzheimer’s risk,” Obesity (Silver Spring) 32, no. 5 (May 2024): 1009–1022.
Sara Ahadi et al., „Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock,” eLife 12 (April 2023): e82364.
Sara Ashley O’Brien, „Is glucose the new gluten? Inside the blood-sugar health craze,” January 25, 2024, https://www.wsj.com/health/wellness/glucose-goddess-method-jessie-inchauspe-cgm-ea0e3135.
Sarah Andrews et al., „An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans,” Science Translational Medicine 15, no. 692 (April 2023): eade4976.
Sarah Berry et al., „Human postprandial responses to food and potential for precision nutrition,” Nature Medicine 26, no. 6 (June 2020): 964–973.
Sarah Johnstone et al., „Epigenetic clocks, aging, and cancer,” Science 378, no. 6626 (December 2022): 1276–1277.
Sarah Zhang, „Ozempic makes you lose more than fat,” February 2, 2024, https://www.theatlantic.com/health/archive/2024/02/ozempics-muscle-loss-problem/677326/.
Sarah Zhang, „The cystic-fibrosis breakthrough that changed everything,” March 7, 2024, https://www.theatlantic.com/magazine/archive/2024/04/cystic-fibrosis-trikafta-breakthrough-treatment/677471/.
Sara Montserrat-Vazquez et al., „Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice,” NPJ Regenerative Medicine 7, no. 1 (December 2022): 78.
Sara Poletti et al., „Inflammatory mediators in major depression and bipolar disorder,” Translational Psychiatry 14, no. 1 (June 2024): 247.
Sara Reardon, „How psychedelic drugs achieve their potent health benefits,” Nature News, June 14, 2023, https://www.nature.com/articles/d41586-023-01920-2.
Sara Reardon, „How to supercharge cancer-fighting cells: Give them stem-cell skills,” Nature 628, no. 8008 (April 2024): 486.
Sara Seidelmann et al., „Dietary carbohydrate intake and mortality: A prospective cohort study and meta-analysis,” Lancet Public Health 3, no. 9 (September 2018): e419–e28.
Sara Simmonds et al., „CZ ID: A cloud-based, no-code platform enabling advanced long read metagenomic analysis,” bioRxiv (2024), https://doi.org/https://doi.org/10.1101/2024.02.29.579666.
Sara Volpe et al., „Once-weekly subcutaneous semaglutide improves fatty liver disease in patients with type 2 diabetes: A 52-week prospective real-life study,” Nutrients 14, no. 21 (November 2022), https://doi.org/10.3390/nu14214673.
Saul Villeda et al., „Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice,” Nature Medicine 20, no. 6 (June 2014): 659–663.
Saurabh Jha et al., „Upending the model of AI adoption,” Lancet 401, no. 10392 (June 2023): 1920.
Scarlett Barker et al., „MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration,” Science Translational Medicine 13, no. 618 (November 2021): eabd7695.
Scott Weichenthal et al., „How low can you go? Air pollution affects mortality at very low levels,” Science Advances 8, no. 39 (September 2022): eabo3381.
Sean McCutcheon et al., „Epigenome editing technologies for discovery and medicine,” Nature Biotechnology 42, no. 8 (August 2024): 1199–217.
Sean Wharton et al., „Daily oral GLP-1 receptor agonist orforglipron for adults with obesity,” New England Journal of Medicine 389, no. 10 (September 2023): 877–888.
Sebastiaan van Kampen et al., „CRISPR base editing lowers cholesterol in monkeys,” Nature Biotechnology 39, no. 8 (August 2021): 920–921.
Sebastian Brandhorst et al., „Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk,” Nature Communications 15, no. 1 (February 2024): 1309.
Sebastian Dohm-Hansen et al., „The ‘middle-aging’ brain,” Trends in Neurosciences 47, no. 4 (April 2024): 259–272.
Sebastian Klobuch et al., „Tumour-infiltrating lymphocyte therapy for patients with advanced-stage melanoma,” Nature Reviews Clinical Oncology 21, no. 3 (March 2024): 173–184.
Sebastian Ludyga et al., „Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals,” Nature Human Behaviour 4, no. 6 (June 2020): 603–612.
Sebastian Palmqvist et al., „Blood biomarkers to detect Alzheimer disease in primary care and secondary care,” JAMA (2024), https://doi.org/10.1001/jama.2024.13855.
Sebastian Walsh et al., „Considering challenges for the new Alzheimer’s drugs: Clinical, population, and health system perspectives,” Alzheimer’s & Dementia 20, no. 9 (September 2024): 6639–6646.
Sebastien Baur et al., „HeAR –Health acoustic representations,” arXiv (March 2024), https://doi.org/https://doi.org/10.48550/arXiv.2403.02522.
Sebastien Herzig et al., „AMPK: Guardian of metabolism and mitochondrial homeostasis,” Nature Reviews Molecular Cell Biology 19, no. 2 (February 2018): 121–135.
Sehoon Park et al., „Altered risk for cardiovascular events with changes in the metabolic syndrome status: A nationwide population-based study of approximately 10 million persons,” Annals of Internal Medicine 171, no. 12 (December 2019): 875–884.
Selim Chaib et al., „Cellular senescence and senolytics: The path to the clinic,” Nature Medicine 28, no. 8 (August 2022): 1556–1568.
Seong-Ji Han et al., „Microbiota configuration determines nutritional immune optimization,” Proceedings of the National Academy of Sciences of the USA 120, no. 49 (December 2023): e2304905120.
Seong-Young Kwon et al., „Exploiting bacteria for cancer immunotherapy,” Nature Reviews Clinical Oncology 21, no. 8 (August 2024): 569–589.
Serena Porcari et al., „Fine-tuning the gut ecosystem: The current landscape and outlook of artificial microbiome therapeutics,” Lancet Gastroenterology & Hepatology 9, no. 5 (May 2024): 460–475.
Sergio Castro-Gomez et al., „Innate immune activation in neuro-degenerative diseases,” Immunity 57, no. 4 (April 2024): 790–814.
Sergio Crespo-Garcia et al., „Therapeutic targeting of cellular senescence in diabetic macular edema: Preclinical and Phase 1 trial results,” Nature Medicine 30, no. 2 (February 2024): 443–454.
Seth Martin et al., „2024 heart disease and stroke statis-tics: A report of US and global data from the American heart association,” Circulation 149, no. 8 (February 2024): e347–e913.
Seung-Jung Park et al., „Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (prevent): A multicentre, open-label, randomised controlled trial,” Lancet 403, no. 10438 (May 2024): 1753–1765.
Seungjin Ryu et al., „Genetic signature of human longevity in PKC and NF-kappaB signaling,” Aging Cell 20, no. 7 (July 2021): e13362.
Severine Sabia et al., „Association of sleep duration in middle and old age with incidence of dementia,” Nature Communications 12, no. 1 (April 2021): 2289.
Seyhan Yazar et al., „Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease,” Science 376, no. 6589 (April 2022): eabf3041.
Shafqat Ahmad et al., „Mediterranean diet adherence and risk of all-cause mortality in women,” JAMA Network Open 7, no. 5 (May 1, 2024): e2414322.
Shahad Alsaiari et al., „Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer,” Science Advances 10, no. 10 (March 2024): eadj6380.
Shanu Modi et al., „Trastuzumab deruxtecan in previously treated her2-low advanced breast cancer,” New England Journal of Medicine 387, no. 1 (July 2022): 9–20.
Sharon Lerner, „How 3M discovered, then concealed, the dangers of forever chemicals,” New Yorker, May 20, 2024, https://www.newyorker.com/magazine/2024/05/27/3m-forever-chemicals-pfas-pfos-toxic.
Sharon Peacock, „Health care: Bring microbial sequencing to hospitals,” Nature 509, no. 7502 (May 2014): 557–559.
Sharon Plon et al., „Ten years of incidental, secondary, and actionable findings,” New England Journal of Medicine 389, no. 19 (November 2023): 1813–1814.
Sharon Sha et al., „Safety, tolerability, and feasibility of young plasma in-fusion in the plasma for Alzheimer symptom amelioration study: A randomized clinical trial,” JAMA Neurology 76, no. 1 (January 2019): 35–40.
Sharyb Alfonsi et al., „Experimental ultrasound treatment targeting brains in trials to help those with Alzheimer’s, drug addiction,” 60 Minutes Overtime, CBS News, January 14, 2024, https://www.cbsnews.com/news/ultrasound-treatment-alzheimers-drug-addiction-patients-60-minutes/.
Shenghan Lou et al., „Artificial intelligence for colorectal neoplasia detection during colonoscopy: A systematic review and meta-analysis of randomized clinical trials,” EClinicalMedicine 66 (December 2023): 102341.
Shenyang Huang et al., „Hippocampal functions modulate transfer-appropriate cortical representations supporting subsequent memory,” Journal of Neuroscience 44, no. 1 (January 2024): e1135232023.
Sherry Murphy et al., Deaths: Final data for 2010, Vol. 61, National Center for Health Statistics (Hyattsville, MD, May 2013), 1–99.
Shifu Pang et al., „Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures,” Nature Aging 3, no. 4 (April 2023): 436–449.
Shimoli Barot et al., „Distinct intratumoral microbiome of young-onset and average-onset colorectal cancer,” EBioMedicine 100 (February 2024): 104980.
Shirley Wang, „Can mental health chatbots help with anxiety and depression?,” Wall Street Journal, May 12, 2024, https://www.wsj.com/health/wellness/ai-chatbots-mental-health-5184eca2.
Shirui Dai et al., „Chronic stress promotes cancer development,” Frontiers in Oncology 10 (August 2020): 1492.
Shivani Arora et al., „Invariant natural killer T cells coordinate removal of senescent cells,” Med 2, no. 8 (August 2021): 938–950.
Shogo Sato et al., „Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis,” Cell Metabolism 30, no. 1 (July 2019): 92–110 e4.
Shrey Grover et al., „Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation,” Nature Neuroscience 25, no. 9 (September 2022): 1237–1246.
Shuangxia Ren et al., „An interpretable deep learning framework for genome-informed precision oncology,” Nature Machine Intelligence (July 2024), https://doi.org/10.1038/s42256-024-00866-y.
Shunsuke Miyauchi et al., „Periodontal treatment during the blanking period improves the outcome of atrial fibrillation ablation,” Journal of the American Heart Association 13, no. 8 (April 2024): e033740.
Siddhartha Jaiswal et al., „Clonal hematopoiesis in human aging and disease,” Science 366, no. 6465 (November 2019): eaan4673.
Siddhartha Sharma et al., „Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells,” Science Translational Medicine 15, no. 703 (July 2023): eade3614.
Siegfried Wagner et al., „Retinal optical coherence tomography features associated with incident and prevalent Parkinson disease,” Neurology 101, no. 16 (October 2023): e1581–e93.
Silvia Di Federico et al., „Alcohol intake and blood pressure levels: A dose-response meta-analysis of nonexperimental cohort studies,” Hypertension 80, no. 10 (October 2023): 1961–1969.
Silvia Sookoian et al., „Resmetirom for treatment of MASH,” Cell 187, no. 12 (June 2024): 2897–2897 e1.
Silvia Stringhini et al., „Socioeconomic status and the 25 x 25 risk factors as determinants of premature mortality: A multicohort study and meta-analysis of 1.7 million men and women,” Lancet 389, no. 10075 (March 2017): 1229–1237.
Simon BK Jensen et al., „Bone health after exercise alone, GLP-1 receptor agonist treatment, or combination treatment: A secondary analysis of a randomized clinical trial,” JAMA Network Open 7, no. 6 (2024): e2416775-e75.
Simone Pecetta et al., „mRNA, the beginning of a new influenza vaccine game,” Proceedings of the National Academy of Sciences of the USA 119, no. 50 (December 2022): e2217533119.
Simon Garaudé et al., „Selective haematological cancer eradication with preserved haematopoiesis,” Nature 630, no. 8017 (June 2024): 728–735.
Simon Goldberg et al., „Mobile phone-based interventions for mental health: A systematic meta-review of 14 meta-analyses of randomized controlled trials,” PLOS Digital Health 1, no. 1 (January 2022): e0000002.
Simon H Ye et al., „Benchmarking metagenomics tools for taxonomic classification,” Cell 178, no. 4 (August 2019): 779–794.
Simon Stacey et al., „Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis,” Nature Genetics 55, no. 12 (December 2023): 2149–2159.
Sina Kianersi et al., „Association between accelerometer-measured irregular sleep duration and type 2 diabetes risk: A prospective cohort study in the UK Biobank,” Diabetes Care (July 2024), https://doi.org/10.2337/dc24-0213.
Sinisa Bratulic et al., „Noninvasive detection of any-stage cancer using free glycosaminoglycans,” Proceedings of the National Academy of Sciences of the USA 119, no. 50 (December 2022): e2115328119.
Sisi Chen et al., „Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells,” Cell Discovery 8, no. 1 (August 2022): 80.
Slobodan Culina et al., „Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors,” Science Immunology 3, no. 20 (February 2018): eaao4013, https://doi.org/10.1126/sciimmunol.aao4013.
Smriti Mallapaty, „Cutting-edge CAR-T cancer therapy is now made in India – at one-tenth the cost,” Nature 627, no. 8005 (March 2024): 709–710.
Sneha Goenka et al., „Accelerated identification of disease-causing variants with ultra-rapid nanopore genome sequencing,” Nature Biotechnology 40, no. 7 (July 2022): 1035–1041.
Sofia Lotti et al., „Circadian rhythms, gut microbiota, and diet: Possible implications for health,” Nutrition, Metabolism & Cardiovascular Diseases 33, no. 8 (August 2023): 1490–500.
Sofia Moutinho, „Clinical trials assess a precision-medicine approach to cancer screening,” Nature Medicine 29, no. 7 (July 2023): 1587–1590.
Solal Chauquet et al., „Exercise rejuvenates microglia and reverses T cell ac-cumulation in the aged female mouse brain,” Aging Cell 23, no. 7 (July 2024): e14172.
Sonja Fernbach et al., „Loss of tolerance precedes triggering and lifelong persistence of pathogenic type in interferon autoantibodies,” Journal of Experimental Medicine 221, no. 9 (2024), https://doi.org/10.1084/jem.20240365.
Soo Lim, „A new international journal targeting the pathophysiology and treatment of obesity and metabolic syndrome,” Journal of Obesity & Metabolic Syndrome 26, no. 2 (June 2017): 81–83.
Stacy Castner et al., „Longevity factor klotho enhances cognition in aged nonhuman primates,” Nature Aging 3, no. 8 (August 2023): 931–937.
Stanislav Dikiy et al., „Principles of regulatory T cell function,” Immunity 56, no. 2 (February 2023): 240–255.
Stefan Gustafsson et al., „Markers of imminent myocardial infarction,” Nature Cardiovascular Research 3, no. 2 (February 2024): 130–139.
Stefanie Gerstberger et al., „Metastasis,” Cell 186, no. 8 (April 2023): 1564–1579.
Stefanie Grabrucker et al., „Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis,” Brain 146, no. 12 (December 2023): 4916–4934.
Stefan Krause et al., „The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases,” Cell Reports Medicine 5, no. 6 (June 2024): 101581
Stefan Nidorf et al., „Colchicine in patients with chronic coronary disease,” New England Journal of Medicine 383, no. 19 (November 2020): 1838–1847.
Steffanie Strathdee et al., „Phage therapy: From biological mechanisms to future directions,” Cell 186, no. 1 (January 2023): 17–31.
Stephanie Armour et al., „Employers are offering a new worker benefit: Wellness chatbots,” Wall Street Journal, December 27, 2023, https://www.wsj.com/tech/ai/employers-are-offering-a-new-worker-benefit-wellness-chatbots-cc298b20.
Stephanie Nguengang Wakap et al., „Estimating cumulative point prevalence of rare diseases: Analysis of the orphanet database,” European Journal of Human Genetics 28, no. 2 (February 2020): 165–173.
Stephen Bagley et al., „Intrathecal bivalent CAR T cells targeting EGFR and il13rα2 in recurrent glioblastoma: Phase 1 trial interim results,” Nature Medicine 30, no. 5 (May 2024): 1320–1329.
Stephen Cristiano et al., „Genome-wide cell-free DNA fragmentation in patients with cancer,” Nature 570, no. 7761 (June 2019): 385–389.
Stephen Nicholls et al., „Muvalaplin, an oral small molecule inhibitor of lipoprotein(a) formation: A randomized clinical trial,” JAMA 330, no. 11 (September 2023): 1042–1053.
Stephen Salloway et al., „A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease,” Nature Medicine 27, no. 7 (July 2021): 1187–1196.
Steve Horvath, „DNA methylation age of human tissues and cell types,” Genome Biology 14, no. 10 (October 2013): R115.
Steve Horvath et al., „Digitising the ageing process with epigenetic clocks,” Lancet 404, no. 10451 (August 2024): 423.
Steve Horvath et al., „Reversal of biological age in multiple rat organs by young porcine plasma fraction,” bioRxiv (August 2023): 2023.08.06.552148.
Steven Austad, „Animal size, metabolic rate, and survival, among and within species,” in The Comparative Biology of Aging, ed. Norman Wolf (Netherlands: Springer, 2010), 24–41.
Steven Austad et al., „How ubiquitous is aging in vertebrates?,” Science 376, no. 6600 (June 2022): 1384–1385.
Steven Marso et al., „Liraglutide and cardiovascular outcomes in type 2 diabetes,” New England Journal of Medicine 375, no. 4 (July 2016): 311–322.
Steven Moore et al., „Leisure time physical activity of moderate to vigorous intensity and mortality: A large pooled cohort analysis,” PLOS Medicine 9, no. 11 (2012): e1001335.
Steven Nissen et al., „Bempedoic acid and cardiovascular outcomes in statin-intolerant patients,” New England Journal of Medicine 388, no. 15 (April 2023): 1353–1364.
Steven Nissen et al., „Lepodisiran, an extended-duration short interfering RNA targeting lipoprotein(a): A randomized dose-ascending clinical trial,” JAMA 330, no. 21 (December 2023): 2075–2083.
Steven Ross Johnson, „WHO report: Worldwide cancer cases to double by 2050,” US News & World Report, February 1, 2024, https://www.usnews.com/news/best-countries/articles/2024-02-01/who-report-number-of-worldwide-cancer-cases-to-double-by-2050#:~:text=As%20a%20result%2C%20the%20number,to%209.7%20million%20in%20
Steven Woloshin et al., „The new USPSTF mammography recommendations—a dissenting view,” New England Journal of Medicine 389, no. 12 (September 2023): 1061–1064.
Stuart Thompson, „How long will a vaccine really take?,” New York Times, April 30, 2020.
Stuti Jaiswal et al., „Using new technologies and wearables for characterizing sleep in population-based studies,” Current Sleep Medicine Reports 10 (January 2024): 82–92.
Su-Jeong Kim et al., „A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease,” Molecular Psychiatry 29, no. 2 (February 2024): 505–517.
Subigya Nepal et al., „Moodcapture: Depression detection using in-the-wild smart-phone images,” arXiv, February 25, 2024, https://arxiv.org/abs/2402.16182.
Sudarshini Ramanathan et al., „Origins and immunopathogenesis of autoimmune central nervous system disorders,” Nature Reviews Neurology 19, no. 3 (March 2023): 172–190.
Sugai Liang et al., „Digital cognitive behavior therapy for insomnia improving sleep quality: A real-world study,” BMC Psychiatry 22, no. 1 (December 2022): 768.
Sultana Monira Hussain et al., „Association of plasma high-density lipoprotein cholesterol level with risk of incident dementia: A cohort study of healthy older adults,” Lan-cet Regional Health – Western Pacific 43 (February 2024): 100963.
Suman Paul et al., „Cancer therapy with antibodies,” Nature Reviews Cancer 24, no. 6 (June 2024): 399–426.
Sung-Ik Cho et al., „Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases,” Cell 185, no. 10 (May 2022): 1764–1776 e12.
Sung-Jen Wei et al., „Ketogenic diet induces p53-dependent cellular senescence in multiple organs,” Science Advances 10, no. 20 (May 2024): eado1463.
Sunil Ahuja et al., „Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection,” Nature Communications 14, no. 1 (June 2023): 3286.
Suraj Pai et al., „Foundation model for cancer imaging biomarkers,” Nature Machine Intelligence 6, no. 3 (2024): 354–367.
Susan Foy et al., „Non-viral precision T cell receptor replacement for personalized cell therapy,” Nature 615, no. 7953 (March 2023): 687–696.
Susan Gapstur et al., „The IARC perspective on alcohol reduction or cessation and cancer risk,” New England Journal of Medicine 389, no. 26 (December 28, 2023): 2486–2494.
Susan Howlett et al., „The degree of frailty as a translational measure of health in aging,” Nature Aging 1, no. 8 (August 2021): 651–665.
Susan Silberman, „The inequities in the cost of chronic disease: Why it matters for older adults,” National Council on Aging, April 21, 2022, https://www.ncoa.org/article/the-inequities-in-the-cost-of-chronic-disease-why-it-matters-for-older-adults.
Sven Bocklandt et al., „Epigenetic predictor of age,” PLoS One 6, no. 6 (June 2011): e14821.
Szymon Fedor et al., „Wearable technology in clinical practice for depressive disorder,” New England Journal of Medicine 389, no. 26 (December 2023): 2457–2466.
Tae Hyun Kim et al., „Blood culture-free ultra-rapid antimicrobial susceptibility testing,” Nature (July 2024), https://doi.org/10.1038/s41586-024-07725-1.
Tal Iram et al., „Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17,” Nature 605, no. 7910 (May 2022): 509–515.
Tanya Jain et al., „Gut microbes modulate neurodegeneration,” Science 379, no. 6628 (January 2023): 142–143.
Tapash Jay Sarkar et al., „Transient non-integrative expression of nu-clear reprogramming factors promotes multifaceted amelioration of aging in human cells,” Nature Communications 11, no. 1 (March 2020): 1545.
Tara Hogenson et al., „Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers,” JCI Insight 7, no. 22 (November 2022), https://doi.org/10.1172/jci.insight.158060.
Tarini Shankar Ghosh et al., „Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: The NU-AGE 1-year dietary intervention across five European countries,” Gut 69, no. 7 (July 2020): 1218–1228.
Tatiana Yankova et al., „Three month heterochronic parabiosis has a deleterious effect on the lifespan of young animals, without a positive effect for old animals,” Rejuvenation Research 25, no. 4 (August 2022): 191–199.
Tatsuya Daikoku et al., „Bodily maps of uncertainty and surprise in musical chord progression and the underlying emotional response,” iScience 27, no. 4 (April 2024): 109498.
Taylor Stevenson et al., „ ‘Bloody’ good factors for keeping the brain young,” Immunity 56, no. 10 (October 2023): 2185–2187.
Ted Alcorn, „Should alcoholic beverages have cancer warning labels?,” New York Times, April 9, 2024, https://www.nytimes.com/2024/04/09/health/alcohol-cancer-warning.html.
Ted Alcorn, „U.S. lags behind other countries in hepatitis-C treatment,” New York Times, April 28, 2024, https://www.nytimes.com/2024/04/28/health/hepatitis-c.html.
Teddy Amenabar, „Why Viagra has been linked with better brain health,” Washington Post, February 22, 2024, https://www.washingtonpost.com/wellness/2024/02/22/viagra-alzheimers-dementia-erectile-dysfunction/.
Tengfei Ren et al., „Exercise activates interferon response of the liver via gpld1 to enhance antiviral innate immunity,” Science Advances 10, no. 22 (May 2024): eadk5011.
Themoula Charalampous et al., „Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial trans-mission on expanded COVID-19 intensive care units,” Genome Medicine 13, no. 1 (November 2021): 182.
Theogene Habineza et al., „End-to-end risk prediction of atrial fibrillation from the 12-lead ECG by deep neural networks,” Journal of Electrocardiology 81 (November–December 2023): 193–200.
Thomas Austin et al., „A plasma protein-based risk score to predict hip fractures,” Nature Aging 4, no. 8 (August 2024): 1064–1075.
Thomas Battaglia et al., „A pan-cancer analysis of the microbiome in meta-static cancer,” Cell 187, no. 9 (April 2024): 2324–2335.e19.
Thomas Cheever et al., „NIH/Kennedy Center workshop on music and the brain: Finding harmony,” Neuron 97, no. 6 (March 2018): 1214–1218.
Thomas Imperiale et al., „Next-generation multitarget stool DNA test for colorectal cancer screening,” New England Journal of Medicine 390, no. 11 (2024): 984–993.
Tian Ge et al., „Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations,” Genome Medicine 14, no. 1 (June 2022): 70.
Tiange Wang et al., „Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk,” Nature Medicine 30, no. 6 (June 2024): 1722–1731.
Tian Mi et al., „Conserved epigenetic hallmarks of T cell aging during immunity and malignancy,” Nature Aging (June 2024), https://doi.org/10.1038/s43587-024-00649-5.
Tiia Ngandu et al., „A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial,” Lancet 385, no. 9984 (June 2015): 2255–2263.
Tim Konig et al., „Mitochondrial-derived vesicles in metabolism, disease, and aging,” Cell Metabolism 36, no. 1 (January 2024): 21–35.
Timon Adolph et al., „Western diets and chronic diseases,” Nature Medicine (July 2024), https://doi.org/10.1038/s41591-024-03165-6.
Timothy O’Brien et al., „Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon,” American Journal of Human Genetics 110, no. 8 (August 2023): 1249–1265.
Timothy Rhoads et al., „Caloric restriction has a new player,” Science 375, no. 6581 (February 2022): 620–621.
Timothy Wiemken et al., „Assisting the infection preventionist: Use of artificial intelligence for health care-associated infection surveillance,” American Journal of Infection Control 52, no. 6 (June 2024): 625–629.
Tim Palmer et al., „Invasive cervical cancer incidence following bivalent human papillomavirus vaccination: A population-based observational study of age at immunization, dose, and deprivation,” Journal of the National Cancer Institute (January 2024): djad263.
Ting Huai Shi et al., „The influence of metabolic syndrome in predicting mortality risk among US adults: Importance of metabolic syndrome even in adults with normal weight,” Preventing Chronic Disease 17 (May 2020): E36.
Tingting Wang et al., „A lipidomic based metabolic age score captures cardiometabolic risk independent of chronological age,” EBioMedicine 105 (July 2024): 105199.
Tingting Wang et al., „Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites,” EBioMedicine 103 (May 2024): 105118.
Todd Golde et al., „Immunotherapies for Alzheimer’s disease,” Science 382, no. 6676 (December 2023): 1242–1244.
Tomasz Wilmanski et al., „Gut microbiome pattern reflects healthy ageing and predicts survival in humans,” Nature Metabolism 3, no. 2 (February 2021): 274–286.
Tom Foltynie et al., „Medical, surgical, and physical treatments for Parkinson’s disease,” Lancet 403, no. 10423 (January 2024): 305–324.
Tomi Lazarov et al., „Physiology and diseases of tissue-resident macrophages,” Nature 618, no. 7966 (June 2023): 698–707.
Tomoaki Hishida et al., „In vivo partial cellular reprogramming enhances liver plasticity and regeneration,” Cell Reports 39, no. 4 (April 2022): 110730.
Tomoaki Murakami et al., „Rejuvenation of diabetic macular edema with senolytic therapy,” Nature Medicine 30, no. 2 (February 2024): 346–347.
Tomomi Nishimura et al., „Evolutionary histories of breast cancer and related clones,” Nature 620, no. 7974 (August 2023): 607–614.
Tsion Aberra et al., „The association between triglycerides and incident cardiovascular disease: What is ‘optimal’?,” Journal of Clinical Lipidology 14, no. 4 (July–August 2020): 438–447 e3.
Tyler Bussian et al., „Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline,” Nature 562, no. 7728 (October 2018): 578–582.
Tyler Cook et al., „Dual-action obesity drug rewires brain circuits for appetite,” Nature News & Views, May 15, 2024, https://www.nature.com/articles/d41586-024-01352-6.
Tyler Hyungtaek Rim et al., „Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs,” Lancet Digital Health 3, no. 5 (May 2021): e306–e16.
U.S. Food & Drug Administration, „FDA investigating serious risk of T-cell malignancy following BCMA-directed or CD19-directed autologous chimeric antigen receptor (CAR) T cell immunotherapies,” November 28, 2023, https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/fda-investigating-serious-risk-t-cell-malignancy-following-bcma-directed-or-cd19-directed-autologous.
Ugur Uslu et al., „CAR T cell combination therapies to treat cancer,” Cancer Cell (July 2024), https://doi.org/10.1016/j.ccell.2024.07.002.
Ulf Ekelund et al., „Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women,” Lancet 388, no. 10051 (September 2016): 1302–1310.
Unai Galicia-Garcia et al., „Statin treatment-induced development of type 2 diabetes: From clinical evidence to mechanistic insights,” International Journal of Molecular Sciences 21, no. 13 (July 2020), https://doi.org/10.3390/ijms21134725.
Urs Morbe et al., „Human gut-associated lymphoid tissues (GALT); diversity, structure, and function,” Mucosal Immunology 14, no. 4 (July 2021): 793–802.
Urszula Wasko et al., „Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer,” Nature 629, no. 8013 (May 2024): 927–936.
US Preventive Services Task Force, „Aspirin use to prevent cardiovascular disease: US preventive services task force recommendation statement,” JAMA 327, no. 16 (April 2022): 1577–1584.
V. White et al., „Online psychological interventions to reduce symptoms of depression, anxiety, and general distress in those with chronic health conditions: A systematic review and meta-analysis of randomized controlled trials,” Psychological Medicine 52, no. 3 (February 2022): 548–573.
Valentina Lo Sardo et al., „Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing,” Cell 175, no. 7 (December 2018): 1796–810 e20.
Valter Longo et al., „Nutrition, longevity and disease: From molecular mechanisms to interventions,” Cell 185, no. 9 (April 2022): 1455–1470.
Valur Emilsson et al., „Predicting health and life span with the deep plasma proteome,” Nature Medicine 25, no. 12 (December 2019): 1815–1816.
Vanessa Frodermann et al., „Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells,” Nature Medicine 25, no. 11 (November 2019): 1761–1771.
Varun Bhave et al., „Associations between ultra-processed food consumption and adverse brain health outcomes,” Neurology 102, no. 11 (June 2024): e209432.
Varun Dwaraka et al., „Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: Insights from the twins nutrition study (twins),” BMC Medicine 22, no. 1 (July 2024): 301.
Varun Venkataramani et al., „Glutamatergic synaptic input to glioma cells drives brain tumour progression,” Nature 573, no. 7775 (September 2019): 532–538.
Vasanti Malik et al., „Long-term consumption of sugar-sweetened and artificially sweetened beverages and risk of mortality in US adults,” Circulation 139, no. 18 (April 2019): 2113–2125.
Vasiliki Dimitrakopoulou et al., „Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study,” British Medical Journal 359 (October 2017): j4761.
Vasiliki Pavlou et al., „Effect of time-restricted eating on weight loss in adults with type 2 diabetes: A randomized clinical trial,” JAMA Network Open 6, no. 10 (October 2023): e2339337.
Venki Ramakrishnan, „Why we die: The new science of aging and the quest for immortality,” Amazon, accessed June 26, 2024, https://www.amazon.com/Why-We-Die-Science-Immortality/dp/0063113279.
Vera Gorbunova et al., „The role of retrotransposable elements in ageing and age-associated diseases,” Nature 596, no. 7870 (August 2021): 43–53.
Verena Link et al., „Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans,” Nature Medicine 30, no. 2 (February 2024): 560–572.
Veronica Li et al., „An exercise-inducible metabolite that suppresses feeding and obesity,” Nature 606, no. 7915 (June 2022): 785–790.
Veronique Bouvard et al., „Carcinogenicity of consumption of red and processed meat,” Lancet Oncology 16, no. 16 (December 2015): 1599–600.
Victoria Moiseeva et al., „Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration,” Nature 613, no. 7942 (January 2023): 169–178.
Victor Zhong et al., „Associations of processed meat, unprocessed red meat, poultry, or fish intake with incident cardiovascular disease and all-cause mortality,” JAMA Internal Medicine 180, no. 4 (April 2020): 503–512.
Vijayendra Dasari et al., Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice,” Nature Communications 14, no. 1 (August 2023): 4371.
Vijay Sankaran et al., „Cellular barcoding to decipher clonal dynamics in disease,” Science 378, no. 6616 (October 2022): eabm5874.
Ville Pimenoff et al., „Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts,” Cell Host Microbe 31, no. 11 (November 2023): 1921–1929 e3.
Vilma Urbonaviciute et al., „Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis,” Proceedings of the National Academy of Sciences of the USA 120, no. 25 (June 2023): e2218668120.
Vivek Murthy, Together: The Healing Power of Human Connection in a Sometimes Lonely World (New York: Harper Audio, 2020), audiobook.
Viviane Callier, „Cells across the body talk to each other about aging,” Quanta Magazine, January 8, 2024, https://www.quantamagazine.org/cells-across-the-body-talk-to-each-other-about-aging-20240108/.
Vlado Perkovic et al., „Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes,” New England Journal of Medicine (May 2024), https://doi.org/10.1056/NEJMoa2403347.
Wanchun Xu et al., „Benefits and risks associated with statin therapy for primary prevention in old and very old adults: Real-world evidence from a target trial emulation study,” Annals of Internal Medicine 177, no. 6 (June 2024): 701–710.
Wassilios Meissner et al., „Trial of lixisenatide in early Parkinson’s disease,” New England Journal of Medicine 390, no. 13 (April 2024): 1176–1185.
Wayne Gao et al., „Occupational sitting time, leisure physical activity, and all-cause and cardiovascular disease mortality,” JAMA Network Open 7, no. 1 (January 2024): e2350680.
Wei Gu et al., „Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids,” Nature Medicine 27, no. 1 (January 2021): 115–124.
Wei Liu et al., „An improved genome-wide polygenic score model for predicting the risk of type 2 diabetes,” Frontiers in Genetics 12 (February 2021): 632385.
Wei Qiu et al., „ExplaiNAble BioLogical Age (ENABL Age): An artificial intelligence framework for interpretable biological age,” Lancet Healthy Longevity 4, no. 12 (December 2023): e711–e23,
Wendy Shoop et al., „Mitochondrial gene editing,” Nature Reviews Methods Primers 3 (March 2023).
Wen Grace Chen et al., „Music and brain circuitry: Strategies for strengthening evidence-based research for music-based interventions,” Journal of Neuroscience 42, no. 45 (November 2022): 8498–507.
Wenwen Gao et al., „Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity,” Nature Metabolism 5, no. 10 (October 2023): 1673–1684.
WHO International Agency for Research on Cancer, „Global cancer burden growing, amidst mounting need for services,” 2024, https://www.iarc.who.int/wp-content/uploads/2024/02/pr345_E.pdf.
Wilbert Vermeij et al., „Base editor repairs mutation found in the premature-ageing syndrome progeria,” Nature 589, no. 7843 (January 2021): 522–524.
Willemijn Jansen et al., „Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis,” JAMA 313, no. 19 (May 2015): 1924–1938.
William Hill et al., „Lung adenocarcinoma promotion by air pollutants,” Nature 616, no. 7955 (April 2023): 159–167.
William Lotter et al., „Robust breast cancer detection in mammography and digital breast tomosynthesis using an annotation-efficient deep learning approach,” Nature Medicine 27, no. 2 (February 2021): 244–249.
William Wang et al., „Association of semaglutide with tobacco use disorder in patients with type 2 diabetes: Target trial emulation using real-world data,” Annals of Internal Medicine (July 2024), https://doi.org/10.7326/m23-2718.
William Wang et al., „Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population,” Nature Communications 15, no. 1 (May 2024): 4548.
Wing Kwok et al., „Leisure-time physical activity and falls with and without injuries among older adult women,” JAMA Network Open 7, no. 1 (January 2024): e2354036.
Winston Liu et al., „The neural basis of sugar preference,” Nature Reviews Neuroscience 23, no. 10 (October 2022): 584–595.
WJ Strittmatter et al., „Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease,” Proceedings of the National Academy of Sciences of the USA 90, no. 17 (September 1993): 8098–102.
Wolfgang Schleicher et al., „CHIP: A clonal odyssey of the bone marrow niche,” Journal of Clinical Investigation 134, no. 15 (August 2024): 1–11.
X. Gao et al., „Epigenetics in Alzheimer’s disease,” Frontiers in Aging Neuroscience 14 (2022): 911635.
X. Wang et al., „Allogeneic cd19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis,” Cell (July 9, 2024), https://doi.org/10.1016/j.cell.2024.06.027.
Xia Gao et al., „Dietary methionine influences therapy in mouse cancer models and alters human metabolism,” Nature 572, no. 7769 (August 2019): 397–401.
Xianghui Zhang et al., „Effect of a salt substitute on incidence of hypertension and hypotension among normotensive adults,” Journal of the American College of Cardiology 83, no. 7 (February 2024): 711–722.
Xiangyu Zhang et al., „Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk,” Nature Metabolism 6, no. 2 (February 2024): 359–377.
Xiao Dong et al., „Evidence for a limit to human lifespan,” Nature 538, no. 7624 (October 2016): 257–259.
Xiaojuan He et al., „Single-cell omics in ageing: A young and growing field,” Nature Metabolism 2, no. 4 (April 2020): 293–302.
Xiaoran Liu et al., „Changes in nut consumption influence long-term weight change in US men and women,” BMJ Nutrition, Prevention & Health 2, no. 2 (September 2019): 90–99.
Xiaorui Chen et al., „Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism,” Nature Aging (April 2024), https://doi.org/10.1038/s43587-024-00612-4.
Xiaosong Liu et al., „Yamanaka factors critically regulate the develop-mental signaling network in mouse embryonic stem cells,” Cell Research 18, no. 12 (December 2008): 1177–1189.
Xiaotao Zhang et al., „Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: Insights from the BE GONE trial,” EBio-Medicine 98 (December 2023): 104873.
Xiao Tong Teong et al., „Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: A randomized controlled trial,” Nature Medicine 29, no. 4 (April 2023): 963–972.
Xiaoyan Cai et al., „Association between prediabetes and risk of all cause mortality and cardiovascular disease: Updated meta-analysis,” British Medical Journal 370 (July 2020): m2297.
Xiaoying Chen et al., „Emerging roles of innate and adaptive immunity in Alzheimer’s disease,” Immunity 55, no. 12 (December 2022): 2236–2254.
Xinyu Zhou et al., „Comparison of microbial community and metabolites in four stomach compartments of myostatin-gene-edited and non-edited cattle,” Frontiers in Micro-biology 13 (March 2022): 844962.
Xin Zhang et al., „The impact of exposure to air pollution on cognitive performance,” Proceedings of the National Academy of Sciences of the USA 115, no. 37 (September 2018): 9193–9197.
Xuan-Mai Nguyen et al., „Impact of 8 lifestyle factors on mortality and life expectancy among United States veterans: The million veteran program,” American Journal of Clinical Nutrition 119, no. 1 (January 2024): 127–135.
Xue-Yan He et al., „Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment,” Cancer Cell 42, no. 3 (March 2024): 474–486 e12.
Xue Hao et al., „TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation,” Nature Aging 4, no. 2 (February 2024): 185–197.
Xuesong Wang et al., „mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models,” Science Immunology 9, no. 95 (2024): eadn0622.
Yafeng Wang et al., „Association of physical activity intensity with mortality: A national cohort study of 403 681 US adults,” JAMA Internal Medicine 181, no. 2 (February 2021): 203–211.
Yahyah Aman et al., „Autophagy in healthy aging and disease,” Nature Aging 1, no. 8 (August 2021): 634–650.
Yanfang Wang et al., „Cell–drug conjugates,” Nature Biomedical Engineering (July 2024), https://doi.org/10.1038/s41551-024-01230-6.
Yang Liu et al., „Integration of polygenic and gut metagenomic risk prediction for common diseases,” Nature Aging 4, no. 4 (April 2024): 584–594.
Yang Luo et al., „Smoking’s lasting effect on the immune system,” Nature 626, no. 8000 (February 2024): 724–725.
Yangyang Duan et al., „Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice,” Nature Biomedical Engineering 6, no. 2 (February 2022): 168–180.
Yanni Pu et al., „Gut microbial features and circulating metabolomic signatures of frailty in older adults,” Nature Aging (July 2024), https://doi.org/10.1038/s43587-024-00678-0.
Yanping Li et al., „Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: Prospective cohort study,” British Medical Journal 368 (January 2020): l6669.
Yanxia Ye et al., „SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B,” Nature Aging 3, no. 10 (October 2023): 1269–1287.
Yan Zheng et al., „Association of changes in red meat consumption with total and cause specific mortality among US women and men: Two prospective cohort studies,” British Medical Journal 365 (June 2019): 12110.
Yaqi Li et al., „Healthy lifestyle and the likelihood of becoming a centenarian,” JAMA Network Open 7, no. 6 (2024): e2417931-e31.
Yaqin Tu et al., „The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis,” International Journal of Clinical and Experimental Pathology 5, no. 8 (2012): 726–738.
Yasar Arfat Kasu et al., „Anti-ageing antibodies revive the immune system,” Nature 628, no. 8006 (April 2024): 43–45.
Yasmeen Salameh et al., „DNA methylation biomarkers in aging and age-related diseases,” Frontiers in Genetics 11 (March 2020): 171.
Yee Hui Yeo et al., „Increased risk of aspiration pneumonia associated with endoscopic procedures among patients with glucagon-like peptide 1 receptor agonist use,” Gastroenterology (March 2024), https://doi.org/10.1053/j.gastro.2024.03.015.
Yi-Han Sheu et al., „AI-assisted prediction of differential response to antidepressant classes using electronic health records,” NPJ Digital Medicine 6, no. 1 (April 2023): 73.
Yi Duan et al., „Bacteriophages and their potential for treatment of gastrointestinal diseases,” Nature Reviews Gastroenterology & Hepatology 19, no. 2 (February 2022): 135–144.
Yi Luan et al., „Cardiac cell senescence: Molecular mechanisms, key proteins and therapeutic targets,” Cell Death Discovery 10, no. 1 (February 2024): 78.
Ying Sun et al., „Sweetened beverages, genetic susceptibility, and incident atrial fibrillation: A prospective cohort study,” Circulation: Arrhythmia and Electrophysiology 17, no. 3 (March 2024): e012145.
Yiqiu Shen et al., „Artificial intelligence system reduces false-positive findings in the interpretation of breast ultrasound exams,” Nature Communications 12, no. 1 (September 2021): 5645.
Yiwei Lai et al., „Multimodal cell atlas of the ageing human skeletal muscle,” Nature 629, no. 8010 (May 2024): 154–164.
Yi Zhu et al., „The Achilles’ heel of senescent cells: From transcriptome to senolytic drugs,” Aging Cell 14, no. 4 (August 2015): 644–658.
Yoav Ben-Shlomo et al., „The epidemiology of Parkinson’s disease,” Lancet 403, no. 10423 (January 2024): 283–292.
Yolanda Diz-Chaves et al., „Anti-inflammatory effects of GLP-1 receptor activation in the brain in neurodegenerative diseases,” International Journal of Molecular Sciences 23, no. 17 (August 2022): 9583.
Yong-Joon Lee et al., „Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: Secondary analysis of the randomised lodestar trial,” BMJ 383 (2023): e075837.
YongRong Lei et al., „Investigating the crosstalk between chronic stress and immune cells: Implications for enhanced cancer therapy,” Frontiers in Neuroscience 17 (November 2023): 1321176.
Yoshiaki Oda et al., „Immunogenicity and safety of a booster dose of a self-amplifying RNA Covid-19 vaccine (arct-154) versus BNT162b2 mRNA covid-19 vaccine: A double-blind, multicentre, randomised, controlled, Phase 3, non-inferiority trial,” Lancet Infectious Diseases 24, no. 4 (April 2024): 351–360.
Young-Joon Surh, „The 50-year war on cancer revisited: Should we continue to fight the enemy within?,” Journal of Cancer Prevention 26, no. 4 (December 2021): 219–223.
Yu-Qin Mao et al., „The antitumour effects of caloric restriction are mediated by the gut microbiome,” Nature Metabolism 5, no. 1 (January 2023): 96–110.
Yuancheng Lu et al., „Reprogramming to recover youthful epigenetic information and restore vision,” Nature 588, no. 7836 (December 2020): 124–129.
Yuan Ma et al., „24-hour urinary sodium and potassium excretion and cardiovascular risk,” New England Journal of Medicine 386, no. 3 (January 2022): 252–263.
Yudiyang Ma et al., „Air pollution, genetic susceptibility, and the risk of atrial fibrillation: A large prospective cohort study,” Proceedings of the National Academy of Sciences 120, no. 32 (2023): e2302708120.
Yue Leng et al., „To nap or not to nap: More questions than answers,” Heart 105, no. 23 (December 2019): 1768–1769.
Yu Guo et al., „Plasma proteomic profiles predict future dementia in healthy adults,” Nature Aging 4, no. 2 (February 2024): 247–260.
Yuhua Zhou et al., „Comparison of pathogen detection consistency between metagenomic next-generation sequencing and blood culture in patients with suspected blood-stream infection,” Scientific Reports 13, no. 1 (June 2023): 9460.
Yujie Zhao et al., „Association of healthy lifestyle with the incidence of the risk of developing a broad range of diseases: A prospective cohort study,” Lancet, March 15, 2024, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4754924.
Yukiteru Nakayama et al., „Heart failure promotes multimorbidity through innate immune memory,” Science Immunology 9, no. 95 (May 2024): eade3814.
Yukun Zhou et al., „A foundation model for generalizable disease detection from retinal images,” Nature 622, no. 7981 (October 2023): 156–163.
Yunhe Wang et al., „Long-term risk of psychiatric disorder and psychotropic prescription after SARS-CoV-2 infection among UK general population,” Nature Human Behaviour 8 (March 2024), https://doi.org/10.1038/s41562-024-01853-4.
Yunjae Kim et al., „Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor,” Cell Host Microbe (July 2024), https://doi.org/10.1016/j.chom.2024.06.010.
Yun Min Song et al., „Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: Insights from longitudinal wearable device data,” EBioMedicine 103 (April 2024): 105094.
Yuting Xie et al., „Credibility of the evidence on green space and human health: An overview of meta-analyses using evidence grading approaches,” EBioMedicine 106 (August 2024): 105261.
Yuxiang Ma et al., „BL-B01D1, a first-in-class EGFR-her3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: A first-in-human, open-label, multicentre, Phase 1 study,” Lancet Oncology 25, no. 7 (July 2024): 901–911,
Yuzhe Yang et al., „Artificial intelligence-enabled detection and assessment of Parkinson’s disease using nocturnal breathing signals,” Nature Medicine 28, no. 10 (October 2022): 2207–2215.
Yuzhu Li et al., „The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health,” Nature Aging 2, no. 5 (May 2022): 425–437.
Zaira Seferbekova et al., „Spatial biology of cancer evolution,” Nature Reviews Genetics 24, no. 5 (May 2023): 295–313.
Zaoqu Liu et al., „Immunosenescence: Molecular mechanisms and diseases,” Signal Transduction and Targeted Therapy 8, no. 1 (May 2023): 200.
Zehua Yan et al., „Analysis of microplastics in human feces reveals a correlation between fecal microplastics and inflammatory bowel disease status,” Environmental Science & Technology 56, no. 1 (January 2022): 414–421.
Zeljko Pedisic et al., „Is running associated with a lower risk of all-cause, car-diovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis,” British Journal of Sports Medicine 54, no. 15 (August 2020): 898–905.
Zhao Sun et al., „Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming,” Science 385, no. 6708 (2024): adl2992.
Zhe Fang et al., „Association of ultra-processed food consumption with all cause and cause specific mortality: Population based cohort study,” British Medical Journal 385 (May 2024): e078476.
Zhenfei Xie et al., „mRNA-lnp HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies,” Science 384, no. 6697 (2024): eadk0582.
Zhenwei Yu et al., „Molecular beacon-based detection of circulating microrna containing extracellular vesicle as an α-synucleinopathy biomarker,” Science Advances 10, no. 20 (May 2024): eadl6442.
Zhen Yang et al., „Correlation of an epigenetic mitotic clock with cancer risk,” Genome Biology 17, no. 1 (October 2016): 205.
Zhilei Shan et al., „Association between healthy eating patterns and risk of cardiovascular disease,” JAMA Internal Medicine 180, no. 8 (August 2020): 1090–100.
Zhilei Shan et al., „Healthy eating patterns and risk of total and cause-specific mortality,” JAMA Internal Medicine 183, no. 2 (February 2023): 142–153.
Zhonghao Yu et al., „Human serum metabolic profiles are age dependent,” Aging Cell 11, no. 6 (December 2012): 960–967.
Zibin Tan et al., „A comprehensive synthetic library of poly-n-acetyl glucosamines enabled vaccine against lethal challenges of staphylococcus aureus,” Nature Communi-cations 15, no. 1 (April 2024): 3420.
Zijia Liu et al., „Early predictor for the onset of critical transitions in networked dynamical systems,” Physical Review X 14, no. 3 (July 2024): 031009.
Zilong Bian et al., „Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: Evidence from multiple cohort studies,” BMJ Evidence-Based Medicine (April 2024): bmjebm-2023-112583.
Zizhen Yao et al., „A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain,” Nature 624, no. 7991 (December 2023): 317–332.
Zonghua Li et al., „A water pill against Alzheimer’s disease,” Nature Aging 1, no. 10 (October 2021): 868–869.
Zornitza Stark et al., „Genomic newborn screening for rare diseases,” Nature Reviews Genetics 24, no. 11 (November 2023): 755–766.
“90 percent of heart disease is preventable through healthier diet, regular exercise, and not smoking,” Cleveland Clinic Newsroom, September 29, 2021, https:// newsroom.clevelandclinic.org/2021/09/29/90-percent-of-heart-disease-is-preventable-through-healthier-diet-regular-exercise-and-not-smoking.
“A big week for GLP-1 drugs,” Substack, April 6, 2024, https://erictopol.substack.com/p/a-big-week-for-glp-1-drugs.
“ACR statement on screening total body MRI,” American College of Radiology, April 17, 2023, https://www.acr.org/Media-Center/ACR-News-Releases/2023/ACR-Statement-on-Screening-Total-Body-MRI.
“A dog’s life could hold the key to anti-aging drugs for humans,” Wired, June 28, 2024, https://www.wired.com/story/have-a-nice-future-podcast-12/.
“AI can predict tipping points before they happen,” Economist, July 17, 2024, https://www.economist.com/science-and-technology/2024/07/17/ai-can-predict-tipping-points-before-they-happen.
“Animals with the longest lifespans,” International Fund for Animal Wel-fare, April 4, 2024, https://www.ifaw.org/journal/animals-longest-lifespans.
“Antimicrobial resistance: An agenda for all,” Lancet 403, no. 10442 (June 2024): 2349.
“A research study investigating semaglutide in people with early Alzheimer’s disease (evoke+),” US National Library of Medicine, April 30, 2024, https://classic.clinicaltrials.gov/ct2/show/NCT04777409.
“Are you interested in enrolling your dog in triad?,” Dog Aging Project, accessed June 26, 2024, https://dogagingproject.org/triad.
“ASCO: New ‘armored’ CAR produces significant responses in patients whose cancers don’t respond to current CAR T cell therapies,” Penn Medicine News, June 1, 2024, https://www.pennmedicine.org/news/news-releases/2024/june/asco-new-armored-car-produces-significant-responses#:~:text=According%20to%20the%20results%20of,or%20had%20 stopped%20responding%20to.
“A study of an Epstein-Barr virus (EBV) candidate vaccine, mRNA-1189, in 12- to 30-year-old healthy adolescents and adults,” National Library of Medicine, NIH, accessed May 8, 2023, https://clinicaltrials.gov/study/NCT05164094.
“Autoimmune facts,” American Autoimmune Related Diseases Association, December 12, 2019, https://autoimmune.org/wp-content/uploads/2019/12/1-in-5-Brochure.pdf.
“Biobank and biorepository created from healthy longevity clinic,” Mayo Clinic, accessed June 26, 2024, https://www.mayo.edu/research/clinical-trials/cls-20541259.
“Brain-boosting substances are all the rage,” Economist, March 7, 2024, https://www.economist.com/business/2024/03/07/brain-boosting-substances-are-all-the-rage.
“Breast cancer risk assessment tool: Online calculator (the Gail Model),” National Cancer Institute, NIH, accessed July 1, 2024, https://bcrisktool.cancer.gov.
“Cancer data and statistics,” CDC, June 11, 2024, https://www.cdc.gov/cancer/data/?CDC_AAref_Val=https://www.cdc.gov/cancer/dcpc/data/index.htm#.
“Cellular senescence network,” SenNet Consortium, accessed June 26, 2024, https://sennetconsortium.org.
“Center for innovative phage applications and therapeutics,” UCSD School of Medicine, accessed July 1, 2024, https://sites.medschool.ucsd.edu/som/medicine/divisions/idgph/research/center-innovative-phage-applications-and-therapeutics/pages/default.aspx.
“Clinical study protocol,” Young Blood Institute, accessed June 26, 2024, https://youngbloodinstitute.org/about.html.
“Clues to a possible cure for aids,” Economist, July 22, 2024.
“Colorectal cancer cases more than tripled among teens over two decades,” Digestive Disease Week, May 10, 2024, https://ddw.org/colorectal-cancer-cases-more-than-tripled-among-teens-over-two-decades/#:~:text=Between%201999%20and%202020%2C%20 the,20%20to%2024%2C%20researchers%20said.
“Compare the nutrition quality of food products with the Nutri-Score!” Open Food Facts, 2024, https://world.openfoodfacts.org/nutriscore.
“Compare TruAge tests,” TruDiagnostic, accessed June 26, 2024, https://shop.tru diagnostic.com/products/copy-of-biological-age.
“Coronavirus (Covid-19) vaccinations,” Our World in Data, accessed July 1, 2024, https://ourworldindata.org/covid-vaccinations.
“Diabetes statistics,” National Institutes of Health, January 2024, https://www.niddk.nih.gov/health-information/health-statistics/diabetes-statistics.
“Diets & weight loss,” Amazon, 2024, https://www.amazon.com/Diets-Weight-Loss-Books/b?node=4613.
“Digital cognitive behavioral therapy for insomnia: Platforms and characteristics,” American Academy of Sleep Medicine, accessed July 2, 2024, https://aasm.org/digital-cognitive-behavioral-therapy-for-insomnia-platforms-and-characteristics/.
“Disease factsheet about poliomyelitis,” European Centre for Disease Prevention and Control, November 28, 2023, https://www.ecdc.europa.eu/en/poliomyelitis/facts#:~:text=The%20majority%20of%20poliovirus%20infections,than%201%25%20of%20all%20infections.
“Do two APOE4 alleles always mean Alzheimer’s,” ALZFORM, May 10, 2024, https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers.
“Do we expect the body to be a ‘One Hoss Shay’?,” Evolution & Medicine Review, accessed June 26, 2024, https://evmedreview.com/do-we-expect-the-body-to-be-a-one-hoss-shay/.
“Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: An individual participant data meta-analysis,” Lancet Diabetes & Endocrinology 12, no. 5 (May 2024): 306–319.
“Endurance exercise causes a multi-organ full-body molecular reaction,” Nature (May 2024), https://doi.org/10.1038/d41586-024-00585-9.
“Epigenetic leaderboard,” Rejuvenation Olympics, accessed June 26, 2024, https://rejuvenationolympics.com.
“Familial hypercholesterolemia,” Centers for Disease Control and Prevention, 2024, https://www.cdc.gov/genomics/disease/fh/FH.htm#:~:text=One%20of%20the%20 main%20signs,through%20routine%20blood%20cholesterol%20screening.
“FDA approves first orally administered fecal microbiota product for the prevention of recurrence of clostridioides difficile infection,” FDA, April 26, 2023, https://www.fda.gov/news-events/press-announcements/fda-approves-first-orally-administered-fecal-microbiota-product-prevention-recurrence-clostridioides.
“FDA approves use of drug to reduce risk of cardiovascular events in certain adult patient groups,” FDA, December 13, 2019, https://www.fda.gov/news-events/press-announcements/fda-approves-use-drug-reduce-risk-cardiovascular-events-certain-adult-patient-groups.
“First cancer til therapy gets FDA approval for advanced melanoma,” National Cancer Institute, March 2024, https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-amtagvi-til-therapy-melanoma.
“From promise to progress. The future of health research is now,” National Institutes of Health, accessed July 22, 2024, https://allofus.nih.gov.
“Galleri trial,” NHS, accessed July 1, 2024, https://www.nhs-galleri.org/about-the-trial.
“Get the facts on healthy aging,” NCOA, October 20, 2023, https://www.ncoa.org/article/get-the-facts-on-healthy-aging.
“Glossary - Base,” Innovative Genomics Institute, accessed June 26, 2024, https://innovativegenomics.org/glossary/base-espanol/.
“GlycanAge – the best biological age test to discover, measure and optimise,” Glycan-Age, 2024, https://glycanage.com.
“H. Benjamin Larman, Ph.D.,” Johns Hopkins University, accessed June 26, 2024, https://pathology.jhu.edu/autoimmune/about-us/ben-larman.
“Health & education, pesticides,” National Institute of Environmental Health Sciences, accessed July 29, 2024, https://www.niehs.nih.gov/health/topics/agents/pesticides.
“Healthy life expectancy (HALE) data by country,” World Health Organization, 2020, https://apps.who.int/gho/data/view.main.HALEXv.
“Heart disease causes one in five American deaths,” USAFacts, January 4, 2024, https://usafacts.org/articles/how-many-people-have-heart-disease/#:~:text=In%202021%2C%20the%20heart%20disease,in%20the%20US%20since%201950.
“Heart disease facts,” CDC, May 15, 2024, https://www.cdc.gov/heart-disease/data-research/facts-stats/?CDC_AAref_Val=https://www.cdc.gov/heartdisease/facts.htm.
“How much would giving up meat help the environment?,” Economist, November 15, 2019, https://www.economist.com/graphic-detail/2019/11/15/how-much-would-giving-up-meat-help-the-environment.
“Insilico’s AI candidate for IPF doses first patient in Phase II,” Genetic Engineering & Biotechnology News, June 27, 2023, https://www.genengnews.com/topics/artificial-intelligence/insilicos-ai-candidate-for-ipf-doses-first-patient-in-phase-ii/.
“In small trial, gene therapy spurs APOE2 production,” ALZFORM, December 14, 2022, https://www.alzforum.org/news/conference-coverage/small-trial-gene-therapy-spurs-apoe2-production.
“Integrative medicine and health in Minnesota overview,” Mayo Clinic, January 16, 2024, https://www.mayoclinic.org/departments-centers/integrative-medicine-and-health-services-in-minnesota/sections/overview/ovc-20529751.
“Intellia therapeutics and recode therapeutics announce strategic collaboration to develop novel gene editing therapies for cystic fibrosis,” Business Wire, February 15, 2024, https://www.businesswire.com/news/home/20240215392146/en/Intellia-Thoration-to-Develop-Novel-Gene-Editing-Therapies-for-Cystic-Fibrosis.
“Johnson & Johnson, Pfizer, Eli Lilly and other big pharmas are backing this San Diego biotech with $1752M,” San Diego Union Tribune, March 20, 2024, https://www.sandiegouniontribune.com/2024/03/20/johnson-johnson-pfizer-eli-lilly-and-other-big-pharmas-are-backing-this-san-diego-biotech-with-175m/.
“Lecanemab for Alzheimer’s disease: Tempering hype and hope,” Lancet 400, no. 10367 (December 2022): 1899.
“Limitations of mammograms,” American Cancer Society, accessed July 1, 2024, https://www.cancer.org/cancer/types/breast-cancer/screening-tests-and-early-detection/mammograms/limitations-of-mammograms.html#:~:text=About%20half%20of%20the%20women,positive%20finding%20at%20some%20point.
“Live better longer,” Generation Lab, accessed June 26, 2024, https://www.generationlab.com.
“Live your healthiest life possible, for longer,” Elysium, accessed June 26, 2024, https://get.elysiumhealth.com/shop-all/?nbt=nb%3Aadwords%3Ag%3A11596471815%3A116663484841%3A680185599357&nb_adtype=&nb_kwd=elysium%20health&nb_ti=kwd-306207882666&nb_mi=&nb_pc=&nb_pi=&nb_ppi=&nb_placement=&nb_si=%7Bsourceid%7D&nb_li_ms=&nb_lp_ms=&nb_fii=&nb_ap=&nb_mt=e&gad_source=1&gclid=EAIaIQobChMItYuLu7aQhgMVcA2tBh2GSQ83EAAYASAAEgJZB_D_BwE.
“Loneliness and social isolation linked to serious health conditions,” Centers for Disease Control and Prevention, April 29, 2021, https://www.cdc.gov/aging/publications/features/lonely-older-adults.html.
“Menopausal hormone therapy and cancer,” NIH National Cancer Institute, September 25, 2023, https://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/mht-fact-sheet.
“Microplastics are everywhere—we need to understand how they affect human health,” Nature Medicine 30, no. 4 (April 2024): 913.
“MIPSA molecular indexing of proteins by self-assembly,” Infinity Bio, accessed June 26, 2024, https://www.infinitybio.com/mipsa/.
“Mitochondrial gene editing,” Nature Reviews Methods Primers 3, no. 1 (March 2023): 20.
“Multi-cancer detection (MCD) research,” National Cancer Institute, NIH, accessed July 1, 2024, https://prevention.cancer.gov/major-programs/multi-cancer-detection-mcd-research.
“Multiplying the possibilities for patients,” Capstan Therapeutics, accessed May 18, 2024, https://www.capstantx.com.
“Music as medicine: The science and clinical practice,” National Center for Complementary and Integrative Health, NIH, December 14–15, 2023, https://www.nccih.nih.gov/news/events/music-as-medicine-the-science-and-clinical-practice.
“National library of medicine. Study of EBT-101 in aviremic HIV-1 infected adults on stable ART” accessed April 23, 2024, ClinicalTrials.gov, November 7, 2023, https://clinicaltrials.gov/study/NCT05144386.
“New report calls for urgent action to avert antimicrobial resistance crisis,” World Health Organization, April 29, 2019, https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis.
“NOVOS Age,” Novos Labs, accessed June 26, 2024, https://novoslabs.co/product/novos-age/
“Nox health closes acquisition of Somryst, the only FDA-cleared digital insomnia treatment,” Nox Medical, accessed June 26, 2024, https://noxmedical.com/about/news-press/article/nox-health-closes-acquisition-of-somryst-the-only-fda-cleared-digital-insomnia-treatment-from-pear-therapeutics/.
“Nutrient recommendations and databases,” NIH Office of Dietary Supplements, accessed June 26, 2024, https://ods.od.nih.gov/HealthInformation/nutrientrecom mendations.aspx.
“Nutrition for precision health, powered by the All of Us research program,” NIH Office of Strategic Coordination, accessed July 25, 2024, https://commonfund.nih.gov/nutritionforprecisionhealth.
“Obesity-related cardiovascular disease deaths tripled between 1999 and 2020,” American Heart Association, September 6, 2023, https://newsroom.heart.org/news/obesity-related-cardiovascular-disease-deaths-tripled-between-1999-and-2020.
“Operation Warp Speed. Accelerated Covid-19 vaccine development status and efforts to address manufacturing challenges,” US Government Accountability Office, February 2021, https://www.gao.gov/assets/gao-21-319.pdf.
“Operation Warp Speed: Implications for global vaccine security,” Lancet Global Health 9, no. 7 (July 2021): e1017-e21.
“Our mission: Cure autoimmune disease,” Parvus Therapeutics, accessed May 15, 2024, https://parvustx.com.
“Overview: Cancer,” NHS, October 13, 2022, https://www.nhs.uk/conditions/cancer/#:~:text=The%20cancerous%20cells%20can%20invade,of%20cancer%20during%20their%20lifetime.
“Pancreatic cancer risk factors,” American Cancer Society, accessed August 6, 2024, https://www.cancer.org/cancer/types/pancreatic-cancer/causes-risks-prevention/risk-factors.html.
“Pesticides,” Wikipedia, accessed July 29, 2024, https://en.wikipedia.org/wiki/Health_effects_of_pesticides.
“Physics makes aging inevitable, not biology,” Medium, September 6, 2018, https://medium.com/s/nautilus-aging/physics-makes-aging-inevitable-not-biology-b0334308f694.
“Pipeline,” Alkahest, accessed June 26, 2024, https://www.alkahest.com/pipeline/akst-grf6019/.
“Prevention,” World Heart Federation, accessed July 31, 2024, https://world-heart-federation.org/what-we-do/prevention/#:~:text=According%20to%20the%20World%20Health,attacks%20and%20strokes%20are%20preventable.
“Preventive surgery to reduce breast cancer risk,” American Can-cer Society, accessed July 1, 2024, https://www.cancer.org/cancer/types/breast-cancer/risk-and-prevention/preventive-surgery-to-reduce-breast-cancer-risk.html#:~:text=Most%20women%20with%20a%20BRCA1,might%20not%20have%20been%20helpful.
“ProteinMPNN excels at creating new protein,” Baker Lab, September 16, 2022, https://www.bakerlab.org/2022/09/16/proteinmpnn-excels-at-creating-new-proteins/.
“Randomized trial reveals anti-inflammatory power of aerobic exercise in adults with obesity—helping to mitigate risks of metabolic diseases,” European As-sociation for the Study of Obesity, May 12, 2024, https://www.eurekalert.org/news-releases/1044182#:~:text=New%20research%20being%20presented%20at,to%20help%20prevent%20multiple%20metabolic.
“RCIGM launches program to advance newborn screening for treatable genetic diseases,” Rady Children’s Institute Genomic Medicine, June 14, 2022, https://radygenomics.org/2022/rcigm-launches-program-to-advance-newborn-screening-for-treatable-genetic-diseases/.
“Safety and immunogenicity of an Epstein-Barr virus (EBV) gp350-ferritin nanoparticle vaccine in healthy adults with or without EBV infection,” National Library of Medicine, NIH, accessed May 8, 2024, https://clinicaltrials.gov/study/NCT04645147#study-overview.
“Science that strikes the right chord,” Cabaletta Bio, accessed July 1, 2024, https:// www.cabalettabio.com.
“Scripps Translational Science award,” Scripps Research, March 1, 2018, https://www.scripps.edu/science-and-medicine/translational-institute/about/translational-science-award/.
“Slow aging at the cellular level and increase energy,” Tally Health, accessed June 26, 2024, https://try.tallyhealth.com/vitality-amplify-only/
“Sonoma Biotherapeutics to present preclinical data from novel Treg therapy for rheumatoid arthritis at American College of Rheumatology convergence 2023,” Sonoma Biotherapeutics, November 6, 2023, https://sonomabio.com/2023/11/sonoma-biotherapeutics-to-present-preclinical-data-from-novel-treg-therapy-for-rheumatoid-arthritis-at-american-college-of-rheumatology-convergence-2023/.
“Statement from FDA commissioner Scott Gottlieb, M.D., and director of FDA’s Center for Biologics Evaluation and Research Peter Marks, M.D., Ph.D., cautioning consumers against receiving young donor plasma infusions that are promoted as unproven treatment for varying conditions,” US Food & Drug Administration, February 19, 2019, https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-and-director-fdas-center-biologics-evaluation-and-0.
“State of obesity 2023: Better policies for a healthier America,” Trust for America’s Health, 2023, https://www.tfah.org/report-details/state-of-obesity-2023/#:~:text=Nationally%2C%2041.9%20percent%20of%20adults,percent%20and%2045.6%20percent%20respectively.
“State of the air: Key findings,” American Lung Association, accessed July 29, 2024, https://www.lung.org/research/sota/key-findings.
“Statistics about diabetes,” American Diabetes Association, November 2, 2023, https://diabetes.org/about-diabetes/statistics/about-diabetes#:~:text=Overall%20numbers,of%20the%20population%2C%20had%20diabetes.&text=Diagnosed%20and%20undiagnosed%3A%20Of%20the,and%208.7%20million%20were%20undiagnosed.
“Studies show links between built environment, accelerated aging, and environmental sensitivity,” US Environmental Protection Agency, April 19, 2021, https://www.epa.gov/sciencematters/studies-show-links-between-built-environment-accelerated-aging-and-environmental.
“Subclinical coronary atherosclerosis and risk for myocardial infarction in a Danish cohort,” Annals of Internal Medicine 176, no. 4 (2023): 433–442.
“Sweet spot: CRISPR therapeutics, ViaCyte dose first patient with cell therapy for type 1 diabetes,” GenEdge, accessed July 1, 2024, https://www.genengnews.com/gen-edge/sweet-spot-crispr-therapeutics-viacyte-dose-first-patient-with-cell-therapy-for-type-1-diabetes/.
“Testing for diabetes,” CDC, May 15, 2024, https://www.cdc.gov/diabetes/diabetes-testing/?CDC_AAref_Val=https://www.cdc.gov/diabetes/basics/getting-tested.html.
“The plastics we breathe,” Washington Post, July 18, 2024, https://www.washingtonpost.com/climate-environment/interactive/2024/microplastics-air-human-body-organs-spread/.
“The potential to transform treatment,” Anokion, accessed August 16, 2024, https:// anokion.com/pipeline/.
“Therapeutic plasma exchange,” Next Health, accessed June 26, 2024, https://www.next-health.com/product/therapeutic-plasma-exchange.
“Three-year Phase 1 follow-up data for mRNA-based individualized immunotherapy candidate show persistence of immune response and delayed tumor recurrence in some patients with resected pancreatic cancer,” BioNTech, April 7, 2024, https://investors.biontech.de/news-releases/news-release-details/three-year-phase-1-follow-data-mrna-based-individualized.
“Top 10 medications used to treat multiple sclerosis,” Definitive Healthcare, February 28, 2024, https://www.definitivehc.com/resources/healthcare-insights/top-medications-multiple-sclerosis.
“Turkish study finds microplastics in brain cells,” TRT World, accessed July 29, 2024, https://www.trtworld.com/science-and-tech/turkish-study-finds-microplastics-in-brain-cells-17849513.
“U.S. National library of medicine. BEACON: A study evaluating the safety and efficacy of beam-101 in patients with severe sickle cell disease (BEACON),” accessed April 23, 2024, ClinicalTrials.gov, https://classic.clinicaltrials.gov/ct2/show/NCT05456880.
“Undiagnosed diseases network (UDN) program snapshot,” Office of Strategic Coordination, NIH, accessed June 26, 2024, https://commonfund.nih.gov/Diseases#:~:text=The%20NIH%20Undiagnosed%20Diseases%20Network,suffer%20from%20a%20rare%20disorder.
“University of Calgary discovery of potential treatment for autoimmune diseases takes step forward,” University of Calgary, May 17, 2019, https://ucalgary.ca/news/university-calgary-discovery-potential-treatment-autoimmune-diseases-takes-step-forward.
“We are on a mission to protect the world from cardiovascular disease,” Verve Therapeutics, accessed June 26, 2024, https://www.vervetx.com.
“Who recommends R21/Matrix-M vaccine for malaria prevention in up-dated advice on immunization,” World Health Organization, 2023, https://www.who.int/news/item/02-10-2023-who-recommends-r21-matrix-m-vaccine-for-malaria-prevention-in-updated-advice-on-immunization.
“Why is colorectal cancer rising rapidly among young adults?,” National Cancer Institute, NIH, November 5, 2020, https://www.cancer.gov/news-events/cancer-currents-blog/2020/colorectal-cancer-rising-younger-adults.
“You are what you eat,” Ginger Software, accessed June 26, 2024, https://www.gingersoftware.com/content/phrases/you-are-what-you-eat.